Enhanced model protein adsorption of nanoparticulate hydroxyapatite thin films on silk sericin and fibroin surfaces

Hydroxyapatite coated metallic implants favorably combine the required biocompatibility with the mechanical properties. As an alternative to the industrial coating method of plasma spraying with inherently potential deleterious effects, sol-gel methods have attracted much attention. In this study, the effects of intermediate silk fibroin and silk sericin layers on the protein adsorption capacity of hydroxyapatite films formed by a particulate sol-gel method were determined experimentally. The preparation of the layered silk protein/hydroxyapatite structures on glass substrates, and the effects of the underlying silk proteins on the topography of the hydroxyapatite coatings were described. The topography of the hydroxyapatite layer fabricated on the silk sericin was such that the hydroxyapatite particles were oriented forming an oriented crystalline surface. The model protein (bovine serum albumin) adsorption increased to 2.62 µg/cm2 on the latter surface as compared to 1.37 µg/cm2 of hydroxyapatite on glass without an intermediate silk sericin layer.

Electroplating of Pure Aluminum from [HMIm][TFSI]–AlCl3 Room-Temperature Ionic Liquid

Electrodeposition of aluminum and its alloys is of great interest in the aerospace, automobile, microelectronics, energy, recycle, and other industrial sectors, as well as for defense and, potentially, electrochemical printing applications. Here, for the first time, we report room-temperature electroplating of pure aluminum on copper and nickel substrates from an ionic liquid (IL) consisting of 1-Hexyl-3-methylimidazolium (HMIm) cation and bis(trifluoromethylsulfonyl)imide (TFSI) anion, with a high concentration of 8 mol/L AlCl3 aluminum precursor. The aluminum deposits are shown to have a homogeneous and dense nanocrystalline structure. A quasi-reversible reaction is monitored, where the current is affected by both charge transfer and mass transport. The electrocrystallization of Al on Ni is characterized by instantaneous nucleation. The deposited Al layers are dense, homogeneous, and of good surface coverage. They have a nanocrystalline, single-phase Al (FCC) structure, with a dislocation density typical of Al metal. An increase in the applied cathodic potential from −1.3 to −1.5 V vs. Pt resulted in more than one order of magnitude increase in the deposition rate (to ca. 44 μm per hour), as well as in ca. one order of magnitude finer grain size. The deposition rate is in accordance with typical industrial coating systems.

DLC coated spur gears – Part II: coating properties and potential for industrial use

Purpose This paper aims to address the coating and compound analysis of diamond-like carbon (DLC) on steel, to understand the frictional behavior in tribological gear systems presented in paper Part I. Here, the Ti and Zr modified DLC coating architectures are analyzed regarding their chemical, mechanical and thermophysical properties. The results represent a systematic analysis of the thermal insulating effect in tribological contact of DLC coated gears. Design/methodology/approach The approach was to evaluate the effect of the substitution of Zr through Ti at the reference coating ZrCg to TiCg and the effect on thermophysical properties. Furthermore, the influence of different carbon and hydrogen contents on the coating and compound properties was analyzed. Therefore, different discrete Ti or Zr containing DLC coatings were deposited on an industrial coating machine. Thereby the understanding of the microstructure and chemical composition of the reference coatings is increased. Findings Results prove comparable mechanical properties of metal modified DLC independent of differences in chemical compositions. Moreover, the compound adhesion between TiCg/16MnCr5E was improved compared to ZrCg/16MnCr5E. The effect of hydrogen content Ψ and carbon content xc on the thermophysical properties is limited by Ψ = 18 at.% and xc = 90 at.%. Practical implications The findings of the combined papers Part I and II show a high potential for industrial application of DLC on gears. Based on the results DLC coatings and gears can be tailored to each other. Originality/value Systematic analysis of DLC coatings were conducted to evaluate the effect of titanium, carbon and hydrogen on thermophysical properties.

Analisis Penerapan Frame Work IDEAS Menggunakan Parameter PEI Guna Menentukan Rancangan Posisi Kerja Operator di CV. Nipson Industrial Coating

