Estudo do padrão de melhora da alopecia androgenética em pacientes com uso de microagulhamento associado a minoxidil e/ou plasma rico em plaquetas e mesoterapia / Study of the pattern of improvement in androgenetic alopecia in patients using microneedling associated with minoxidil and/or platelet-rich plasma and mesotherapy

Introdução: a alopécia ligada a fatores hormonais androgênicos é algo que há muito tempo tem sido alvo de estudos e aplicações de conhecimento científico em todo mundo. Este padrão de perda capilar, principalmente ligada ao sexo masculino dispõe de terapias que atualmente se limitam à interrupção da queda de fios com leve progressão de crescimento em alguns casos. Neste tocante, uma nova técnica de microagulhamento, com ou sem terapias adjuvantes, associado a métodos já consagradas como minoxidil tem levado o tratamento desta alteração estética para melhores níveis de resultado. Objetivo: conduzir uma investigação sobre os resultados atuais de pesquisas que envolvam o microagulhamento associado ao uso de Minoxidil, plasma rico em plaquetas e/ou mesoterapia. Metodologia: foram feitas pesquisas no banco de dados da PubMed e Scielo em abril de 2021 buscando-se os termos “minoxidil AND microneedling”. Resultados e Discussões: os resultados obtidos têm convergido para a proposta de que a associação do método de rolagem (microagulhamento) com a aplicação tópica do vasodilatador (minoxidil) apresenta um padrão de crescimento capilar nunca alcançado pela terapia convencional disponível, e que, se acrescentar plasma rico em plaquetas e/ou soluções através da mesoterapia, os resultados podem ser ainda mais vantajosos. Conclusão: novos estudos são necessários para abranger as vertentes ainda não elucidadas para o tratamento da alopecia, contudo, os resultados até aqui obtidos são promissores para o sucesso da reposição capilar.Palavras chave: Microagulhamento, Minoxidil, Alopecia AbstractIntroduction: alopecia linked to androgenic hormonal factors is something that has long been the subject of studies and knowledge applications worldwide. This pattern of hairloss, mainly related to males, has therapies that are currently limited to interruption of hair loss with slight growth progression in some cases. In this regard, a new microneedlingtechnique, with or without adjuvant therapies, associated with well-established methods such as minoxidil has led the treatment of this esthetic alteration to better levels of results. Objective: to conduct an investigation into the current results of research involving microneedling associated with the use of Minoxidil, platelet-rich plasma and/or mesotherapy. Methodology: searches were conducted in the PubMed and Scielo database in April 2021, searching for the terms “minoxidil AND microneedling”. Results and Discussions: the results obtained have converged to the proposal that the association of the rolling method(microneedling) with the topical application of a vasodilator (minoxidil) presents a pattern of hair growth never achieved by the available conventional therapy, and that, if addedplatelet-rich plasma and/or solutions through mesotherapy, the results can be even more advantageous. Conclusion: further studies are needed to cover aspects that have notyet been elucidated for the treatment of alopecia, however, the results obtained so far are promising for the success of hair replacement.Keywords: Microneedling, Minoxidil, Alopecia

Preparation and Application of CQDs/Ni(OH)20.75H2O as Electrodes in Supercapacitors

In this paper, a hydrothermal synthesis method for preparation Carbon Quantum Dots (CQDs)/Ni(OH)20.75H2O composite electrode material, and loaded on Nickel Foam(NF) by rolling method. The crystal phase, structure, morphology and the reaction process were characterized by X-ray diffractometer (XRD) and scanning electron microscopy (SEM). The electrochemical properties of the composite were measured by cyclic voltammetry impedance spectroscopy and couple method charge-discharge techniques. The results showed that the composites material was evenly adhered to nickel foam. When the current density is 1 A g−1, the specific capacity of CQDs/Ni (OH) 20.75H2O composite can reach 2115.4 Fg−1, which is close to 5 times of Ni (OH) 20.75 H2O electrode material.

Improving the X-ray Shielding Performance of Tungsten Thin-Film Plates Manufactured Using the Rolling Technology

X-ray shields used for medical purposes are manufactured using lead, which is inexpensive and easy to manufacture. However, as lead can be a major factor contributing toward environmental contamination, such as lead poisoning, a radiation-shielding plate was manufactured in this study using a tungsten plate, an eco-friendly material, through a rolling process at different temperatures. In addition, the shielding plate produced via the hot-rolling method exhibited better shielding performance than that of the plate produced using the cold-rolling method, and the multilayer structure was well formed, as indicated in the cross-sectional image analysis. Upon applying a peak voltage of 100 kVp to the X-ray tube, the shielding performance observed was 80% and 96% when the plate thickness was 0.1 mm and 0.3 mm, respectively. Therefore, it is expected that, in the future, the pure tungsten-based shield presented in this study will replace lead plates, owing to its superior standardization and reproducibility of the shielding performance.

Development of Advanced Technologies for the Production of Innovative Materials with a Submicrocrystalline Structure by Methods of Severe Plastic Deformation

A promising direction for the development of steel and alloy processing processes is the intensification of plastic deformation by creating zones of localization of shear strains not only in the longitudinal but also in the transverse directions of the deformed metal flow. Intensification of alternating deformations along the entire cross-section and, especially, in the axial zone of the billet by creating new deformation schemes is an effective way to increase the physical, mechanical and functional properties of the metal with the maximum approximation of the finished product size to the original billet size. The paper shows that a promising idea is the development of new technological schemes that implement severe alternating deformation in existing metal forming processes. A continuous rolling method of wide strips is proposed, which provides severe alternating deformation with minor changes in the size of the billet. Based on this method, a scheme of continuous rolling of the strip with the intensification of plastic deformation of the metal is designed. The results of computer simulation showed that the new rolling method increases the strain uniformity in height and the value of the strain degree in the plane of symmetry of the billet.

Manufacturing of Wear Resistant Iron-Steel: A Theoretical and Experimental Research on Wear Behavior

In this study, four different alloys of steel blocks with a thickness of 15mm were manufactured in order to develop an alternative to steel plates used in wear exposed areas of construction machines, trucks, and asphalt production plants. To further increase the wear resistance of the manufactured steel blocks, their thickness was reduced to 10mm by the hot-rolling method. Wear specimens were obtained from rolled blocks. These specimens were abraded at 20N, 40N, and 60N loads in reciprocating linear motion module ASTM G-33 standards to determine their wear resistance. SEM and EDX analyses were also conducted to see modifications on the worn surfaces. In addition, a theoretical model of wear behaviors was created, calculations were made with Archard wear equation and ANSYS software, and the theoretical and experimental results were compared

Process Analysis and Roller Optimization of Micro-Groove Multi-Pass Rolling

Micro-grooves with special structure can reduce the surface friction resistance. Rolling method can be used to form micro-grooves on metal surface efficiently. However, the micro grooves formed by this plastic forming method still had some defects, which had a serious negative impact on the drag reduction and mechanical properties of the micro grooves. Therefore, it is of great significance to optimize the multi pass rolling process to avoid the micro-groove defects. In this paper, a series of analysis on the microstructure, strain and material displacement of micro-grooves were carried out to explain the causes of micro groove defects. It was found that the overall extension of the plate has an adverse effect on the formation of micro-grooves and the hole types of the roller were optimized accordingly. The results of simulation and experiment showed that the optimized roller could produce the designed micro-groove, which perfectly avoided the generation of micro defects.