Function and Plasticity of Electrical Synapses in the Mammalian Brain: Role of Non-Junctional Mechanisms

Electrical transmission between neurons is largely mediated by gap junctions. These junctions allow the direct flow of electric current between neurons, and in mammals, they are mostly composed of the protein connexin36. Circuits of electrically coupled neurons are widespread in these animals. Plus, experimental and theoretical evidence supports the notion that, beyond synchronicity, these circuits are able to perform sophisticated operations such as lateral excitation and inhibition, noise reduction, as well as the ability to selectively respond upon coincident excitatory inputs. Although once considered stereotyped and unmodifiable, we now know that electrical synapses are subject to modulation and, by reconfiguring neural circuits, these modulations can alter relevant operations. The strength of electrical synapses depends on the gap junction resistance, as well as on its functional interaction with the electrophysiological properties of coupled neurons. In particular, voltage and ligand gated channels of the non-synaptic membrane critically determine the efficacy of transmission at these contacts. Consistently, modulatory actions on these channels have been shown to represent relevant mechanisms of plasticity of electrical synaptic transmission. Here, we review recent evidence on the regulation of electrical synapses of mammals, the underlying molecular mechanisms, and the possible ways in which they affect circuit function.

Design and Modeling of Viscoelastic Layers for Locomotive Wheel Damping

Rail–wheel interaction is one of the most significant and studied aspects of rail vehicle dynamics. The vibrations caused by rail–wheel interaction can become critical when the radial, lateral and longitudinal loads of the vehicle, cargo and passengers are experienced while the vehicle is in motion along winding railroad paths. This mainly causes an excessive production of vibrations that may lead to discomfort for the passengers and shortening of the life span of the vehicle’s body parts. The use of harmonic response analysis (HRA) shows that the wheel experiences high vibrational amplitudes from both radial and lateral excitation. The present study describes a numerical and experimental design procedure that allows mitigation of the locomotive wheel resonance during radial and lateral excitations through viscoelastic layers. It is proven that these high frequencies can be reduced through the proper design of damping layer mechanisms. In particular, three parametric viscoelastic damping layer arrangements were analyzed (on the web of both wheel sides, under the rim of both wheel sides and on the web and under the rim of both wheel sides). The results demonstrate that the correct design and dimensions of these viscoelastic damping layers reduce the high-amplitude resonance peaks of the wheel successfully during both radial and lateral excitation.

Cell and circuit origins of fast network oscillations in the mammalian main olfactory bulb

Neural synchrony generates fast network oscillations throughout the brain, including the main olfactory bulb (MOB), the first processing station of the olfactory system. Identifying the mechanisms synchronizing neurons in the MOB will be key to understanding how network oscillations support the coding of a high-dimensional sensory space. Here, using paired recordings and optogenetic activation of glomerular sensory inputs in MOB slices, we uncovered profound differences in principal mitral cell (MC) vs. tufted cell (TC) spike-time synchrony: TCs robustly synchronized across fast- and slow-gamma frequencies, while MC synchrony was weaker and concentrated in slow-gamma frequencies. Synchrony among both cell types was enhanced by shared glomerular input but was independent of intraglomerular lateral excitation. Cell-type differences in synchrony could also not be traced to any difference in the synchronization of synaptic inhibition. Instead, greater TC than MC synchrony paralleled the more periodic firing among resonant TCs than MCs and emerged in patterns consistent with densely synchronous network oscillations. Collectively, our results thus reveal a mechanism for parallel processing of sensory information in the MOB via differential TC vs. MC synchrony, and further contrast mechanisms driving fast network oscillations in the MOB from those driving the sparse synchronization of irregularly-firing principal cells throughout cortex.

