Initial Mix-and-Match COVID-19 Vaccination Perceptions, Concerns, and Side Effects across Canadians

Research indicates that mixing the first two doses of COVID-19 vaccine types (i.e., adenoviral vector and mRNA) produces potent immune responses against the coronavirus, but it is unclear how individuals may perceive these benefits, or whether there are different concerns compared to individuals who received two doses of the same vaccine. This research examines the demographic characteristics, psychological perceptions, and vaccination-related opinions and experiences of a large Canadian sample (N = 1002) who had received two initial doses of any COVID-19 vaccine combination. Participants included 791 (78.9%) who received two doses of the exact same brand and type of vaccine, 164 (16.4%) who received two doses of the same type of vaccine (i.e., either mRNA or adenoviral vector) but from different brands (e.g., Pfizer-BioNTech + Moderna), and 47 (4.7%) who received two doses from different types and brands of vaccine (e.g., Oxford-AstraZeneca + Pfizer-BioNTech). Results showed that, after the first vaccine dose, participants who received an adenoviral vector vaccine (e.g., Oxford-AstraZeneca) experienced the highest number of common side effects, and more severe levels of each side effect compared to those who received an mRNA vaccine (e.g., Pfizer-BioNTech or Moderna). After the second dose, participants who received Moderna as their second vaccine experienced the highest number of and most severe side effects, regardless of whether they received Moderna, Pfizer-BioNTech, or Oxford-AstraZeneca as their first dose. Real-world implications of these findings are discussed.

Safety and Immunogenicity of Mix-Match of Vaccines -Covishield and Covaxin – a Pilot Study

This single-center prospective observational study was conducted to assess the safety and immunogenicity of combination vaccines AstraZeneca’s ChAdOx1-nCov-19 (Covishield in India) and inactivated whole virion BBV152 (Covaxin). A total of 330 unvaccinated healthy volunteers were screened for SARS-COV2 seropositivity. RT PCR tests were conducted for seronegative volunteers (n =44). They were randomly assigned to four groups and given either same or mixed vaccines at an interval of 4 weeks between the two doses. Mix and match of vaccines did not evoke any adverse events. Combination of vaccines elicited similar immune responses in 4 groups. They were further studied dividing into homologous and heterologous vaccine groups. In Conclusion, Combination vaccines are safe and immunogenic and heterologous vaccines elicit better immunogenic response.

Refleksi Guru Terhadap Problem Keragaman Media Daring dalam Pembelajaran Sejarah

This article aims to explain the problem of the variety of online media used by teachers during online history learning. This problem arises because there is no standard provision for online media that must be used by teachers. So that teachers can freely take advantage of various free and paid online media or even develop media independently. The research method used is a survey using a questionnaire distributed by random sampling technique for one month to 41 respondents spread over nine provinces in Indonesia. The results of the descriptive statistical analysis show that teachers mix and match the use of online media in accordance with the learning objectives. Another finding is that it is understood that each media has its own advantages and disadvantages. A relatively similar impression in sorting and selecting various online media is described in this article. The most popular online media for planning are Google Classroom and WhatsApp Group. As for the implementation of learning, namely Zoom Meeting and Google Meeting. Online media for learning evaluation using Quizizz. Artikel ini bertujuan untuk menjelaskan persoalan ragam media daring yang digunakan oleh guru selama pembelajaran sejarah daring. Persoalan ini muncul karena tidak adanya ketentuan baku akan media daring yang wajib digunakan oleh guru. Sehingga guru dapat leluasa memanfaatkan berbagai media daring yang gratis maupun berbayar atau bahkan menggembangkan media secara mandiri. Metode penelitian yang digunakan yaitu survei dengan menggunakan angket yang disebarkan dengan teknik random sampling selama satu bulan kepada 41 responden yang tersebar di sembilan provinsi di Indonesia. Hasil dari analisis statistis deskriptif menunjukkan bahwa guru memadupadankan penggunaan media daring yang sesuai dengan tujuan pembelajaran. Temuan lainnya yaitu telah dipahami bahwa setiap media memiliki kelebihan dan kekuranganya masing-masing. Kesan yang relatif sama dalam memilah dan memilih berbagai media daring diuraikan dalam artikel ini. Media daring yang paling diminati untuk perencanaan yaitu Google Classroom dan WhatsApp Group. Sedangkan untuk pelaksanaan pembelajaran yaitu Zoom Meeting dan Google Meeting. Media daring untuk evaluasi pembelajaran menggunakan Quizizz.

Safety and Immunogenicity of Combination of Vaccines – Covishield and Covaxin – a Pilot Study

This single-center prospective observational study was conducted to assess the safety and immunogenicity of combination vaccines AstraZeneca’s ChAdOx1-nCov-19 (Covishield in India) and inactivated whole virion BBV152 (Covaxin). A total of 330 unvaccinated healthy volunteers were screened for SARS-COV2 seropositivity. RT PCR tests were conducted for seronegative volunteers (n =44). They were randomly assigned to four groups and given either same or mixed vaccines at an interval of 4 weeks between the two doses. Mix and match of vaccines did not evoke any adverse events. Combination of vaccines elicited similar immune responses in 4 groups. In Conclusion, Combination vaccines are safe and immunogenic.