The study investigated the challenges faced by the Palestinian Authority Institutions (PNA) in their practice of Human Resource Management. It adopted a qualitative approach based on a review of relevant literature to find out the major challenges handicapping the efforts to improve HRM in the West Bank in Palestine. The study reflected that with a specific focus on Palestine, the daily practice of HRM is a real challenge especially under the Israeli occupation and the different strategies Israel employs to destroy any improvement plans. The study showed that in the era of global technology, the Palestinian National Authority and its organisations in the West Bank are facing both internal and external challenges, namely the low organisational position of the management of human resources and its confinement to basic functions. In addition, the Procedural aspects, lack of planning and developmental aspects, and limitation of their practice in routine matters related to employment, calculation of salaries and dues, as well as follow-up and permits which constitute a significant challenge. Moreover, the external challenges include the Israeli occupation, which has a major role in these challenges as the occupation prevents public employees of different positions and deputies from reaching their workplaces by dividing the cities of Palestine, military checkpoints, and frequent arrests of ministers and legislators.