Gambaran Penggunaan dan Penyimpanan Obat oleh Masyarakat di Kota Banjarmasin Tahun 2020

The COVID-19 pandemic has spread throughout the world, including in Banjarmasin, South Kalimantan. People use some medicines to maintain their health. This study aimed to describe the use of drugs in the community and their use and storage during a pandemic. This research method used an observational research design with a cross-sectional approach, using the convenience sampling technique with the google form application. The community-based survey was conducted on 101 respondents representing the community in Banjarmasin City for the general population group. The study results were 2 types of drugs that were widely used by respondents, namely vitamin drugs (72.3%) and supplements (27.7%). Respondents already know how to use drugs according to how they are used (83.2%), and the survey shows excellent results where (90.1%) of respondents take drugs as recommended by health workers. As many as (64.4%) of respondents knew how to store medicines according to their storage and (90.1%) store them properly. The conclusion is that the use and storage have a big impact on the quality of the drug, which currently the most popular are vitamin and symptomatic drugs.

Ruminative Thinking in Chronic Depression: Concept and Validity of Measures

Despite large amount of empirical evidence in support of rumination as a risk factor of depression onset and chronification, theoretical foundations of ruminative thinking are still being discussed. This includes the issue of so-called constructive, or reflec¬tive, ruminations. Objective: This study gives a theoretical review of different views on rumination, empirically tests the idea of constructive and non-constructive rumi¬native thinking, and tests the validity of the Ruminative Response Scale (RRS, Rus sian version) [38]. Study design: We conducted a factor analysis of adapted RRS, as well as an intercorrelational analysis of this scale, Symptom Checklist-90-Revised (SCL-90-r), and the COPE Inventory; hypotheses were tested in a general population group (n=476) and two clinical groups (patients with depressive disorders, n=53, and patients with different diagnoses with recent suicide attempts, n=41). Results: Our theoretical review examines ruminative thinking as a dysfunctional coping strategy (E. Watkins) from the perspective of the structural-dynamic model of thinking in the course of creative problem-solving (V. Zaretsky, A. Kholmogorova). Rumination is conceptualized as getting stuck «in a loop» at certain levels of organization of cognitive processes, which substitutes motivation focus on actual problem solving. The resulting four-factor structure of RRS has good psychometric properties and strong correla¬tions with different psychopathological symptoms and dysfunctional coping strategies (namely, psychological and behavioral avoidance and venting negative emotions); these correlations are found in all resulting factors but one, which implies that it may have a special status. Conclusion: The Russian version of RRS shows good preliminary psychometric characteristics and is viable for practical purposes. The idea of construc¬tive rumination discussed in literature has not been confirmed empirically. ¬

The role of dry mouth in screening sleep apnea

Purpose of the studyEffective screening questionnaires are essential for early detection of obstructive sleep apnea (OSA). The STOP-Bang questionnaire has high sensitivity but low specificity. Dry mouth is a typical clinical sign of OSA. We hypothesised that adding dry mouth in the STOP-Bang questionnaire would improve its specificity.Study designA survey of the incidence of dry mouth was performed in a general population group and suspected sleep apnea clinical population group. Patients with suspected OSA were assessed by laboratory polysomnography and STOP-Bang questionnaire was performed. Adding the option of dry mouth to the OSA screening questionnaire resulted in a new quesionnaire, where cut-off value, diagnostic efficacy and the predictive parameters (sensitivity, specificity, positive predictive value and negative predictive value) were explored.Results(In the 912 general population group, the incidence of dry mouth in the snoring group (54.0%) was much higher than that in the non-snoring group (30.5%) (p<0.05). In 207 patients with suspected OSA, the incidence of dry mouth in the OSA group was much higher than that in the non-OSA group (p<0.05). The sensitivity and specificity of the STOP-Bang questionnaire were 88.8% and 23.7% for identifying OSA, and 92.2% and 23.1% for identifying moderate and severe OSA, respectively. Adding the option of dry mouth (dry mouth every morning) to the STOP-Bang questionare resulted in a new questionnaire (STOP-Bang-dry-mouth questionnarie) with 9 items. Its sensitivity and specificity were 81.70% and 42.10% for identifying OSA, and 89.10% and 42.30% for identifying moderate and severe OSA, respectively.ConclusionsThe dry mouth symptom correlated with snoring and sleep apnea. The specificity of the STOP-Bang questionnaire can be improved by integrating dry mouth. The diagnostic accuracy of the STOP-Bang-dry mouth questionnaire is yet to be further verified in prospective studies.

