Longitudinal analysis of blood markers reveals progressive loss of resilience and predicts human lifespan limit

We investigated the dynamic properties of the organism state fluctuations along individual aging trajectories in a large longitudinal database of CBC measurements from a consumer diagnostics laboratory. To simplify the analysis, we used a log-linear mortality estimate from the CBC variables as a single quantitative measure of the aging process, henceforth referred to as dynamic organism state indicator (DOSI). We observed, that the age-dependent population DOSI distribution broadening could be explained by a progressive loss of physiological resilience measured by the DOSI auto-correlation time. Extrapolation of this trend suggested that DOSI recovery time and variance would simultaneously diverge at a critical point of 120 − 150 years of age corresponding to a complete loss of resilience. The observation was immediately confirmed by the independent analysis of correlation properties of intraday physical activity levels fluctuations collected by wearable devices. We conclude that the criticality resulting in the end of life is an intrinsic biological property of an organism that is independent of stress factors and signifies a fundamental or absolute limit of human lifespan.

The General Relativistic Perspective

This paper formulates additional General Relativistic [GR] equations. They do not contradict General Relativity. They examine Dr. Einstein’s equations from a Relativistically distorted Perspective. The equations examine the distorted Escape velocity [vesc]a GR object, determining its Real vesc after the distortions of Relativity slow Bosons||Gravitons. In contrast to the variables in the Classical equations of Relativity, variables are more specific in their own respect and in their relationship to vesc, not simply the Time distortion. The values for the quantities of rate (Time and Velocity) are the quantities for zero vesc ||zero deformation. The slowdown of all Bosons also can be showed to mean an absolute limit to vesc. The form of all atoms is not the permanent thing supposed in current thinking. Slowdown of atomic structure Bosons would mean all elements subject to decay. The energy in Boson Structure particles would mean a increase in in particle velocity. With a light speed limit to vesc, all Elements could eventually escape. Hydrogen would be the most likely, with a transformation of free energy into the Kinetic energy needed for escape.

Enhanced Lidov–Kozai migration and the formation of the transiting giant planet WD 1856+534 b

ABSTRACT We investigate the possible origin of the transiting giant planet WD 1856+534 b, the first strong exoplanet candidate orbiting a white dwarf, through high-eccentricity migration (HEM) driven by the Lidov–Kozai (LK) effect. The host system’s overall architecture is a hierarchical quadruple in the ‘2 + 2’ configuration, owing to the presence of a tertiary companion system of two M-dwarfs. We show that a secular inclination resonance in 2 + 2 systems can significantly broaden the LK window for extreme eccentricity excitation (e ≳ 0.999), allowing the giant planet to migrate for a wide range of initial orbital inclinations. Octupole effects can also contribute to the broadening of this ‘extreme’ LK window. By requiring that perturbations from the companion stars be able to overcome short-range forces and excite the planet’s eccentricity to e ≃ 1, we obtain an absolute limit of $a_{1} \gtrsim 8 \, \mathrm{au}\, (a_{3} / 1500 \, \mathrm{au})^{6/7}$ for the planet’s semimajor axis just before migration (where a3 is the semimajor axis of the ‘outer’ orbit). We suggest that, to achieve a wide LK window through the 2 + 2 resonance, WD 1856 b likely migrated from $30 \, \mathrm{au}\lesssim a_{1} \lesssim 60 \, \mathrm{au}$, corresponding to ∼10–$20 \, \mathrm{au}$ during the host’s main-sequence phase. We discuss possible difficulties of all flavours of HEM affecting the occurrence rate of short-period giant planets around white dwarfs.

Longitudinal analysis of blood markers reveals progressive loss of resilience and predicts ultimate human lifespan limit

We investigated the dynamic properties of the organism state fluctuations along individual aging trajectories in a large longitudinal database of CBC measurements from a consumer diagnostics laboratory. To simplify the analysis, we used a log-linear mortality estimate from the CBC variables as a single quantitative measure of aging process, henceforth referred to as dynamic organism state index (DOSI). We observed, that the age-dependent population DOSI distribution broadening could be explained by a progressive loss of physiological resilience measured by the DOSI auto-correlation time. Extrapolation of this trend suggested that DOSI recovery time and variance would simultaneously diverge at a critical point of 120-150 years of age corresponding to a complete loss of resilience. The observation was immediately confirmed by the independent analysis of correlation properties of intraday physical activity levels fluctuations collected by wearable devices. We conclude that the criticality resulting in the end of life is an intrinsic biological property of an organism that is independent of stress factors and signifies a fundamental or absolute limit of human lifespan.

Parenthyrsos

The chapter re-examines the eighteenth-century sublime, which we tend to think of in superlatives: the greatest, the most high, the absolute limit. It challenges conventional wisdom that the sublime represents a disenchantment with rules, restraints, and decorum, and therefore breaks with the classical middle. The readings construct a counter-narrative by concentrating on descriptions of its production rather than its effects, and considering some fastidious, anxious accounts by Longinus, G. E. Lessing, Adam Smith, and Immanuel Kant about how to successfully achieve the sublime while avoiding the many pitfalls that surround it. The strategic calculation that goes into the rhetorical management of the sublime suggests that it is something other than absolutely individual, unmediated expression, and that it is closely aligned with the shaded complexities of the middle, rather than the stark simplicity of extremes. Moderation emerges, therefore, as a function of rhetorical rather than normative or aesthetic calculation.

