Design of Colleges and Universities Mechanical Simulation System Based on Computer VR

With the rapid development of network technology, the traditional teaching methods can not adapt to the teaching objectives of colleges. VR has become a basic teaching tool in Colleges, which can help teachers complete teaching. At the same time, VR can improve students’ interest in learning, which can help students explore more subject knowledge. Mechanical specialty is an important subject, which requires simulation and other learning. At present, there are many kinds of software in the world, which can carry out mechanical simulation, such as SolidWorks, 3DMAX, flash and so on. Through the relevant software, colleges can design the mechanical simulation system, which can help to set up the whole process resource library in a certain field. Through the resource library, colleges can help to complete the three-dimensional entity display of equipment, which can be displayed in an all-round way. Through VR, we can help students understand the real work scene, which can help improve the students’ mechanical design ability. At the same time, through computer VR, colleges can help students learn more about the working scene of mechanical design. Firstly, this paper analyzes the importance of mechanical simulation system design. Then, this paper designs the related system content. Finally, some suggestions are put forward.

The Construction of a Digital Resource Library of English for Higher Education Based on a Cloud Platform

This paper conducts in-depth research and analysis on the construction of an English digital resource library for higher education through the cloud platform. The cloud platform allows the English resource library to achieve integration, efficiency, scalability, and interactivity and then solves the problems of how to realize the co-construction and sharing of resources among multiple platforms in vocational institutions and improve the utilization rate of resources. The construction of the English resource library in higher vocational institutions cannot be separated from the collaboration between institutions and enterprises, and institutions must face up to the problems existing in the construction of the current resource library. Firstly, the requirements of various aspects of the higher vocational English digital resource library system are given from three aspects, functional requirements, performance requirements, and operational requirements, in strict accordance with the requirement analysis steps; secondly, the overall technical architecture and network topology architecture of the education cloud platform where the higher vocational English digital resource library system is located are analyzed and given in general to ensure the security, scalability, and ease of operation of this platform and then the resource collection and resource storage. The application of cloud computing technology can solve the problems of difficulty in obtaining teaching resources, insufficient storage space, limited communication, and slow circulation; it can realize the integration and integrated management of various resources through technologies such as networking, virtualization, and distributed storage. Finally, based on the optimization strategies proposed in this paper, the core modules of the higher vocational English digital resource library system are designed and implemented, and some important and representative interfaces and source codes are demonstrated. To ensure the operation performance, the situation of multiple users operating the higher-level English digital resource library system at the same time is simulated, and the overall performance of the higher-level English digital resource library system is evaluated for the common operations such as uploading resource files, downloading resource files, and querying resource files, which confirms the rationality of the design strategy in this paper and greatly improves the user experience and increases the utilization rate of teaching resources.

Novel non-nucleoside inhibitors of Zika virus polymerase identified through the screening of an open library of anti-kynetoplastid compounds

Zika virus (ZIKV) is a mosquito-borne pathogen responsible for neurological disorders (Guillain-Barré syndrome) and congenital malformations (microcephaly). Its ability to cause explosive epidemics, such as that of 2015-16, urges the identification for effective antiviral drugs. Viral polymerase inhibitors constitute one of the most successful fields in antiviral research. Accordingly, the RNA-dependent RNA polymerase activity of flavivirus NS5 protein provides a unique target for the development of direct antivirals with high specificity and low toxicity. Here we describe the discovery and characterization of two novel non-nucleoside inhibitors of ZIKV polymerase. These inhibitors, TCMDC-143406 ( 6 ) and TCMDC-143215 ( 15 ), were identified through the screening of an open resource library of anti-kinetoplastid compounds using a fluorescence-based polymerization assay based on ZIKV NS5. The two compounds inhibited ZIKV NS5 polymerase activity in vitro and ZIKV multiplication in cell culture (EC 50 values of 0.5 and 2.6 μM for 6 and 15 , respectively). Both compounds also inhibited the replication of other pathogenic flaviviruses, namely West Nile virus (WNV; EC 50 values of 4.3 and 4.6 μM for 6 and 15 , respectively) and dengue virus 2 (DENV-2; EC 50 values of 3.4 and 9.6 μM for 6 and 15 , respectively). Enzymatic assays confirmed that the polymerase inhibition was produced by a non-competitive mechanism. Combinatorial assays revealed an antagonistic effect between both compounds, suggesting that they would bind to the same region of ZIKV polymerase. The non-nucleoside inhibitors of ZIKV polymerase here described could constitute promising lead compounds for the development of anti-ZIKV therapies and eventually broad-spectrum anti-flavivirus drugs.

Pemberdayaan Masyarakat melalui Perpustakaan Desa Berbasis Inklusi Sosial (Studi Kasus Perpustakaan “Sumber Ilmu” Desa Marga Sakti Kabupaten Musirawas)

Libraries can play a more role and can contribute in terms of community empowerment, closer, invite and empower the community. One way to get closer to the community is that the library can use the concept of inclusion to achieve its goals as a principle of lifelong learning. Inclusion-based libraries are libraries that facilitate the community in developing their potential by seeing cultural diversity, willingness to accept change, and offering opportunities to try, protect and fight for culture and human rights. This has been done by the Library of Science Resources in Marga Sakti Village, Musi Rawas Regency, with the concept of a Village Library Based on Social Inclusion, which has made the library an institution that can empower the community through productive activities such as making bitter melon chips, cultivating crickets, providing internet access for the community, Karang Taruna activities by establishing Youth Bands, PKK activities centered in libraries, storytelling activities, mobile libraries, establishing reading villages and others. Of the many activities above, this indicates that the library has become the central activity of the village community and as a concrete manifestation that the Marga Sakti Village Resource Library has implemented the concept of Social Inclusion.

Developing 21st Century School Media Resource Libraries for Singapore

In light of global calls for emphasizing innovative thinking and creative problem solving in elementary and secondary schools and a more collaborative role for school media resource libraries to support the new focus, a taskforce of four faculty members from the Division of Information Studies of Nanyang Technological University undertook to assess the status of a selected group of thirteen media resource libraries in Singapore. Data obtained from questionnaires and focus groups indicate that for Singapore's School Media Resource Libraries to play a significant role in supporting the new educational focus some important changes are needed. Recommendations from the taskforce include a change in status of the School Media Resource Library and its supervisor, additional training and education for these supervisors, improved access and connectivity for inter-school cooperation, and more collaborative collection management policies.