Mitigating fatigue damage and improving grasping performance are the two main challenging tasks of applying the soft manipulator into industrial production. In this paper, the grasping position optimization-based control strategy is proposed for the soft manipulator and the corresponding characteristics are studied theoretically and experimentally. Specifically, based on the simulation, the resultant stress of step-function-type channels at the same pressure condition that was smallest compared with those of sine-function- and ramp-function-type channels, hence, a pneumatic network with step-function-type channels was selected for the proposed soft manipulator. Furthermore, in order to improve the grasping performance, the kinematics, mechanical, and grasping modeling for the soft manipulator were established, and a control strategy considering the genetic algorithm is introduced to detect the optimal position of the soft manipulator. The corresponding fabrication process and experiments were conducted to cross verify the results of the modeling and the control strategy. It is demonstrated that the internal pressure of the soft manipulator was reduced by 13.05% at the optimal position, which effectively helped mitigate the fatigue damage of the soft manipulator and prolonged the lifespan.