Peer review declaration

All papers published in this volume of Journal of Physics: Conference Series have been peer reviewed through processes administered by the Editors. Reviews were conducted by expert referees to the professional and scientific standards expected of a proceedings journal published by IOP Publishing. • Type of peer review: Double-blind or Triple-blind (depends on the paper) • Conference submission management system: WordPress Abstract Submission System Plugin: “WP Abstracts Pro” • Number of submissions received: 85 • Number of submissions sent for review: 73 • Number of submissions accepted: 35 • Acceptance Rate (Number of Submissions Accepted / Number of Submissions Received X 100): 41 • Average number of reviews per paper: 2.6 • Total number of reviewers involved: 57 • Any additional info on review process: - • Contact person for queries: Name : Mirosław Szala Affiliation: Lublin University of Technology, Poland Email : [email protected]

Living with deafblindness during COVID-19: An international webinar to facilitate global knowledge translation

Arguably, individuals living with deafblindness are among the hardest hit by the effects of the corona virus disease of 2019 (COVID- 19), given the importance of the sense of touch for their ability to interact with the world. To address this challenge, it is imperative to facilitate the implementation of evidence- and experience-based recommendations, and to improve knowledge translation on a global scale. Deafblind International organized a webinar to provide a platform where participants could exchange experiences and solutions to overcome the challenges created by the arrival of COVID-19, in order to facilitate information exchange among stakeholders in deafblindness during this pandemic. We present an overview of its content here and place the summarized themes in context with existing research literature. Abstract submission was open for 4 weeks in May 2020, resulting in 30 submissions from 13 countries across 5 continents. Of the 26 presenter teams, 9 (35%) had a co-presenter that was living with deafblindness themselves. The number of individual participants across all sessions ranged from 55 to 140 ( M = 98), with a total of 3709 session registrations overall, and the organizers estimate a total attendance of around 400 participants. Based on extensive field notes taken during the webinar, and repeated viewing of the recordings, qualitative description allowed the team to synthesize eight principal themes across the event: access to information, communication, service accessibility, adaptations to service delivery, online safety and security, physical distancing, mental health and research. The first Deafblind International webinar was able to fill an important gap by bringing together a variety of stakeholders in deafblindness across the globe. The event created a sense of group membership and peer support, brought the participants, researchers, the professionals as well as their service agencies closer together and generated a sense of hope and collaboration.

A Unique Case of Corticomedullary Mixed Tumor Composed of Both Adrenal Cortical Cells and Pheochromocytes

Introduction or Background: Corticomedullary mixed tumors of the adrenal gland was first described in 1969 by Mathison and Waterhouse. It is defined as a single tumor mass of the adrenal gland that histopathologically has presence of adrenal cortical and medullary cells. Such mixed tumors involving the cortical and medullary components of the adrenal glands are very rare. Clinical Case (including diagnostic evaluation, treatment, and follow-up):A 67 year old woman with a history of hypertension and osteoporosis presents for incidental adrenal adenoma. Hypertension was controlled well with olmesartan 40mg, hctz 25mg, and amlodipine 2.5mg. Abdominal CT scan showed a 2.6 cm enhancing left adrenal nodule with delayed wash- out phase. Biochemical testing showed elevated plasma free metanephrine (132pq/ml, n < or = 57pq/ml) and abnormal 1mg dexamethasone suppression test (10.4mcg/dL, n <2mcg/dL). ACTH was suppressed. Patient underwent left adrenalectomy, after pretreatment with doxazosin. Surgical pathology report showed an unusual neoplasm consisting of a single nodule composed of intermixed aggregates of cortical cells and pheochromocytes displaying morphologic features of adrenal adenoma and pheochromocytoma. Also intermixed with the adenoma was a 3mm myelolipoma. Post surgery, the patient was treated with hydrocortisone for symptoms of adrenal insufficiency. Post surgery, she was able to stop amlodipine and hctz and is on 10 mg olmesartan on alternate days.. She remains on a weaning dose of hydrocortisone at the time of abstract submission. Clinical Lesson(s) or Conclusion(s) (emphasizing the learning point[s] and implications for clinical practice)This unique case report highlights the importance of appropriate workup for incidental adrenal adenoma and keeping in mind the rare possibility of mixed endocrine tumours. A single mixed tumor of the adrenal gland is rare but exhibits distinct morphologic features of both a cortisol producing tumor along with a pheochromocytoma. Furthermore, a concurrent intermixing of a myelolipoma within an adrenal corticomedullary mixed tumor is rarely reported.

