Usability of Video Observed Therapy with a Notification System to Improve Monitoring of Tuberculosis Treatment in Thailand (Preprint)

BACKGROUND In Thailand, the healthcare system has struggled to cope with the coronavirus disease 2019 (COVID-19), resulting in directly observed therapy (DOT) for tuberculosis (TB) being de-emphasized. Video observed therapy (VOT) or, more specifically, the Thai VOT “TH VOT” system, was then developed to replace DOT. According to the pilot study, the system needed a notification to improve usability and user compliance. The updated version of the TH VOT system thus enabled LINE notifications. OBJECTIVE This study aimed to reassess the user compliance and usability of the updated TH VOT system. METHODS This study was conducted in Hat Yai and Meuang Songkhla districts in Songkhla Province, Southern Thailand. The system was used by not only TB patients but also TB staff as observers in primary health care settings. Some of the observers used the simulated VOT system instead of the actual system due to the lack of participating patients in their jurisdiction. After 30-day usage, VOT session records were analyzed to determine the compliance of the patients and observers. The User Experience Questionnaire (UEQ) was administered to reassess the usability of the system and compare the ratings of the participants with the general benchmark scores of the UEQ. The results were summarized to reveal the user compliance and usability based on three groups: the patient, actual VOT observer, and simulated VOT observer. RESULTS Of the 19 observers, 10 were used the actual VOT, and the remaining 9 used the simulated VOT; there were also 10 TB patients. The patients, actual VOT observers, and simulated observers had about 80%, 65%, and 50% compliance, respectively, in terms of following the standard operating procedures every day. The scores of all groups on all dimensions were well above the average scores. There was no significant difference in any of the dimensional scores among the three groups. CONCLUSIONS The updated version of the TH VOT was deemed usable by both the patients and the healthcare staff. Compliance to use the system was high among the patients but moderate among the observers.

Anti-Irritant Strategy against Retinol Based on the Genetic Analysis of Korean Population: A Genetically Guided Top–Down Approach

Retinol, one of the most powerful cosmetic materials for anti-aging supported by a solid scientific background, exhibits a wide range of type and severity of irritation while showing limited user compliance. The lack of understanding of the mechanism of retinol-induced irritation has been the main hurdle in the development of anti-irritation strategies. Here, we identified 30 genetic markers related to the susceptibility to retinol-induced irritation in the Korean population. Based on the genetic analysis, a novel formula against retinol-induced irritation was developed, which mitigated the molecular pathogenesis—as indicated by the genetic markers—of the retinol-induced irritation. In human tests, this formula effectively decreased retinol-induced irritation. Furthermore, a polygenic risk score model for irritation was constructed and validated. Our comprehensive approach for the analysis of retinol-induced irritation will not only aid the development of anti-irritation strategies to ensure higher user compliance but also contribute to improving the current knowledge about the biological effects of retinoids.

A review of textile-based electrodes developed for electrostimulation

Electrical stimulation can be used for the treatment of various nerve and muscle injuries as well as acute and chronic pain conditions. An electrical pulse is applied to a muscle or nerve to activate excitable tissue using internal or external electrodes with the aim of building muscle strength, artificially creating or supporting limb movement or reducing pain. Textile electrodes offer several advantages over conventionally used disposable surface electrodes: they are flexible and re-usable and they do not require hydrogels, thereby avoiding skin irritation and allergic reactions and enhancing user comfort. This article presents a literature review that assesses the state of research on textile electrode constructions. Based on the review, production approaches and designs are compared, methods for evaluating stimulation discomfort and pain are proposed and issues related to user compliance are discussed. The article concludes with suggestions for future work focused on investigating the impacts of textile-based electrode parameters on comfort, convenience and ease of use.

