Multiple memory formation in glassy landscapes

Cyclically sheared jammed packings form memories of the shear amplitude at which they were trained by falling into periodic orbits where each particle returns to the identical position in subsequent cycles. While simple models that treat clusters of rearranging particles as isolated two-state systems offer insight into this memory formation, they fail to account for the long training times and multiperiod orbits observed in simulated sheared packings. We show that adding interactions between rearranging clusters overcomes these deficiencies. In addition, interactions allow simultaneous encoding of multiple memories, which would not have been possible otherwise. These memories are different in an essential way from those found in other systems, such as multiple transient memories observed in sheared suspensions, and contain information about the strength of the interactions.

Yu.F. Samarin’s Model of the National State: Between Archaic and Modern

Yu. F. Samarin’s works are traditionally viewed through the prism of his affiliation with Slavophilism. His view of the state is opposed to the idea of the complex empire based on unequal interaction of the central power with the elite of national districts. At the same time it was important for Samarin to see the nation not as an ethnocultural community, but as classless community of equal citizens, who were in identical position in the face of the emperor. Samarin’s attitude to religion and nationality had pragmatic character and were understood as means for the creation of the uniform communicative space inside the state. This position for the most part conformed with the framework of the national state basic model, however there still existed one fundamental difference. Samarin considered not an individual, but the rural community that owned the land, to be the basic unit of the national state. As the result the model of national state was viewed as the synthesis of modernistic (classlessness, pragmatism, equality) and archaic (communality) features.

Factors Influencing Recruitment of Non-Accounting Business Professionals into Internal Auditing

ABSTRACT This paper examines factors affecting non-accounting business professionals' willingness to work in internal auditing. In a 2 × 6 experiment with 502 participants from across the country, we find that, in contrast to prior research examining accountants, business professionals have relatively favorable views of internal audit. Although they hold favorable views, participants were still less likely to apply for a position labeled as internal audit than an identical position with an alternate label. Varying the structure of internal audit, including job responsibilities, career path, and sourcing arrangement, did not affect participants' willingness to apply for an internal audit position. We also find that high academically performing participants are less likely to apply to work in internal audit. Finally, based on an additional survey of 46 business students, we find that lower academically performing students would be more interested in internal audit if it paid more, but higher academically performing students would be more interested if internal audit performed more interesting work, was in a preferred company/field, or if they had more understanding of the profession. Data Availability: Contact the authors.

Eisenstasin, new antistasin family inhibitor from the earthworm

A couple of new antistasin family serine protease inhibitors have been isolated from the non-hematophagous earthworm, Eisenia andrei. These novel inhibitors have been designated as eisenstasin I and II. Similar to other antistasin family inhibitors, eisenstasin I and II feature 3 and 4 internal repeats, respectively, of a 24–29 amino acid sequence, both of which exhibit a conserved pattern of 6-cysteine/2-glycine at an identical position between the third and fourth cysteine residues. This suggests that the eisenstasins isolated from the earthworm are members of the antistasin family. The eisenstasins are 82% similar with regard to amino acid sequences and exhibit over 70% similarity with the antistasins from the earthworm Lumbricus rubellus, while also displaying less than 40% sequence similarity with the leech antistasins. Earthworm eisenstasins are basic proteins, primarily due to the frequent occurrence of arginine residues in their structure, especially at the C-terminal region. As arginine is a key residue for the substrate specificity of some serine proteases including FXa, it is thought that these multiple arginine residues may play a role in the inhibitory characteristics of the eisenstasins. Considering the structure and number of the internal repeats derived from a variety of animal species, the deletion as well as the duplication of all or part of an internal repeat may be implicated in the evolution of the structure and function of the antistasin family inhibitors.

Does PET/CT render software registration obsolete?

Summary:It was the success of software-based image registration that eventually led to the introduction of hardware-based concepts for image fusion, such as combined PET/CT tomographs. A prototype PET/CT was first presented in 1998, with various commercial designs to follow since 2000. PET/ CT is used primarily as a diagnostic modality in the field of extra-cerebral oncology imaging. The major advantage of combined imaging over retrospective software registration is the nearly identical position of the patient during both complementary examination, and therefore tomograms of identical parts of the body can be provided in spatially-corresponding slices. Despite the availability of hardware combinations of complementary imaging modalities software-based image registration, however, still inherits a major role in subsequent data processing, in particular when individual imaging modalities other than combined PET/CT are being used during patient workup. Furthermore, software is likely to become an important tool for the correction of residual motion-induced mis-registration within combined PET/CT data sets, and for follow-up studies involving, for example, CT, PET, and PET/CT. Therefore, flexible algorithms that utilize nonlinear interpolation schemes implemented on fast computer systems are needed, and will continue to contribute to successful image registration and fusion in clinical practice.

Understanding the Cortical Specialization for Horizontal Disparity

Because the eyes are displaced horizontally, binocular vision is inherently anisotropic. Recent experimental work has uncovered evidence of this anisotropy in primary visual cortex (V1): neurons respond over a wider range of horizontal than vertical disparity, regardless of their orientation tuning. This probably reflects the horizontally elongated distribution of two-dimensional disparity experienced by the visual system, but it conflicts with all existing models of disparity selectivity, in which the relative response range to vertical and horizontal disparities is determined by the preferred orientation. Potentially, this discrepancy could require us to abandon the widely held view that processing in V1 neurons is initially linear. Here, we show that these new experimental data can be reconciled with an initial linear stage; we present two physiologically plausible ways of extending existing models to achieve this. First, we allow neurons to receive input from multiple binocular subunits with different position disparities (previous models have assumed all subunits have identical position and phase disparity). Then we incorporate a form of divisive normalization, which has successfully explained many response properties of V1 neurons but has not previously been incorporated into a model of disparity selectivity. We show that either of these mechanisms decouples disparity tuning from orientation tuning and discuss how the models could be tested experimentally. This represents the first explanation of how the cortical specialization for horizontal disparity may be achieved.

Tetracycline Resistance in Chlamydia suis Mediated by Genomic Islands Inserted into the Chlamydial inv-Like Gene

ABSTRACT Many strains of Chlamydia suis, a pathogen of pigs, express a stable tetracycline resistance phenotype. We demonstrate that this resistance pattern is associated with a resistance gene, tet(C), in the chlamydial chromosome. Four related genomic islands were identified in seven tetracycline-resistant C. suis strains. All resistant isolates carry the structural gene tet(C) and the tetracycline repressor gene tetR(C). The islands share significant nucleotide sequence identity with resistance plasmids carried by a variety of different bacterial species. Three of the four tet(C) islands also carry a novel insertion sequence that is homologous to the IS605 family of insertion sequences. In each strain, the resistance gene and associated sequences are recombined into an identical position in a gene homologous to the inv gene of the yersiniae. These genomic islands represent the first examples of horizontally acquired DNA integrated into a natural isolate of chlamydiae or within any other obligate intracellular bacterium.