Cell and circuit origins of fast network oscillations in the mammalian main olfactory bulb

Neural synchrony generates fast network oscillations throughout the brain, including the main olfactory bulb (MOB), the first processing station of the olfactory system. Identifying the mechanisms synchronizing neurons in the MOB will be key to understanding how network oscillations support the coding of a high-dimensional sensory space. Here, using paired recordings and optogenetic activation of glomerular sensory inputs in MOB slices, we uncovered profound differences in principal mitral cell (MC) vs. tufted cell (TC) spike-time synchrony: TCs robustly synchronized across fast- and slow-gamma frequencies, while MC synchrony was weaker and concentrated in slow-gamma frequencies. Synchrony among both cell types was enhanced by shared glomerular input but was independent of intraglomerular lateral excitation. Cell-type differences in synchrony could also not be traced to any difference in the synchronization of synaptic inhibition. Instead, greater TC than MC synchrony paralleled the more periodic firing among resonant TCs than MCs and emerged in patterns consistent with densely synchronous network oscillations. Collectively, our results thus reveal a mechanism for parallel processing of sensory information in the MOB via differential TC vs. MC synchrony, and further contrast mechanisms driving fast network oscillations in the MOB from those driving the sparse synchronization of irregularly-firing principal cells throughout cortex.

The Study on Nonlinear Model of Pantograph-catenary Coupling system for Straddle-type Monorail

Based on the Lagrange equation, the linear and nonlinear dynamic models of straddle monorail pantograph considering the lateral vibration of bogie are derived. On this basis, the lateral coupling dynamic model of pantograph-catenary is established. Newmark method is used to solve the pantograph-catenary coupling dynamic model. In order to evaluate the applicability of the two models，this paper analyzed the contact force response of two model with different speeds. The reasearch show that when the speed is below 40 km/h, the contact forces of nonlinear model and linear model can reflects the lateral excitation of the finger plate. When the speed exceeds 40 km/h, only the nonlinear model can reflect the lateral excitation of finger palte, the nonlinear pantograph-catenary coupling dynamics model is more suitable to the straddle-type monorail pantograph-catenary coupling research.

Nonlinear Stochastic Analysis of Footbridge Lateral Vibration Based on Probability Density Evolution Method

Footbridge lateral vibration remains an unsolved problem and is characterized by the following: (1) pedestrians are sensitive to bridge vibration, which causes the pedestrian’s excitation being dependent on the bridge vibration; (2) pedestrian lateral excitation is a stochastic process rather than a perfect periodic load. Therefore, footbridge lateral vibration is essentially a complex nonlinear stochastic vibration system. Thus far, an effective method of dealing with such nonlinear stochastic vibration of footbridges remains lacking. A framework based on the probability density evolution (PDE) method is presented. For the mathematical model, the parameter resonance model is used to describe the pedestrian-bridge interaction while treating the pedestrian lateral excitation as a narrow-band process. For the analysis method, PDE is used to solve the nonlinear stochastic equations in combination with the number theoretical and finite difference methods. The proposed method establishes a new approach in studying footbridge lateral vibration. First, PDE based on the small sample strategy avoids the large amount of computation. Second, the randomness of both structural parameters and pedestrian lateral excitation could be taken into consideration by the proposed method. Third, based on the probability results with rich information, the serviceability, dynamic reliability, and random stability analyses are realized in a convenient manner.

Defects Detection and Localization in Underwater Plates Using Laser Laterally Generated Pure Non-Dispersive S0 Mode

When working in humid environments, corrosion defects are easily produced in metallic plates. For defect detection in underwater plates, symmetric modes of Lamb waves are widely used because of their characteristics including long propagating distance and high sensitivity to defects. In this study, we extend our previous work by applying the laser laterally generated S0 mode to detection and localization of defects represented by artificial notches in an aluminum plate immersed in water. Pure non-dispersive S0 mode is generated in an underwater plate by lateral laser source irradiation and its fd (frequency·thickness) range is selected by theoretical calculation. Using this lateral excitation, the S0 mode is enhanced; meanwhile, the A0 mode is effectively suppressed. The mode-converted A0 mode from the incident S0 mode is used to detect and localize the defect. The results reveal a significantly improved capability to detect defects in an underwater plate using the laser laterally generated S0 mode, while that using A0 is limited due to its high attenuation. Furthermore, owing to the long propagating distance and the non-dispersion characteristics of the S0 generated by the lateral laser source, multiple defects can also be detected and localized according to the mode conversion at the defects.