The article is devoted to the problem of finding the Proto-Slavic homeland. Based on data from historical sources, archeology, philology, anthropology, materials of genetic studies of various populations of Slavs, an attempt made to establish the area of formation of the Proto-Slavs. As one of the fundamental elements in the ethnogenesis of the Proto-Slavs, the bearer of the Pomeranian culture considered, presumably based on the substrate of the Western Balts and, possibly, the Venetes linguistically close to them. Based on a retrospective analysis, work done to summarize information about the Venetes as possible migrants from the Asia Minor peninsula, in connection with which an attempt made to establish the chronology of their resettlement across Europe. The area of formation of the Proto-Slavs considered in the context of the existing trade routes that connected the tribes living in the Vistula basin with the Mediterranean, the Eastern Baltic, the Dnieper basin, Germany and Gaul. It was shown that the expansion of the Velbar culture led to the division of the area of the Proto-Slavs, which resulted in their cultural differentiation. This approach allows us to explain the presence of Proto-Slavs in the polyethnic Przeworsk, Zarubinets and Chernyakhov cultures.