AbstractAimThis study aims to predict autoimmunity-related pathological mechanisms that posses risk for individuals with certain HLA serotypes and are common to the pathogenicity of certain coronaviruses including SARS-CoV-2, based on homology to a SARS-CoV-2 peptide.MethodsCoronavirus-associated sequences, which are homologous to the SARS-CoV-2 peptide CFLGYFCTCYFGLFC, are obtained. Human peptides that have at least 7 residue matches with those coronavirus sequences, and the SARS-CoV-2 peptide, are obtained. Then, epitope pairs, which are sourced by those coronavirus and human sequences’ alignments, are identified. There, epitope pairs that are predicted to bind strongly not only to the same HLA allele with each other but also to the same HLA allele with the respective alignment of the SARS-CoV-2 peptide are selected.ResultsFollowing is the list of proteins (or regions) with predicted HLA-A*02:01 or HLA-A*24:02 epitopes, which are not only common but also homologous to the epitopes that are sourced by the SARS-CoV-2 peptide and its homologous coronavirus peptides: Immunoglobulin heavy chain junction regions, CRB1 isoform I precursor, slit homolog 2 protein, hCG1995581, hCG2028737, phospholipid phosphatase-related protein type 2. Among those, CRB1 isoform I precursor sequence with the predicted HLA-A*24:02 epitope aligns with the highest number of different coronavirus sequences.ConclusionResults imply autoimmunity risk in COVID-19 patients with HLA-A*02:01 and HLA-A*24:02 serotypes, through molecular mimicry, as a common pathogenicity risk that can be prevalent upon getting infected with certain other coronaviruses. These results can pave the way to improved risk groups’ assessment and autoimmunity treatment options, to be used in COVID-19 and its associated diseases.