Medical Professionals Have Higher Risk for Colorectal Adenoma But Lower Risks for Reflux Esophagitis and Atrophic Gastritis: A Propensity Score-Based Analysis

Background: Previous studies had indicated that medical professionals’ lifestyles were not as healthy as recommended. Whether these lifestyles lead to higher incidences of gastrointestinal diseases is unknown. Objectives: To compare the incidences of gastrointestinal diseases between medical professionals and general populations. Methods: Subjects who underwent endoscopy examination for physical examination in Qilu Hospital from January 2017 to September 2019, were retrospectively reviewed. Propensity score based analysis was used to generate two age- and sex-matched groups, Medical Professional Group and General Population Group. The positive rates of gastrointestinal disorders in two groups, were analyzed by Pearson’s Chi-square test. Subgroup analysis within Medical Professional Group was performed to identify risk factors for medical staffs. Results: 1534 records were enrolled, 791 for gastroscope and 743 for colonoscope. Among upper gastrointestinal diseases, the detection rates of atrophic gastritis and reflux esophagitis showed significant differences, which were 19.8% in Medical Professional Group and 25.9% in General Population Group (p=.04) for atrophic gastritis, 4.0% in Medical Professional Group and 12.6% in General Population Group (p<0.001) for reflux esophagitis. Among the subjects who received colonoscopy, the adenoma detection rate of the Medical Professional Group (17.5%) was statistically distinguished from the General Population Group (11.5%) (p = .02). Conclusion: In a provincial comprehensive hospital in China, medical Professional Group has significantly higher risk for colorectal adenoma, but lower risks for atrophic gastritis and reflux esophagitis.

Risks of solid cancers in elderly persons with osteoarthritis or ankylosing spondylitis

Objectives Patients with osteoarthritis and ankylosing spondylitis have lower cancer-related mortality than the general population. We examined risks of solid cancers at 16 sites in elderly patients with knee or hip osteoarthritis (KHOA) or ankylosing spondylitis. Methods In this population-based retrospective cohort study, we used US Medicare data from 1999 to 2010 to identify cohorts of persons with KHOA or ankylosing spondylitis, and a general population group without either condition, who were followed through 2015. We compared cancer incidence among groups, adjusted for age, sex, race, socioeconomic characteristics, geographic region, smoking and comorbidities. Results We studied 2 701 782 beneficiaries with KHOA, 13 044 beneficiaries with ankylosing spondylitis, and 10 859 304 beneficiaries in the general population group. Beneficiaries with KHOA had lower risks of cancer of the oropharynx, oesophagus, stomach, colon/rectum, hepatobiliary tract, pancreas, larynx, lung, and ovary than the general population. However, beneficiaries with KHOA had higher risks of melanoma, renal cell cancer, and cancer of the bladder, breast, uterus and prostate. Associations were similar in ankylosing spondylitis, with lower risks of cancer of the oesophagus, stomach, and lung, and higher risks of melanoma, renal cell cancer, and cancer of the renal pelvis/ureter, bladder, breast, and prostate. Conclusion Lower risks of highly prevalent cancers, including colorectal and lung cancer, may explain lower cancer-related mortality in patients with KHOA or ankylosing spondylitis. Similarities in cancer risks between KHOA and AS implicate a common risk factor, possibly chronic NSAID use.

Characteristics of Helicobacter pylori antibiotic resistance: data from four different populations

Aims To describe the characteristics of Helicobacter pylori (H. pylori) antibiotic resistance in clinical isolates from four populations. Methods In total, 1463 H. pylori strains were examined for antibiotic resistance. Among these strains, 804 were isolated from treatment-naïve adults, 133 from previously treated adults, 100 from treatment-naïve children and 426 from a population who participated in a health survey (age ≥ 40 years). The minimum inhibitory concentration was determined by the E-test method. Results In the treatment-naïve adult group, the resistance rates for metronidazole, clarithromycin, levofloxacin, amoxicillin, rifampicin and tetracycline were 78.4, 19.0, 23.3, 1.2, 1.7 and 2.3%, respectively. Compared with this group, the previously treated adult group had significantly higher resistance rates for metronidazole (99.2%), clarithromycin (58.3%) and levofloxacin (52.3%). In addition, the treatment-naïve children had a lower metronidazole resistance rate (46.0%) than the treatment-naïve adults. The resistance rate for clarithromycin was low in treatment-naïve patients with ages ranging from 10 to 24 years. For the strains isolated from the general population group, the resistance rates for metronidazole, clarithromycin, levofloxacin, amoxicillin, rifampicin and tetracycline were 78.6, 10.1, 25.1, 0.5, 2.1 and 0.9%, respectively. Compared with the treatment-naïve adult group, the general population group showed significant differences in clarithromycin resistance. Conclusion The resistance rates for metronidazole, clarithromycin and levofloxacin were high, especially in previously treated adults. Compared to those in treatment-naïve younger patients, the resistance rates for clarithromycin were significantly lower in treatment-naïve patients with ages ranging from 10 to 24 years and in the general population.