Triggering an Unexpected Earthquake in an Uncoupled Subduction Zone

<p>In the 1970’s, the Shumagin Islands region of the Alaska subduction zone was identified as a seismic gap expected to host a future great (Mw >8.0) earthquake. More recent geodetic data indicate this region is poorly coupled, and the geologic record shows little evidence of past large events - leading to current thinking of the “Shumagin Gap” as a region of low seismic hazard. From July to October 2020 (with aftershocks continuing through the time of this abstract submission in January), a series of earthquakes occurred in this region, potentially incompatible with this low-coupling interpretation. The initial Mw 7.8 plate interface thrust faulting earthquake on July 21st straddled the eastern edge of the Shumagin Gap, followed by an Mw 7.6 strike-slip earthquake on October 19th within the slab under the eastern side of the Shumagin Gap. Stress modeling indicates that this strike-slip earthquake is in fact favored if the Shumagin Gap has low coupling, whereas a highly coupled Shumagin Gap would inhibit that type and location of earthquake. The initial thrust earthquake and its afterslip significantly enhanced the strike-slip stress loading within the subducting slab, helping to trigger that event. We find that although regions such as the Shumagin Gap have a low seismogenic potential for plate interface thrusting, the existence of this decoupled region increases the potential for intra-plate strike-slip faulting in association with more typical subduction earthquakes on adjacent coupled segments of the plate boundary. Therefore, the seismic and tsunami potential near these uncoupled regions might be greater than previously thought.</p>

ICOS Science Conference 2020

<p>A virtual conference can be much more than another lengthy video meeting. The Integrated Carbon Observation System (ICOS) research infrastructure was aiming for 400 participants with a traditional physical conference. Yet the organisers were pleasantly surprised when their virtual Science conference attracted more than 1000 participants. What were the key elements of this success?</p><p>The abstract submission and review process of a virtual event doesn’t have to be different from a face-to-face conference, but the double-anonymous review process used herein was considered one of the main elements of the success, because it allowed several junior scientists, and even PhD students as speakers in plenary sessions. Another benefit of using virtual platform is that it allowed participation even without any own presentation, because there are no travel nor lodging costs. Our conference was also free of charge and without any registration fees, which is in accordance with EU Open Science Policy. This encouraged student - and worldwide participation.</p><p>With regards to the technicalities, selecting well-experienced, professional virtual event organizer as a partner is essential. Keeping track of the work flow between partners and within the organisation team members is easier when the work division is agreed on at the start and a “master file” is created to keep everyone on track. This also allows for any questions and requests to be shared easily, allowing for systematic updates and traceable flow of information. Uploading of presentations two weeks in allocated voluntary practice sessions to be organized for all speakers before the conference. This practice together with professional studio video-streaming team secured running three parallel sessions smoothly throughout conference. In future, those pre-rehearsals could be made mandatory but even with this 50% of speakers practising, no major difficulties in presentations were encountered. Compared to physical conference the timing of parallel sessions succeeded with highest precision that enabled audience to switch between the sessions without missing any of the presentation beginnings nor causing any disturbance to the speaker or delays in the programme.</p><p>A dedicated public text chat in every session was found useful and essential in a virtual conference. This could easily be implemented in any physical conference as well. The chat helped the chair to select questions based on content, and even those questions which did not get floor time were answered afterwards in the chat – either by presenter or other community members. Everybody was getting an equal opportunity to ask their question or making their comment and thus getting their voices to be heard.</p><p>Recording all sessions and having them available online for limited time allowed participants a chance to listen to talks from parallel sessions afterwards, and encouraged participation across time zones.</p><p>The overall participant feedback was positive and encouraging to include some of the virtual elements in the future ICOS conferences even when pandemic situation allows traveling.</p>

