Individual Responsibility under Systemic Corruption: A Coercion-Based View

Should officeholders be held individually responsible for submitting to systemically corrupt institutional practices? We draw a structural analogy between individual action under coercive threat and individual participation in systemic corruption, and we argue that officeholders who submit to corrupt institutional practices are not excused by the existence of a systemic coercive threat. Even when they have good personal reasons to accept the threat, they remain individually morally assessable and, in the circumstances, they are also individually blameworthy for actions performed in their institutional capacity.

From Structure to Atoms: Compression/Tension Systems to a Molecular Tensegrity

We reconsider macroscopic structure, including tensegrity structures, as ensembles of compression (C; repulsion) and tension (T; attraction) forces, and fit them to a triangular spectrum. Then, derivative structural analogy is made to the three classes of molecular bonding, as a bridge to microscopic structure. Basic molecular interactions and their “C/T” analogues are ionic bonds (with continuous compression/discontinuous tension), or metallic bonds (with both continuous tension and compression), or covalent bonds (with discontinuous compression/continuous tension—a tensegrity structure). The construction of tensegrity sculptures of particle interactions and the covalent molecules dihydrogen, methane, diborane, and benzene using tension and compression elements follows. We derived and utilized two properties in this analysis: 1) a “simplest tensegrity” subunit structure and 2) interpenetrating, discontinuous compressive members—tension members may also be discontinuous. This approach provides new artistic models for molecules and materials, and may inform future artistic, architectural, engineering and scientific endeavors.

„Staunest Fremdling / Diese Stein an?“ Das Außen des Innen in Tourismus und Idylle

This article examines the structural analogy between the literary idyll and tourism that lies in the specific difference between idyllic and touristic spaces on the one hand and those of a modern, functionally differentiated, and rational everyday life on the other. The peak in the production of literary idylls as well as the onset of tourism in the late 18th and early 19th century can thus be conceptualized as a reaction to experiences of alienation due to emerging processes of modernization. An analysis of Goethe’s Der Wandrer shows however how literary idylls not only helped to shape the tourist gaze, but also reflected on the touristic and idyllic experience as an experience between foreignness, alienation and belonging.

PREPARATION OF DATA FOR FORECASTING AN ORDER IN THE ABSENCE OF INFORMATION FOR PAST PERIODS

Сompanies launching a new product on the market have a high level of uncertainty about the use of existing production facilities in future periods. Uncertainty about the use of existing production capacity in future periods arises from the lack of demand data for past periods. The use of forecasting methods based on historical statistics becomes impossible. The article provides an analysis of the structural analogy method used in the preparation of data to predict the pricing of the product under study. It is proposed to use relevant products as input data for forecasting demand.

FORECASTING ORDERS IN A SINGLE PRODUCTION FOR RELEVANT PRODUCTS

High uncertainty in the use of existing production facilities in a single production arises due to the uncertainty of receiving orders. To predict orders in make-to-order production, it is possible to use the method of structural analogies for the relevant products. The article provides an example of using the method of structural analogy for relevant products. An example of calculating the expected volume of orders for machine-building products (excavator buckets and helicopter engines) is given.

Graph Theoretical Design of Biomimetic Aramid Nanofiber Nanocomposites as Insulation Coatings for Implantable Bioelectronics

An insulation material combining crack and delamination resistance, flexibility, strong adhesion, and biocompatibility is vital for implantable bioelectronic devices of all types. Creating a material with the combination of all these properties is a particularly distinct challenge for implantable electrodes. Here we describe a nanocomposite material addressing these technological challenges based on aramid nanofibers (ANFs) whose unique mechanical properties are complemented by the epoxy resins with strong adhesion to various surfaces. The nanoscale structure of the ANF/epoxy nanocomposite coating replicates the nanofibrous organization of human cartilage, which is known for its exceptional toughness and longevity. The structural analogy between percolating networks of cartilage and ANF was demonstrated using Graph Theory (GT) analysis. The match of multiple GT indexes indicated the near identical organization pattern of cartilage and ANF/epoxy nanocomposite. When compared with the standard insulating material for bioelectronics, Parylene C, the ANF/epoxy nanocomposite demonstrates excellent interfacial adhesion, biocompatibility, and low inflammatory response. This study opens the possibility for the development of insulation materials suitable for different types of electronics for neural engineering and other biomedical applications. Also important, GT analysis makes possible structural characterization of complex biological and biomimetic materials.