Quality of life and better than well: a mixed method study of long-term (post five years) recovery and recovery capital

Purpose The purpose of this paper is to compare quality of life scores in a long-term recovery population group (post five years) with a general population group and to explore how any differences might be explained by recovering individuals themselves in a small number of follow up qualitative interviews. Design/methodology/approach A sequential explanatory mixed method design combining quantitative quality of life measure (WHOQOL-BREF, 1996) and six subsequent semi-structured individual interviews. The quality of life measure compared long-term recovery scores (post five years) with the general population group. The subsequent qualitative semi-structured interviews explored what the participants themselves said about their recovery. Findings The quantitative data provide evidence of a significant difference in quality of life (WHOQoL-BREF) in two domains. The long-term recovery group (five or more years into recovery) scored higher in both the environment and psychological domains than the general population group. Of the long-term recovery group, 17 people who still accessed mutual aid scored higher in all four domains than those 23 people who did not. The interviews provide evidence of the this difference as result of growth in psychological elements of recovery, such as developing perspective, improvement in self-esteem, spirituality, as well as contributing as part of wider social involvement. Research limitations/implications This study provides support for the quality of life measure as useful in recovery research. The empirical data support the concept of recovery involving improvements in many areas of life and potentially beyond the norm, termed “better than well” (Best and Lubman, 2012; Valentine, 2011; Hibbert and Best, 2011). Limitations: snowballing method of recruitment, and undertaken by public health practitioner. Some suggestions of women and those who attend mutual aid having higher quality of life but sample too small. Practical implications Use QoL measure more in recovery research. Public health practitioners and policy makers need to work with partners and agencies to ensure that there is much more work, not just treatment focused, addressing the wider social and environmental context to support individuals recovering from alcohol and drugs over the longer term. Originality/value One of small number of studies using with participants who have experienced long-term (post five years) recovery, also use of quality of life measure (WHOQOL-BREF, 1996) with this population.

Obstructive sleep apnoea is more prevalent in men with schizophrenia compared to general population controls: results of a matched cohort study

Objectives: Obstructive sleep apnoea (OSA) may be more common in people with schizophrenia compared to the general population, but the relative prevalence is unknown. Here, we determine the relative prevalence of severe OSA in a cohort of men with schizophrenia compared to representative general population controls, and investigate the contribution of age and body mass index (BMI) to differences in prevalence. Methods: Rates of severe OSA (apnoea–hypopnoea index > 30) were compared between male patients with schizophrenia and controls from a representative general population study of OSA. Results: The prevalence of severe OSA was 25% in the schizophrenia group and 12.3% in the general population group. In subgroups matched by age, the relative risk of severe OSA was 2.9 ( p = 0.05) in the schizophrenia subjects, but when adjusted for age and BMI, the relative risk dropped to 1.7 and became non-significant ( p = 0.17). Conclusions: OSA is prevalent in men with schizophrenia. Obesity may be an important contributing factor to the increased rate of OSA.

Patient out-of-pocket medical expenses over 2 years among Queenslanders with and without a major cancer

Medical out-of-pocket costs paid by patients can be problematic when it adversely affects access to care. Survey research involving patients with out-of-pocket expenses may have selection biases, so accurate estimates are unknown. During 2010–11, 419 participants from the QSkin Sun and Health Study (n=43794) had a confirmed diagnosis of either melanoma, prostate, breast, colorectal or lung cancer. These were matched to a general population group (n=421) and a group of high users of GP services (n=419). Medical fees charged and out-of-pocket medical expenses for Medicare services were analysed. Over 2 years, three-quarters of individuals with cancer paid up-front provider fees of up to A$20551 compared with A$10995 for the high GP user group and A$6394 for the general population group. Out-of-pocket expenses were significantly higher for those with cancer (mean A$3514) compared with the high GP-user group (mean A$1837) and general population group (A$1245). Highest expenses were for therapeutic procedures (mean A$2062). Older individuals, those with poor perceived health or private health insurance had the highest costs. Regardless of private insurance status, patients with one of the main five cancers pay significantly higher out-of-pocket costs for health care compared with those without cancer.

Prävalenz und Charakteristika von Muskelkrämpfen bei Patienten mit Varikosis

Background: It has been suggested that limb circulation may be disturbed in patients with muscle cramps due to leg venous hypertension. The aim of this study was to examine the incidence and characteristics of muscle cramps from venous insufficiency. Patients and methods: The incidence and characteristics of muscle cramps, which were investigated by a questionnaire, were compared between 288 patients with incompetence of the long or short saphenous vein and 550 age-matched individuals from the general population. Results: The patient group showed a significantly higher incidence of muscle cramps in the last year than the general population group, 67% and 53%, respectively (p < 0.001). The incidence of calf cramps was significantly higher in the patient group than in the general population group, 91% and 75%, respectively (p < 0.001). Although most subjects reported symptoms occurring only at night, the incidence was significantly higher in the patient group than in the general population group, 78% and 52%, respectively (p < 0.001). There was no significant difference in the duration or severity of muscle cramps between the groups. The patient group showed a significantly higher incidence of more than 12 episodes per year than the general population group (p < 0.001). Conclusions: Muscle cramps in patients with varicose veins occur more frequently and more often at night and in the calf in comparison with those from the general population.