A Speech-Musical Modernism: Harry Partch's Lyric Media

Recent work at the intersection of literary history and sound studies has taught us to regard lyric poetry as a sonic medium in its own right, but what sort of medium is it? This article unfolds lyric's intrinsic intermediality by way of the American composer Harry Partch and his brief collaboration with William Butler Yeats. Rekindling Yeats's turn-of-the-century dream of a new art uniting word and music, Partch's experiments setting poetry to microtonal music involved notating the subtle melodies of speech with new scales and instruments–homemade lyres, in fact. Built to compete with the phonograph, these new-old media pressed lyric to its absolute limit as a symbolic medium, clarifying both lyric's intermediality and its sensitivity to technological change. When Partch, who spent several years as an itinerant “hobo” in the 1930s, transplanted his Yeatsian speech-music to the transient shelters of the Depression-era West and began notating migrant voices, this compositional practice heralded unprecedented possibilities for the literary inscription of speech.

Exploring the nontraditional foreign investment in Sino–Latin American relations: The Chilean case

At the end of 2016, China and Chile increased their bilateral ties to a comprehensive strategic partnership increasingly involving the development of traditional and nontraditional foreign investments. The former is measured under the usual parameters of economic cooperation that includes horizontal and vertical investments. However, during the last decades, new forms of cooperation have emerged based on the creation of a HUB that responds to complex strategies in specific contexts, which implies the willingness of nations to establish sophisticated links in which both countries use their competitive resources in search of a common benefit. Although there is no absolute limit between traditional and nontraditional foreign direct investments, since they are not mutually exclusive, the latter have become fundamental elements in the establishment of Chinese multidimensional relations and are part of the new path of cooperation in the Latin America region. In this context, Chile is one of the countries that has hosted the largest number of hub platforms led by China in South America, which include the Southern Optical Fiber Project, the China-Chile Joint Astronomical Data Center, and the China-South America Transpacific cable. This article explores the dynamics of these initiatives through the case study of China–Chile relations.

Is There a Limit to Human Life Expectancy?

The analysis and prediction of life expectancy trends hold an important role in many aspects of our society. On a macro level, governments rely on life expectancy data to make decisions about public welfare programs, health care, retirement age, and pension programs. On an individual level, many people take life expectancy data into account when planning their retirements and making decisions about their future. Currently, two main schools of thought dominate the debate on the trajectory of life expectancy trends. The Olshansky School argues that global human life expectancy is reaching its absolute limit and predicts that a worldwide plateau in life expectancy will soon be reached. The Vaupel School, however, believes that such a plateau is nowhere in sight, and that humans possess no biological barrier that will prevent life expectancy from increasing indefinitely. In this commentary, I build upon the evidence generated by the Vaupel School by introducing socioeconomic factors into the debate and I argue that with consistent improvements to medical technology and general prosperity we will not encounter a biological limit to human life expectancy in our lifetimes.

Longitudinal analysis of blood markers reveals progressive loss of resilience and predicts ultimate human lifespan limit

ABSTRACTWe investigated the dynamic properties of the organism state fluctuations along individual aging trajectories in a large longitudinal database of CBC measurements from a consumer diagnostics laboratory. To simplify the analysis, we used a log-linear mortality estimate from the CBC variables as a single quantitative measure of aging process, henceforth referred to as dynamic organism state index (DOSI). We observed, that the age-dependent population DOSI distribution broadening could be explained by a progressive loss of physiological resilience measured by the DOSI auto-correlation time. Extrapolation of this trend suggested that DOSI recovery time and variance would simultaneously diverge at a critical point of 120 − 150 years of age corresponding to a complete loss of resilience. The observation was immediately confirmed by the independent analysis of correlation properties of intraday physical activity levels fluctuations collected by wearable devices. We conclude that the criticality resulting in the end of life is an intrinsic biological property of an organism that is independent of stress factors and signifies a fundamental or absolute limit of human lifespan.

Comparative Analysis of Verification Parameters of Event-Specific Methods in GMO Maize

The second most dominant genetically modified (GM) crop is maize. Increasing number of GM maize events puts significant pressure on GMO testing laboratories to achieve the level of competence necessary to fulfill legal requirements. In the European Union, Polymerase Chain Reaction (PCR) is the method of choice for identification and quantification of GMOs. We performed verification of validated methods for identification of four GM maize events. Additionaly we aimed to explore the option of designing a method for simultaneous detection of these events in a multiplex PCR reaction. DNA was extracted from certified reference materials (CRM) using validated CTAB extraction protocol. Concentration of DNA was measured using Qubit dsDNA Broad Range Assay. Amplification of taxon specific marker for maize and all event-specific methods was performed according to the JRC Compendium of Reference Methods for GMO Analysis. Absolute limit of detection (LODabs) was determined for taxon specific and four event specific RealTime PCR based methods. DNA extracted from CRMs showed sufficient concentration for downstream analyses and preparation of dilutions for determination of LODabs. Determined LODabs for all tested methods meet acceptance criteria. As expected, the methods performance with respect to the repeatability and precision decline with the decrease in concentration of the target. Event-specific GA21 and NK603 methods show high Ct values at the determined LODabs. However, by adjusting the concentrations of primers and probes sensitivity of these two methods should be improved. Considering that the amplicons for all five methods are quite short (<120 bp) optimization of multiplex reaction conditions for simultaneous amplification should be feasible