Mandatory Corporate Human Rights Due Diligence Models: Shooting Blanks?

The major stakeholders, including states (at least, in the global North) and transnational corporations (TNCs), have radically changed their attitude to the idea of mandatory human rights due diligence in the last decade. By asking what is behind these good intentions, and whether the mandatory corporate human rights due diligence models enforced so far are effective or represent an exercise in shooting blanks, and by combining a legal positivistic perspective with studies on governance and the production of knowledge, this article contributes to the legal and socio-legal assessment of these changes Assessing the effectiveness of mandatory corporate human rights due diligence, this article discusses the inherent or implied features of this regulatory tool which restrict its ability to serve as an instrument to protect human rights. A special focus is made on two main restrictions that are specific for human rights due diligence: the regulatory boundary revealed in the auxiliary character of due diligence and its limed ability to serve as a standard of conduct, and the epistemic boundary, deriving from the conflicting role of companies as the architects and executives of knowledge production. To a certain extent, the legislative process can counterbalance some of these restrictions by setting up the substantive, precise obligations of companies, and by creating mechanisms of control and remediation. However, the analysis of nine different instruments reveals that neither states, nor the EU have used the potential of the regulatory force.

Parental Conflicting Role Mediates Regulation of The Chromatin Structure in The Mouse Zygote

Parental pronuclei (PN) are asymmetrical in several points but the underlying mechanism for this is still unclear. Recently, a theory has been become broadly accepted that sperm are more than mere vehicles to carry the paternal haploid genome into oocytes. Here, in order to reveal the formation mechanisms for parental asymmetrically relaxed chromatin structure in zygotes, we investigated histone mobility in parthenogenetic-, androgenic-, ROSI-, ELSI-, tICSI-, and ICSI-zygotes with several numbers of PNs with the use of zygotic fluorescence recovery after photobleaching, a method previous established by our group. The results showed that sperm played a role to cause chromatin compaction in both parental PNs. Interestingly, during spermiogenesis, male germ cells acquired this ability and its resistance. On the other hand, oocytes harbored chromatin relaxation ability. Furthermore, the chromatin relaxation factor was competed for between PNs. Thus, these results indicated that the parental asymmetrically relaxed chromatin structure was established as a result of a competition between the PNs for the chromatin relaxation factor that opposed the chromatin compaction effect by sperm. Together, it was suggested that parental germ cells cooperated for their just arisen newborn zygotes by playing a distinct role in the regulation of chromatin structure.

CXC chemokine ligand 16: a Swiss army knife chemokine in cancer

Today, cancer is one of the leading causes of death worldwide. Lately, cytokine and chemokine imbalances have gained attention amongst different involved pathways in cancer development and attracted much consideration in cancer research. CXCL16, as a member of the CXC subgroup of chemokines, has been attributed to be responsible for immune cell infiltration into the tumour microenvironment. The aberrant expression of CXCL16 has been observed in various cancers. This chemokine has been shown to play a conflicting role in tumour development through inducing pro-inflammatory conditions. The infiltration of various immune and non-immune cells such as lymphocytes, cancer-associated fibroblasts and myeloid-derived suppressor cells by CXCL16 into the tumour microenvironment has complicated the tumour fate. Given this diverse role of CXCL16 in cancer, a better understanding of its function might build-up our knowledge about tumour biology. Hence, this study aimed to review the impact of CXCL16 in cancer and explored its therapeutic application. Consideration of these findings might provide opportunities to achieve novel approaches in cancer treatment and its prognosis.

Semantic Analysis of Cultural Heritage News Propagation in Social Media: Assessing the Role of Media and Journalists in the Era of Big Data

In the era of big data, within the intense environment of social media, the effective communication of cultural heritage initiatives is considered of equal or—in some cases—even greater importance than heritage data themselves. Media and journalists play a critical and in some cases conflicting role in audience engagement and the sustainable promotion of cultural heritage narratives within the social media environment. The aim of this study was to assess the role of media and journalists in propagating cultural heritage news through social media platforms, and the narratives they tend to create in the digital public sphere. A qualitative approach is employed as a means of examining in-depth specific narratives, their meaning(s) and connotation(s), using semantic analysis.

