Molecular Evolution of Severe Acute Respiratory Syndrome Coronavirus 2: Hazardous and More Hazardous Strains Behind the Coronavirus Disease 2019 Pandemic and Their Targeting by Drugs and Vaccines

Within almost the last 2 years, the world has been shaken by the coronavirus disease 2019 (COVID-19) pandemic, which has affected the lives of all people. With nearly 4.92 million deaths by October 19, 2021, and serious health damages in millions of people, COVID-19 has been the most serious global challenge after the Second World War. Besides lost lives and long-term health problems, devastating impact on economics, education, and culture will probably leave a lasting impression on the future. Therefore, the actual extent of losses will become obvious only after years. Moreover, despite the availability of different vaccines and vaccination programs, it is still impossible to forecast what the next steps of the virus are or how near we are to the end of the pandemic. In this article, the route of molecular evolution of the coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is thoroughly compiled, highlighting the changes that the virus has undergone during the last 2 years and discussing the approaches that the medical community has undertaken in the fight against virus-induced damages.

Accounting Quality and its Challenges in 21st Century

This paper describes current research to drive future research challenges in accounting quality. The definition of accounting quality is mainly varying depending on the objective that the study pointed. Previous research revealed that many proxies describe the accounting quality but most of them from the financial perspective. Furthermore, this paper tries to expose this research issue in the behavioural approach and drive future research in the mixed method. It concludes that the behavioural issues can be a research model, triggering future research challenges in accounting quality. The authors support these triggers from the perspectives of political hegemony, bureaucracy ratcheting, cognitive distortion, and international accounting standard. Finally, we infer and simultaneously predict that accounting quality would broaden its concepts and lasting impression in the 21st century.

The cognitive poetics of English-Chinese advertisement translation

Advertisements often use poetic methods to increase aesthetic value, evoke emotion, and strengthen recipients’ impression. This study explores the cognitive poetics of English-Chinese advertisement translation and investigates how poetic methods are treated in translation. It draws upon poetics, psychology, and translation to study a corpus of 198 English-Chinese poetic advertisements. Two major poetic methods in the advertising discourse – repetition and image establishment – will be outlined, as well as their functions in invoking an emotional response and lasting impression. Then, analysis of a representative example will demonstrate how the poetic elements are transferred across languages, and the results of two surveys confirm their effects. The discussion is intended to shed light on the audience’s reception and perception of advertisements and provide translators with practical reference regarding poetic methods and the importance of the audience’s emotion and impression.

Can Precision Electrophile Signaling Make a Meaningful and Lasting Impression in Drug Design?

For several years, drugs bearing reactive electrophilic appendages have been developed. These units typically confer prolonged residence time of the drugs on their protein targets, and may assist targeting shallow binding sites and/or improving drug-protein target spectrum. Studies on natural electrophilic molecules have indicated that in many instances natural electrophiles use similar mechanisms to alter signaling pathways. However, natural reactive species are also endowed with other important mechanisms to hone signaling properties that are uncommon in drug design. These include ability to be active at low occupancy and elevated inhibitor kinetics. Here we discuss how we have begun to harness these properties in inhibitor design.

Lasting impression

Picture books are a mainstay of every setting and also one of the more eco-friendly resources available to us. Hilary White provides a guide to taking children through the steps of choosing and buying books online, and learning to care for what arrives.

BRIAN ELIAS (b. 1948)Once Did I Breathe Another’s Breath (2012)

This chapter highlights British composer Brian Elias’s Once Did I Breathe Another’s Breath (2012), a substantial and highly satisfying cycle. The piano part is quite complex and demanding, requiring a player with very safe hands—this is very much a duo partnership. A carefully chosen selection of five texts from the seventeenth century dwells on the theme of love—the first four poems reflecting its happier side, and the final song rueing the fact that its joys fade with time. The warmest resonances of the baritone voice are used to best effect, and there are several moments of heightened sensitivity where the voice rises to soft, sustained high notes which will need good support. The piano writing is full-textured, often intricate and fast-moving, and it pilots the changing moods of the texts. Ultimately, the exceptionally unified musical language maintains cohesion through the cycle, which should make a powerful and lasting impression.

A study of socio-cultural elements in common proverbs in Khorasan Razavi with emphasis on Kashmar city

One of the manifestations of culture and civilization and even literature of any country is the proverbs, rulings and short and rich words that arise from the greats of science and literature or from the common people and in our vast and ancient language there are thousands of proverbs and words Which has taste, thought and kindness and good interpretation in saying the meaning. The people of a society, when they find their experiences and reserves and those of the past as accepted and certain facts, express them in short sentences, in the form of poetry or prose, so that when they use them, the audience Immerse yourself in deep thought and leave a lasting impression on him. In fact, proverbs are the essence of a nation's collective wisdom that has been polished over time and passed down to us heart to heart. In our country, due to its ancient history, there are many proverbs. Although in different Iranian ethnic groups these proverbs have differences in language and dialect, but many of them are common in terms of meaning or concept. This article tries to examine the socio-cultural elements of the proverbs common in Kashmar city, its roots, dialect and their uses.

Ladislaus Jagiello in Modern Polish Culture

This article deals with Polish representations of Władysław II Jagiełło, Grand Duke of Lithuania, ruler of the Crown of the Polish Kingdom, founder of the Jagiellonian dynasty. Research on representations of the past has become one of the main fields of memory studies in recent years. They allow us to look at historical events and their emblematic protagonists through the prism of their successive emanations. The kaleidoscope of images of the past reflects changes in social awareness and collective memory of a given political community. Jagiełło and the Battle of Grunwald (1410), which is inseparably associated with his reign, offer a model case in point. Among the numerous representations of Jagiełło, those created in the nineteenth century have made a lasting impression. At first, they took the form of literary works and paintings, and only later did they appear in political journalism and historiography. With time, they transmogrified into grass-roots commemorative initiatives, the most spectacular manifestation of which was the jubilee of the 500th anniversary of the Battle of Grunwald, celebrated in Kraków in 1910. The works of Józef Ignacy Kraszewski, Henryk Sienkiewicz and Jan Matejko fulfilled their role and became part of the canon, on which the Polish imagination depended from then on, regardless of the changing political configurations. In this way, Jagiełło became one of the most important figures in the pantheon of rulers, while the distant historical experience of the Polish-Lithuanian Commonwealth was permanently grafted onto and modelled the Polish political imagination. This observation is also confirmed by his twentieth-century portrayals in Polish films and historical series.