Get to grips with motivation: slipping and gripping movements are biased by approach-avoidance context

People are better at approaching appetitive cues signalling reward and avoiding aversive cues signalling punishment than vice versa. This action bias has previously been shown in approach-avoidance tasks involving arm movements in response to appetitive or aversive cues. It is not known whether appetitive or aversive stimuli also bias more distal dexterous actions, such as gripping and slipping, in a similar manner. To test this hypothesis, we designed a novel task involving grip force control (gripping and slipping) to probe gripping-related approach and avoidance behaviour. 32 male volunteers, aged 18-40 years, were instructed to either grip (“approach”) or slip (”avoid”) a grip-force device with their right thumb and index finger at the sight of positive or negative images. In one version of this pincer grip task, participants were responding to graspable objects and in another version of the task they were responding to happy or angry faces. Bayesian repeated measures Analysis of variance revealed extreme evidence for an interaction between response type and cue valence (Bayes factor = 296). Participants were faster to respond in affect-congruent conditions (“approach appetitive”, “avoid aversive”) than in affect-incongruent conditions (“approach aversive”, “avoid appetitive”). This bias towards faster response times for affect-congruent conditions was present regardless of whether it was a graspable object or a face signalling valence. Since our results mirror the approach and avoidance effects previously observed for arm movements, we conclude that a tendency favouring affectively congruent cue-response mappings is an inherent feature of motor control and thus also includes precision grip.

Singularities of eight- and nine-particle amplitudes from cluster algebras and tropical geometry

We further exploit the relation between tropical Grassmannians and Gr(4, n) cluster algebras in order to make and refine predictions for the singularities of scattering amplitudes in planar $$ \mathcal{N} $$ N = 4 super Yang-Mills theory at higher multiplicity n ≥ 8. As a mathematical foundation that provides access to square-root symbol letters in principle for any n, we analyse infinite mutation sequences in cluster algebras with general coefficients. First specialising our analysis to the eight-particle amplitude, and comparing it with a recent, closely related approach based on scattering diagrams, we find that the only additional letters the latter provides are the two square roots associated to the four-mass box. In combination with a tropical rule for selecting a finite subset of variables of the infinite Gr(4, 9) cluster algebra, we then apply our results to obtain a collection of 3, 078 rational and 2, 349 square-root letters expected to appear in the nine-particle amplitude. In particular these contain the alphabet found in an explicit 2-loop NMHV symbol calculation at this multiplicity.

SUSTAINABILITY, RESILIENCE AND WELLBEING CONVERGENCES FOR PLACE-BASED APPROACHES

The present article is a conceptual and bibliometric radiography of ‘the new trinity of governance’ (Joseph & McGregor, 2020) that includes sustainability, resilience, and wellbeing from the viewpoint of territorial approaches. First, the paper makes theoretical consideration s of the three concepts by analysing their definition and characteristics. Second, the study proposes a bibliometric analysis of the three well-established concepts, taking into account the papers that include the relations between all three in a single framework. Third, we developed a content analysis considering only the most relevant papers in the proposed study area as we try to highlight the main theoretical and empirical implications of overlapping sustainability, resilience, and wellbeing from the viewpoint of place-based strategies and planning as reflected by current scientific research. The results show the prevalence of four major directions of research which include the three concepts as pillars for the theoretical and empirical approaches: 1) nature-centred assessments, 2) safe and sustainable human activities and critical services, 3) participative governance for planning human settlements, 4) individuals’ and communities’ culture and identities. Finally, the missing link that can transform all these convergent, but still diverse, perspectives is identified as being the capabilities theory of Amartya Sen. To accomplish this role, the classic theory was reinterpreted in a broader sustainability-related approach that takes into consideration the equity and wellbeing of individuals and communities, but also the equilibrium between nature and human development. Conclusively, if managed wisely, the new integrative approach could mark a paradigm shift that might push forward new ways of planning and governing sustainable, safe and liveable territories.

CO-llaborative VI-rtual D-esign: A Collaborative Autoethnography on Conducting Exclusively Online, Data-Led Collaborations in the Creative Industries

This collaborative autoethnographic story of #DataCreativities articulates data traces found within the rapid move online in education and creative sectors in Melbourne, Australia. As a result of the lockdowns imposed to combat the initial spread of COVID-19, this collaboratory began within the anxieties of 2020. #DataCreativities takes a data-related approach to understanding the fast-paced shift to making, learning, teaching, and living in a crisis through research and art. Twelve months on, we figure (out) our own data and practice. We ask: What does CO-llaborative VI-rtual D-esign look like, how can it be established, and how can it be sustained?

Authentic Fear Responses in Virtual Reality: A Mobile EEG Study on Affective, Behavioral and Electrophysiological Correlates of Fear

Fear is an evolutionary adaption to a hazardous environment, linked to numerous complex behavioral responses, e.g., the fight-or-flight response, suiting their respective environment. However, for the sake of experimental control, fear is mainly investigated under rather artificial laboratory conditions. The latter transform these evolutionary adaptions into artificial responses, like keystrokes. The immersive, multidimensional character of virtual reality (VR) enables realistic behavioral responses, overcoming aforementioned limitations. To investigate authentic fear responses from a holistic perspective, participants explored either a negative or a neutral VR cave. To promote real-life behavior, we built a physical replica of the cave, providing haptic sensations. Electrophysiological correlates of fear-related approach and avoidance tendencies, i.e., frontal alpha asymmetries (FAA) were evaluated. To our knowledge, this is the first study to simultaneously capture complex behavior and associated electrophysiological correlates under highly immersive conditions. Participants in the negative condition exhibited a broad spectrum of realistic fear behavior and reported intense negative affect as opposed to participants in the neutral condition. Despite these affective and behavioral differences, the groups could not be distinguished based on the FAAs for the greater part of the cave exploration. Taking the specific behavioral responses into account, the obtained FAAs could not be reconciled with well-known FAA models. Consequently, putting laboratory-based models to the test under realistic conditions shows that they may not unrestrictedly predict realistic behavior. As the VR environment facilitated non-mediated and realistic emotional and behavioral responses, our results demonstrate VR’s high potential to increase the ecological validity of scientific findings (video abstract: https://www.youtube.com/watch?v=qROsPOp87l4&feature=youtu.be).