The early 2021 Sudden Stratospheric Warming as observed by ADM-Aeolus

<p>Sudden Stratospheric Warmings (SSWs) are dramatic events where the usually-strong wind vortex around the edge of the polar stratosphere temporarily weakens or reverses, causing the polar temperature to rise by tens of Kelvin in just a few days. These events can trigger extreme winter weather outbreaks in Europe and North America, and are thus of significant scientific and practical interest. However, due to the major technical challenges involved in measuring wind from space, the changes in wind structure involved in an SSW have never been directly observed at the global scale, and our understanding of these changes  has instead been developed through the use of point measurements, localised flight tracks and (primarily) computer models and assimilative analyses. Here, we exploit novel measurements from Aeolus, the first satellite capable of observing wind in the upper troposphere and lower stratosphere, to study this process observationally during the major January 2021 SSW. As the event is still ongoing at time of abstract submission, precise details of the changes seen in Aeolus data over the full event cannot be provided; however, data from the first full week of the SSW shows clear observational evidence in Aeolus data of significant and descending-with-time structural changes to the lower stratospheric flow, including reversal of the mean zonal flow, a clear shifting of the vortex centre to a location over northern Russia,  and perhaps early evidence of a developing split of the vortex into two sub-vortices.</p>

Abstract P496: Clot Characteristics in Mechanical Thrombectomy: Interim Analysis of the EXCELLENT Registry

Introduction: Red blood cell (RBC) rich vs fibrin rich clots have different mechanical properties and greater knowledge about clot composition in the context of clinical, imaging, and procedural factors in mechanical thrombectomy (MT) may help with procedural optimization. The EXCELLENT Registry (NCT03685578) is a prospective, global, multi-center, observational registry of EmboTrap as the first line MT device for large vessel occlusion (LVO). We present an interim analysis of clot collected per pass in the registry. Methods: Five hundred thirty-three clot specimens from 376 subjects were collected by 20 sites and sent for analysis by independent Central Labs under standardized protocol. Analysis was interrupted by COVID-19, but the labs were fully operational as of June 2020 and on track to deliver results for 300 subjects in Q4. At the time of abstract submission, composition data for 234 clots from 163 subjects was available. All available data will be presented at the time of the conference. Results: Cardioembolic etiology (n=100) was associated with lower RBC (40.2 vs 47.2%) and higher fibrin content (31.7 vs 26.7%) compared to large artery disease (n=12). Hyperdense/vessel susceptibility sign (78+, 24-, per independent imaging core lab) corresponded to higher mean RBC content (44.4 vs 34.9%). Treatment with IV tPA (60+, 91-) had no clear impact on clot composition (42.3 vs 40.6% RBC; 30.4 vs 30.0% fibrin). Notably, clots retrieved with the first 2 passes of were more RBC rich (42.1 vs 28.0%) and clots retrieved in higher passes had a higher average fibrin content (35.5 vs 29.6%) suggesting that higher fibrin content leads to greater refractoriness. Conclusions: Clot density/susceptibility on baseline imaging, stroke etiology and number of thrombectomy passes were associated with differential clot composition. These findings may have potential implications for the development of better MT strategies.

