Molecular Dynamics of Mosquito-Plasmodium vivax Interaction: A Smart Strategy of Parasitism

Parallel to Plasmodium falciparum, P. vivax is a fast emerging challenge to control malaria in South-East Asia regions. Owing to unique biological differences such as the preference for invading reticulocytes, early maturation of sexual stages during the infection, the formation of hypnozoites, unavailability of in-vitro culture, the molecular relation of P. vivax development inside the mosquito host is poorly known. In this chapter, we briefly provide a basic overview of Mosquito-Plasmodium interaction and update current knowledge of tissue-specific viz. midgut, hemocyte, and salivary glands- molecular dynamics of Plasmodium vivax interaction during its developmental transformation inside the mosquito host, in specific.

Digital media, disability and development in the Anglophone Caribbean-social and ethical considerations

Purpose In 2006, the United Nations established the convention on the rights of persons with disabilities. Simultaneously, the UN has adopted the sustainable development goals in 2015 and the 17 goals must be achieved by member states by 2030. Regionally, countries within the Caribbean community have formulated the Kingston Accord (2004) and the Declaration of Petion Ville (2013). Both of these two instruments outlined a regional framework on the issue of persons with disabilities (PWDs). The media, therefore, have axiological roles to play in educating and informing all the stakeholders of these programmes, policies and legislation. It is within this context that this researcher did a qualitative assessment of how the media within Caribbean societies have been aiding the process of developmental transformation for PWDs. The main purpose of this paper therefore; is to show that if the varied programmes and policies relating to PWDs within the Anglophone Caribbean are to be successfully implemented, digital and traditional media will have to play a lead role through their social and ethical responsibilities in changing attitudes of non-disabled individuals towards the members of this vulnerable group. The main purpose of this paper therefore; is to show that if the varied programmes and policies relating to PWDs within the Anglophone Caribbean are to be successfully implemented, digital and traditional media will have to play a lead role through their social and ethical responsibilities in changing attitudes of non-disabled individuals towards the members of this vulnerable group. Design/methodology/approach The central argument guiding this paper is that if the varied programmes and policies relating to PWDs within the Caribbean are to be successfully implemented, the media, in all its forms, will have to play a lead role through their social and ethical responsibilities in changing attitudes of non-disabled individuals towards the members of this vulnerable group. The unequivocal questions that have been answered are how and what are the media doing to aid in the transformation of the lives of PWDs in the Caribbean? Are they fulfiling their social and ethical responsibilities? Findings The major finding is that the media in the Anglophone Caribbean has significant work to do to fulfil one of its social and ethical responsibilities in aiding the developmental transformation of PWDs in the region. Research limitations/implications The research is limited by the fact that there is serious data scarcity on the population of PWDs in the region. Serious research on the population is just emerging and this will change significantly over the next few years. Practical implications The practical implication of this study is that it will bring to the forefront of the media in the Caribbean, the importance of placing issues relating to PWDs on the development agenda in a consistent manner. Social implications PWDs will be brought in the mainstream of Caribbean society over time. Originality/value This is an original study and will undoubtedly contribute to a greater understanding of the media and PWDs in the Caribbean.

THE LINKAGE OF KAMPAR’S RUMAH LONTIOK WITH LIMAPULUH KOTO’S RUMAH GADANG

Abstrak_Dalam catatan sejarah, wilayah Kampar pernah menjadi wilayah Rantau (Hilir) dari wilayah Luhak Limapuluh Koto yang merupakan wilayah Darek (Hulu), di mana kedua wilayah ini dihubungkan oleh Sungai Kampar. Wilayah Kampar juga pernah menjadi bagian wilayah Sumatera Tengah, dan pernah dua kali berpisah; pertama oleh pemekaran yang dilakukan oleh Pemerintah Kolonial Belanda dan kedua oleh Presiden Soekarno setelah pemberontakan PRRI-Permesta dikalahkan. Bahkan kedua wilayah ini berbagi sejarah di masa klasik, terutama sejarah Kerajaan Melayu Tua, Kerajaan Sriwijaya, Kerajaan Dharmasraya, dan Kerajaan Malayupura, hingga masa Kesultanan Pagaruyung. Secara arsitektur, Rumah Lontiok di Kampar dan Rumah Gadang di Limapuluh Koto secara sekilas memiliki hubungan dan banyak kesamaan. Bagaimana keterkaitan karakteristik arsitektur antara keduanya?. Tujuan penelitian ini adalah untuk menemukan keterkaitan antara kedua rumah tradisional tersebut. Penelitian ini menggunakan metode kualitatif untuk mendapatkan hasil yang komprehensif. Hasil penelitian menunjukkan keterkaitan secara umum di antara kedua rumah tersebut, bahkan perkembangan transformasi (lineage).Kata kunci: Rumah Gadang; Rumah Lontiok; Arsitektur Vernakular; Rumah Austronesia. Abstract_ In history, Kampar Region was the Rantau (Hilir or Downstream) region of Limapuluh Koto's Darek (Hulu or Upstream), where the two regions are connected by the Kampar River. The Kampar region also once was part of the region of Central Sumatra, and was separated twice; first by the expansion carried out by the Dutch and second by Soekarno after the PRRI-Permesta rebellion was defeated. Whereas in fact, these two regions have shared history in the classical era, especially the history of the old Malay kingdoms, the Sriwijaya kingdom, the kingdom of Dhamarsraya and Malayupura, until the time of Pagaruyung. Architecturally, the Rumah Lontiok in Kampar and the Rumah Gadang in Limapuluh Koto at a glance have relationships and similarities. How is the linkage of architectural characteristics between them? The purpose of this study was to find the link between the two traditional houses. This research used a qualitative method to have a comprehensive conclusion. The results showed that both houses have a general linkage, even developmental transformation (lineage).Keywords: Rumah Gadang; Rumah Lontiok; Vernacular Architecture; Austronesian House.

Exploring public sector planning for transformational government

Purpose This paper aims to understand the conceptualisation of the notion of transformational government that is emerging within the electronic government domain. It reviewed how transformational government is manifest in the policy and strategic commitments of government departments in South Africa. The study focused on understanding the role of public sector planning towards the attainment of transformational government. Design/methodology/approach The study is interpretive and qualitative in nature. It provides the outcomes of a deductive thematic analysis conducted on strategic documents of government departments to explore their alignment and support for transformational government. Findings The paper argues for the need for public sector planning that is focused on citizen benefit realisation. The results highlight the significance of strategic plans for developmental transformation. However, the planning instruments were found to have an inconsistent orientation towards transformational government. Originality/value The study is significant in light of the implications of public policy and the associated strategic plans for citizens. This paper also contributes to research on the nascent area of transformational government.

Refraksi Yuridis Penetapan Program Legislasi Nasional di DPR RI

Prolegnas is a law developmental transformation after the amendment of UUD NRI 1945. However, the effectuation of Prolegnas’s decree by DPR RI always shows the less of law reformation level, either on qualitative measure or the quantitative. This research has a focus to arrange a law prescription of juridical refraction on the effectuation of Prolegnas’s decree by DPR RI. The research explains the peak of trouble of the effectuation of Prolegnas’s decree, consists of low level of consistency and realization, the incompatibility between Prolegnas’s substances and mandated by legislation and the list of draft bill which not based on an academic research. Those are a logical clause of two juridical refraction stages, viz, formal concession and substance concession (prospective orientation).