Schedule-Constrained Demand Management in Two-Region Urban Networks

Demand management aiming to optimize system cost while ensuring user compliance in an urban traffic network is a challenging task. This paper introduces a cooperative demand redistribution strategy to optimize network performance through the retiming of departure times within a limited time window. The proposed model minimizes the total time spent in a two-region urban network by incurring minimal disruption to travelers’ departure schedules. Two traffic models based on the macroscopic fundamental diagram (MFD) are jointly implemented to redistribute demand and analyze travelers’ reaction. First, we establish equilibrium conditions via a day-to-day assignment process, which allows travelers to find their preferred departure times. The trip-based MFD model that incorporates individual traveler attributes is implemented in the day-to-day assignment, and it is conjugated with a network-level detour ratio model to incorporate the effect of congestion in individual traveler route choice. This allows us to consider travelers with individual preferences on departure times influenced by desired arrival times, trip lengths, and earliness and lateness costs. Second, we develop a nonlinear optimization problem to minimize the total time spent considering both observed and unobserved demand—that is, travelers opting in and out of the demand management platform. The accumulation-based MFD model that builds on aggregated system representation is implemented as part of the constraints in the nonlinear optimization problem. The results confirm the resourcefulness of the model to address complex two-region traffic dynamics and to increase overall performance by reaching a constrained system optimum scenario while ensuring the applicability at both full and partial user compliance conditions.

The Effect of Tenacity on the Improvement of Children's Serious Game-Play Ability: A Retrospective Study (Preprint)

BACKGROUND Through several recent studies, tenacity, which involves solving problems with patience and enthusiasm for the goal, has emerged as an indicator of education effect, therapeutic effect, and well-being. However, relatively little research has assessed how to measure and evaluate tenacity. OBJECTIVE We aimed to analyze the usage pattern of the serious game to define tenacity and examine how it affects the effectiveness of cognitive development by measuring the difference between game-driven cognitive index based on detailed cognitive activities and game score. METHODS We used a serious game for 5419 children who responded to the survey from September 20, 2018, to July 14, 2020, divided into six groups according to their tenacity level and presence of developmental disabilities. We defined user tenacity through game usage patterns and analyzed how children play the serious game differently according to their characteristics. RESULTS We confirmed that tenacity affects the distribution of score changes from the primary episode to the 10th episode of serious games, showing statistical significance for some of the sub-categories in both the typical developments group and developmental disabilities group. Moreover, we found differences in difference estimation and found that tenacity affects the improvement of a serious game-driven cognitive index for Inference, Numerical and Organizing categories commonly seen in both typical developments group (p=<.000, p=0.001, p=.001), and developmental disabilities group (p=.0019, p=.022, p=.002). CONCLUSIONS Based on these findings, we propose that cognitive improvement is derived from not only natural-wise content-driven effects but also user compliance effects depending on the non-cognitive factors, regardless of the presence of developmental disabilities.

The Nagoya Protocol and Its Implications on the EU Atlantic Area Countries

The Nagoya Protocol on Access to Genetic Resources and Fair and Equitable Sharing of Benefits Arising from their Utilization came into force in October 2014. In the European Union (EU), new legislation had to be developed in order to apply the mandatory elements of the Protocol, namely, the Regulation (EU) Nº 511/2014 (ABS Regulation) and the Implementing Regulation (EU) 2015/1866, laying down detailed rules for the implementation of Regulation ABS with regard to the register of collection, monitor user compliance, and best practices. As a consequence, EU countries had to develop their own legislation in order to implement the Nagoya Protocol (NP), as well as the EU regulations. One important fact that distinguishes the national legislation of the EU countries is that some countries choose to control access to genetic resources (GR), while others do not apply access measures. The Atlantic Area countries in the EU share an attractive coastline with regard to the potential of their GR. In addition, the microalgae industry has been identified as a business sector with high potential. Therefore, it is important for GR users to be informed about the existing regulations and the national differences that may occur within EU countries. In this article, the origins and main content of the Nagoya Protocol are described, together with their implications at the EU level and particularly in the countries of the Atlantic Area region. As a result, a decision framework is proposed in order to support the GR users among this region.

Pengaruh Penerapan E-Filling Terhadap Kepatuhan Wajib Pajak Orang Pribadi

The development of increasingly sophisticated technology now makes it easier for humans to do various jobs. The purpose of this study was to determine the level of individual taxpayer compliance that was influenced by the application of e-filling at KPP Pratama Gianyar. The method of data analysis uses path analysis. The research data uses primary data, namely the answers of individual taxpayers registered at KPP Pratama Gianyar for the questionnaire given. The results of this study indicate that business expectations and knowledge possessed by users have a positive influence on user compliance. Security and confidentiality of data, the speed of reporting has a positive influence on interest in using e-filling. Keywords : E-Filling, compliance, knowledge, security, confidentiality.