The gender gap in European neurosurgical conference presentations

OBJECTIVEWithin neurosurgery, there are fewer women than men at all levels. The authors aimed to assess whether opportunities and representation within neurosurgery are proportional to the existing gender gap.METHODSThe authors analyzed the program of the 2019 joint European Association of Neurosurgical Societies (EANS)/Society of British Neurological Surgeons (SBNS) conference to assess the proportions of presentations given through abstract submission and invitation by men and women. They compared proportions to the previous joint conference in 2007 and to the gender proportions of board-certified European neurosurgeons.RESULTSWomen delivered 75/577 (13%) presentations at the 2019 EANS/SBNS conference: 54/283 (19%) abstract submissions and 21/294 (7%) invited presentations. Fifteen of 152 (10%) session chairs were women. This increased significantly from 4/121 (3%) presentations delivered by women in 2007. When only presentations given by neurosurgeons (residents or consultants) were analyzed, the proportion of female speakers increased from 1/111 (1%) in 2007 to 60/545 (11%) in 2019. Pediatrics was the subspecialty with the highest proportion of invited female speakers. Across subspecialties, there were no differences in gender proportions for presentations from abstract submissions. Across the top 5 participating European countries, the proportion of female invited speakers (8%) and chairs (8%) was half the proportion of female board-certified neurosurgeons (16%).CONCLUSIONSThe proportion of women delivering invited presentations and chairing sessions at a European neurosurgical conference is lower than expected from the available pool of board-certified neurosurgeons. The proportion of women participating is higher through application (abstract submission) than through invitation. The higher proportion of presentations from abstract submission may reflect submission from a pool of trainees with a higher proportion of women. The authors suggest implementation of strategies that increase invited speakers from minority groups and have been shown to be effective in other disciplines, such as improving minority group representation in organizing committees.

Using Newly Linked Data to Assess Equity of Out-Of-Pocket Healthcare Costs in Australia

IntroductionDescribing out-of-pocket (OOP) healthcare costs in relation to ability to pay requires multiple linked data sources not previously available. Current estimates of the progressivity of OOP healthcare costs in Australia are based on self-report surveys. Using newly linked Census to administrative income and medical claims data, we aimed to quantify, for the first time, the progressivity of OOP costs for government-subsidised out-of-hospital healthcare in Australia. Objectives and ApproachWe used Australian Census 2011 linked to Personal Income Tax (PIT), Medicare Benefits Schedule (MBS) and Pharmaceutical Benefits Scheme (PBS) data compiled through the Multi-Agency Data Integration Project (MADIP). Personal disposable income was estimated using a combination of PIT data and Census self-reported income, and aggregated across the household to estimate equivalised household income. We estimated annual MBS (out-of-hospital only) and PBS OOP costs as a proportion of equivalised household income, and assessed progressivity by reporting this for each income decile and computing a Kakwani Index. ResultsWe will present findings on progressivity overall, and separately by age, sex and location (incomplete at time of abstract submission). Conclusion / ImplicationsOur study will present one measure regarding the equity of healthcare costs, and help to identify vulnerable or at-risk groups. These findings may inform policy changes on equity in the financing of healthcare. Newly linked data from the MADIP can be used to relate healthcare costs to ability to pay.

Demonstrating the Utility of New Linked National Health Survey and Administrative Data: Secondary CVD Prevention in The Community

IntroductionCardiovascular events are largely preventable though access to timely quality primary health care and use of guideline-recommended medication. However, around half of Australians with cardiovascular disease (CVD) are not receiving best practice treatment. This study aims to identify factors associated with under treatment, using National Health Survey (NHS) linked for the first time to administrative health data. Objectives and ApproachParticipants with self-reported CVD in the NHS 2014-15 were included in the study, with data linked to Medicare (MBS) and pharmaceutical (PBS) data by the Australian Bureau of Statistics through the Multi-Agency Data Integration Project (MADIP). Use of primary and specialist ambulatory care and blood pressure- and lipid-lowering medications and their relation to sociodemographic and health characteristics were quantified using logistic and Poisson regression analyses. Results1100 participants with self-reported CVD were available for analysis, with linkage rates for NHS data to a Person Linkage Spine of 95%. We will present our findings from adjusted regression models (incomplete at time of abstract submission). Conclusion / ImplicationsThe nationally representative linked data developed under this project provides a unique opportunity to quantify and identify points to improve access to best practice CVD care, with the ultimate aim of preventing secondary CVD events in the population. Findings will also inform optimal use of MADIP data by the research community in order to answer questions of national importance and provide robust evidence to drive improvement in health and health care.