First Synthesis of Racemic Trans Propargylamino-Donepezil, a Pleiotrope Agent Able to Both Inhibit AChE and MAO-B, with Potential Interest against Alzheimer’s Disease

Alzheimer’s disease (AD) is a multifactorial neurodegenerative disease towards which pleiotropic approach using Multi-Target Directed Ligands is nowadays recognized as probably convenient. Among the numerous targets which are today validated against AD, acetylcholinesterase (ACh) and Monoamine Oxidase-B (MAO-B) appear as particularly convincing, especially if displayed by a sole agent such as ladostigil, currently in clinical trial in AD. Considering these results, we wanted to take benefit of the structural analogy lying in donepezil (DPZ) and rasagiline, two indane derivatives marketed as AChE and MAO-B inhibitors, respectively, and to propose the synthesis and the preliminary in vitro biological characterization of a structural compromise between these two compounds, we called propargylaminodonepezil (PADPZ). The synthesis of racemic trans PADPZ was achieved and its biological evaluation established its inhibitory activities towards both (h)AChE (IC50 = 0.4 µM) and (h)MAO-B (IC50 = 6.4 µM).

Anticancer Properties of Lobetyolin, an Essential Component of Radix Codonopsis (Dangshen)

Lobetyolin (LBT) is a polyacetylene glycoside found in diverse medicinal plants but mainly isolated from the roots of Codonopsis pilosula, known as Radix Codonopsis or Dangshen. Twelve traditional Chinese medicinal preparations containing Radix Codonopsis were identified; they are generally used to tonify spleen and lung Qi and occasionally to treat cancer. Here we have reviewed the anticancer properties of Codonopsis extracts, LBT and structural analogs. Lobetyolin and lobetyolinin are the mono- and bis-glucosylated forms of the polyacetylenic compound lobetyol. Lobetyol and LBT have shown activities against several types of cancer (notably gastric cancer) and we examined the molecular basis of their activity. A down-regulation of glutamine metabolism by LBT has been evidenced, contributing to drug-induced apoptosis and tumor growth inhibition. LBT markedly reduces both mRNA and protein expression of the amino acid transporter Alanine-Serine-Cysteine Transporter 2 (ASCT2). Other potential targets are proposed here, based on the structural analogy with other anticancer compounds. LBT and related polyacetylene glycosides should be further considered as potential anticancer agents, but more work is needed to evaluate their efficacy, toxicity, and risk–benefit ratio.

Starting small: Exploring the origins of successor function knowledge

Although most U.S. children can accurately count sets by 4 years of age, many fail to understand the structural analogy between counting and number — that adding 1 to a set corresponds to counting up 1 word in the count list. While children are theorized to establish this Structure Mapping coincident with learning how counting is used to generate sets, they initially have an item-based understanding of this relationship, and can infer that, e.g, adding 1 to “five” is “six”, while failing to infer that, e.g., adding 1 to “twenty-five” is “twenty-six” despite being able to recite these numbers when counting aloud. The item-specific nature of children’s successes in reasoning about the relationship between changes in cardinality and the count list raises the possibility that such a Structure Mapping emerges later in development, and that this ability does not initially depend on learning to count. We test this hypothesis in two experiments and find evidence that children can perform item-based addition operations before they become competent counters. Even after children learn to count, we find that their ability to perform addition operations remains item-based and restricted to very small numbers, rather than drawing on generalized knowledge of how the count list represents number. We discuss how these early item-based associations between number words and sets might play a role in constructing a generalized Structure Mapping between counting and quantity.