Professional roles of general practitioners, community pharmacists and specialist providers in collaborative drug deprescribing - a qualitative study

Background: Collaborative care approaches between general practitioners (GPs) and pharmacists have received international recognition for medication optimisation and deprescribing efforts. Although even specialist providers have been shown to influence deprescribing, their profession so far remains omitted from collaborative care approaches for medication optimisation. Similarly, while explorative studies on role perception and collaboration between GPs and pharmacists grow, interaction with specialists for medication optimisation is neglected. Our qualitative study therefore aims to explore GPs`, community pharmacists` and specialist providers` role perceptions of deprescribing, and to identify interpersonal as well as structural factors that may influence collaborative medication optimisation approaches. Method: Seven focus-group discussions with GPs, community pharmacists and community specialists were conducted in Hesse and Lower Saxony, Germany. The topic guide focused on views and experiences with deprescribing with special attention to inter-professional cooperation. We used conventional content analysis following an inductive-deductive approach. Results: Our exploration of role perceptions revealed factors influencing deprescribing collaboration on both interpersonal and structural levels. On interpersonal level, conflicting role positions exposed in clashes of perceived authority, while conflicting role functions were indicated by disagreement on responsibility for deprescribing tasks between stakeholder groups, and resulted in underutilisation of services. Lacking communication was reported as a general barrier to cooperation. On a structural level, missing transparency on medication information across providers and deficient reimbursement for medication optimisation activities emerged as most pronounced obstacles for successful collaborative deprescribing. Also, unclear definition of task division between professional groups provoked difficulties. Conclusion: Revealing relevant stakeholders` role perceptions on their responsibilities and delimitations for joint deprescribing is a prerequisite for collaborative care approaches. Our study revealed several preconditions for joint deprescribing action that emerge from the German setting, but may as well inform other health-systems. As such, necessary medication transparency may be enabled by sector-wide electronic health records. For clarification of role definitions, joint training sessions across stakeholder groups may strengthen future cooperation. Finally, even redefining professional roles should be considered to strengthen GPs` regulatory functions and promote a continuity of care.

The disparate roles of accounting in an amateur sports organisation

Purpose The purpose of this paper is to examine an ongoing process of logic assimilation within an amateur sports organisation (ASO) called the Gaelic Athletic Association (GAA). It seeks to develop our understanding of how forms of accounting mitigated (or exacerbated) the tensions that arose among GAA members due to the consequences of the assimilation of select elements of a professional logic and a commercial logic within its traditionally dominant social welfare logic. Design/methodology/approach Interviews were undertaken with representatives and members of the GAA to understand the effects of growing commercialisation and professionalisation on the organisation’s traditional amateur status and social mission. In particular, the authors sought to understand how accounting, in the form of financial reporting, influenced the extent of the tensions that arose. Interviews were supported by an extensive collection of podcasts and news articles that discussed this topic. Findings The paper’s findings offer unique empirical insights into the role played by forms of accounting in the maintenance of amateurism within an ASO. It reveals the conflicting role of financial reporting within the GAA whereby it was used by the GAA’s management to ease member concerns surrounding logic assimilation while simultaneously being ignored by clubs and counties to facilitate payments to managers thereby eroding the amateur status of Gaelic Games. Originality/value The paper is unique in its exploration of logic assimilation within a form of hybrid organisation that has previously been unexamined in the accounting literature. It extends extant understandings of how accounting influences the co-existence of potentially conflicting logics. The paper also discusses the implications of what accounting makes visible and keeps invisible on the longevity of the traditionally dominant social welfare logic within an ASO.