Kinerja dari operator atau pekerja pada dasarnya mempengaruhi tingkat keoptimalan suatu pekerjaan.Seperti kondisi kerja, tempat kerja, dan postur kerja yang menjadi faktor utama untuk melakukan suatu pekerjaan. Kenyamanan dan keselamatan kerja pada dasarnya akan dipengaruhi oleh faktor-faktor tersebut. Tingkat keamanan dan kenyamanan pekerja yang buruk salah satunya akan mengakibatkan musculoskeletal disordes (MSDs) berupa cidera otot urat syaraf, urat daging, tulang, persendian tulang, tulang rawan yang disebabkan oleh aktivitas kerja.Untuk menganalisis postur kerja adalah dengan menggunakan konsep ergonomi, metode yang digunakan dalam analisa ini adalah Framework IDEAS (Identify, Design, Evaluate, Adapt,Sustain) metode ini berisikan langkah-langkah dari awal sampai akhir bagaimana mengidentifikasi masalah antara pekerja dengan lingkungan kerjanya lalu dibuat pemecahan masalahnya. Dalam hal ini digunakan softwareJack 8.2 untuk menganalisis postur kerja yang ada dengan parameter PEI (Posture Evaluation Index). CV. Nipson Industrial Coating memiliki penilaian terhadap kenyamanan dan keselamatan operator dalam bekerja di ruang produksi CV. Nipson Industrial Coating, semua operator yang ada di ruang produksi pasti memiliki potensi bahaya dalam beraktivitas, dimana semakin besar nilai PEI (Posture Evaluation Index) maka akan semakin besar potensi bahayanya.Kata Kunci : Ergonomi, Frame Work IDEAS, PEI

Temperature Measurement on Tool Surfaces by Wear Resistant PVD Sensor Coatings

In manufacturing technology, sensors are important elements for monitoring process parameters and for recording data in the Industrie 4.0. Thin sensors manufactured by means of physical vapor deposition (PVD) offer a way to combine wear and corrosion protection on the one hand and the integration of a temperature sensor function on the other hand. For the analysis of the performance of PVD sensor coatings based on the thermoelectric effect, no standardized methods and procedures are state of the art. In this paper a measuring setup is presented, which allows reference measurements using a calibrated thermocouple and a thermographic camera besides the potential difference measurement of the sensor coating. Two measuring modes, which allow a continuous and a discontinuous measurement, are presented. The measuring methodology was evaluated using the PVD sensor coating Al2O3+Ni+NiCr+Al2O3. This multilayer sensor coating was deposited using an industrial coating unit and was tested with regard to the sensor properties. The deposition technology used for the sensor coating results in an interface without defects between the two sensor layers with a smooth transition. This provides a suitable electrical contact and a promising compound adhesion. The results show a suitable and detailed measurement of temperature and potential differences by means of calibrated measurement methods and the sensor coating. The measured results are reproducible and show a linear relationship between the potential difference and the surface temperature.

Robustness Optimization of an Existing Tablet Coating Process Applying Retrospective Knowledge (rQbD) and Validation

The objective of these studies is to verify and validate the improvement in the inter-tablet coating uniformity for an industrially commercialized coated tablet, without involving changes in the approved registration dossier. Using the CPP (critical process parameters) determined from previous retrospective statistical analysis, the recommended working ranges are identified. Retrospective analysis showed that the design of experiments (DoE) provided an improved process variable configuration. Therefore, it is decided to study two critical parameters: Product temperature and drum speed, with an additional 22 experimental design. The quality results of the samples analyzed show that the aesthetic defects of the batches made with the new working ranges have been reduced. These results have also been corroborated with the 42 industrial batches manufactured with the new ranges. With the optimized parameters, tablets have been coated and the suitability of the model determined. The results demonstrated the overall reliability and effectiveness of the proposed Quality by Design approach and provides a useful tool to help optimize the industrial coating process. This study confirms that it is possible to optimize and validate the manufacturing process of an existing commercial product by means of a DoE with retrospective data. Therefore, no variation in the dossier is required.

IMPLEMENTASI LEAN MANUFACTURING PADA PROSES PRODUKSI UNTUK MENGURANGI WASTE GUNA LEBIH EFEKTIF DAN EFISIEN

CV. Nipson Industrial Coating adalah perusahaan yang hanya bergerak untuk memproduksi coating, dimana perlu terus menerus meningkatkan kinerja perusahaan untuk meningkatkan kualitas dan tepat waktu dalam pengiriman ke pada konsumen. Dengan strategi lean manufacturing perusahaan mampu mengidentifikasi jenis pemborosan (waste) yang terjadi dalam proses produksi sehingga waste yang terjadi bisa dihilangkan. Pemborosan (waste) diidentifikasi dengan seven waste, kemudian dilakukan pemetaan secara detail dengan Value Stream Analysis Tools (VALSAT) dan dianalisa akar penyebab masalah dengan Failure Mode and Effect Analysis (FMEA). Dari hasil penelitian ini, didapatkan pemborosan (waste) pada proses produksi adalah waiting/delay dan defect. Dampak dari penerapan strategi lean manufacturing pada proses produksi menurut process activity mapping, meningkatkan process cycle efficiency menjadi 94.84% dan menurut quality filter mapping adalah melaksanakan standarisasi pada material bahan baku kemudian melakukan pelatihan terhadap pekerja dikhususkan terhadap bidangnya masing-masing. Kata Kunci : Lean Manufacturing, Waste, VSM, VALSAT, FMEA