Dirichlet baths and the not-so-fine-grained Page curve

We present a doubly holographic prescription for computing entanglement entropy on a gravitating brane. It involves a Ryu-Takayanagi surface with a Dirichlet anchoring condition. In braneworld cosmology, a related approach was used previously in arXiv:2007.06551. There, the prescription naturally computed a co-moving entanglement entropy, and was argued to resolve the information paradox for a black hole living in the cosmology. In this paper, we show that the Dirichlet prescription leads to reasonable results, when applied to a recently studied wedge holography set up with a gravitating bath. The nature of the information paradox and its resolution in our Dirichlet problem have a natural understanding in terms of the strength of gravity on the two branes and at the anchoring location. By sliding the anchor to the defect, we demonstrate that the limit where gravity decouples from the anchor is continuous — in other words, as far as island physics is considered, weak gravity on the anchor is identical to no gravity. The weak and (moderately) strong gravity regions on the brane are separated by a “Dirichlet wall”. We find an intricate interplay between various extremal surfaces, with an island coming to the rescue whenever there is an information paradox. This is despite the presence of massless gravitons in the spectrum. The overall physics is consistent with the slogan that gravity becomes “more holographic”, as it gets stronger. Our observations strengthen the case that the conventional Page curve is indeed of significance, when discussing the information paradox in flat space. We work in high enough dimensions so that the graviton is non-trivial, and our results are in line with the previous discussions on gravitating baths in arXiv:2005.02993 and arXiv:2007.06551.

Gut Microbiota Modulation in the Context of Immune-Related Aspects of Lactobacillus spp. and Bifidobacterium spp. in Gastrointestinal Cancers

Accumulating evidence has revealed the critical roles of commensal microbes in cancer progression and recently several investigators have evaluated the therapeutic effectiveness of targeting the microbiota. This gut microbiota-related approach is especially attractive in the treatment of gastrointestinal cancers. Probiotics supplementation is a microbiota-targeted strategy that appears to improve treatment efficacy; Lactobacillus spp. and Bifidobacterium spp. are among the most commonly used probiotic agents. These bacteria seem to exert immunomodulatory effects, impacting on the immune system both locally and systemically. The gut microbiota are able to affect the efficiency of immunotherapy, mainly acting as inhibitors at immune checkpoints. The effects of immunotherapy may be modulated using traditional probiotic strains and/or next generation probiotics, such as Akkermansia municiphila. It is possible that probiotics might enhance the efficiency of immunotherapy based on PD-1/PD-L1 and CTLA-4 but more data are needed to confirm this speculation. Indeed, although there is experimental evidence for the efficacy of several strains, the health-promoting effects of numerous probiotics have not been demonstrated in human patients and furthermore the potential risks of these products, particularly in oncologic patients, are rarely mentioned.

A Comparative Study of Automatic Localization Algorithms for Spherical Markers within 3D MRI Data

Localization of features and structures in images is an important task in medical image-processing. Characteristic structures and features are used in diagnostics and surgery planning for spatial adjustments of the volumetric data, including image registration or localization of bone-anchors and fiducials. Since this task is highly recurrent, a fast, reliable and automated approach without human interaction and parameter adjustment is of high interest. In this paper we propose and compare four image processing pipelines, including algorithms for automatic detection and localization of spherical features within 3D MRI data. We developed a convolution based method as well as algorithms based on connected-components labeling and analysis and the circular Hough-transform. A blob detection related approach, analyzing the Hessian determinant, was examined. Furthermore, we introduce a novel spherical MRI-marker design. In combination with the proposed algorithms and pipelines, this allows the detection and spatial localization, including the direction, of fiducials and bone-anchors.

Virucidal Efficacy of Household Dishwashers

Not only since SARS-CoV-2, have transmission routes of viruses been of interest. Noroviruses e.g., can be transmitted via smear infection, are relatively stable in the environment and very resistant to chemical disinfection. Some studies determined the virucidal efficacy of laundering processes, but few studies focused on the virucidal efficacy of dishwashing processes. Here, especially consumer related conditions are of interest. Households for example are a hotspot of norovirus infection and thus a sufficient reduction of these and other viruses from dishes must be insured to avoid an infection via this route. The likelihood of such an event should not be underestimated, since it was shown that the washing machine can be a reservoir for the transmission of extended spectrum beta-lactamase producing bacteria in newborns. Although viruses do not replicate in these devices a transmission via contaminated cutlery e.g., cannot be excluded. Using a consumer related approach to determine the virucidal efficacy of dishwashers, we found a combination of a bleach containing dishwasher detergent, a cleaning temperature of 45 °C for 45 min and a rinsing temperature of 50 °C, to be sufficient to reduces viral titer of bovine corona virus, murine norovirus and modified vaccinia virus by 4.8, 4.2 and 3.8 logarithmic stages respectively.