Lipid engineered nanoparticle therapy for burn wound treatment

Introduction: Skin is the largest organ of the human body protecting the underlying organs and tissues from any foreign attack. Any damage caused in the skin may sometimes result in serious consequences within the internal body tissues. Burn is one such issue that damage the layers of skin and thereby makingthe skin vulnerableand pronefor any foreign matter to enter and cause serious diseases. Methods: An online literature assessment was steered for the lipid nanoparticles, burn wound treatments, and different types of nanoformulation. Appropriate information was taken from different electronic scientific databases such as Web of Science, Elsevier, Science Direct, Springer, PubMed, Google Scholar etc.,Additional data was summarized from textbooks, local prints and scripts. Results: Recent innovations and developments in nanotechnology-based drug delivery systems has shown promising results in minimizing the drawbacks associated with conventional therapies. Lipid based nanoparticles possess capabilities to deliver active agents to their target site without the possibility of degradation. Conventional therapy of burn wound is costly and the treatment is long lasting, making the patient uncomfortable. Moreover, italso doesn’t yield satisfactory results or narrow effects.Encapsulation of bioactives inside the lipid core protects the active entity from pH and enzymatic degradations. Conclusion: This review highlights the drawbacks associated with the conventional dosage forms. A lot of consideration is focused on the advancement of nanomaterials using innovative methods in wound care for treating burn wounds with the faster healing effect.This review article highlights recent developments in lipid based nanoformulations for treatment of burn wound injury.

Fenofibrate Niosomes by Modified Ether Injection Method- of Proper Diet to Help Lower “Bad

The quest never ends. From the very beginning of the human race the quest is going on for newer and better alternatives and in case of drugs it will continue till we find a drug with maximum efficacy and no side effects. Many drugs, particularly chemotherapeutic agents, have narrow therapeutic window and their clinical uses are limited and compromised by dose limiting toxic effect. Thus, the therapeutic effectiveness of the existing drugs is improved by formulating them in an advantageous way. In the past few decades, considerable attention has been focused on the development of new drug delivery system (NDDS). The NDDS should ideally full fill two prerequisites. Firstly, it should deliver the drug at a rate directed by the needs of the body, over the period of treatment. Secondly, it should channel the active entity to the site of action. Conventional dosage forms including prolonged release dosage forms are unable to meet none of these. At present, no available drug delivery system behaves ideally, but sincere attempts have been made to achieve them through various novel approaches in drug delivery1. Approaches are being adapted to achieve this goal, by paying considerable attention either to control the distribution of drug by incorporating it in a carrier system, or by altering the structure of the drug at the molecular level, or to control the input of the drug into the bio environment to ensure an appropriate profile of distribution.

Fertilization

The story of fertilization is often told as man’s story, a race ending in capturing and penetrating an egg. Science finds these stories to be false myths. The female reproductive tract is not a raceway, but an active entity that gives sperm the ability to activate the egg; and the merging of sperm and egg is not done by boring or drilling through the egg, but by the melting of cell membranes so that the two cells become one.

Constructing the “self” and the “other” in Bush’s political discourse before and after the Iraq war (2002–2008)

The article investigates the construction of the “self” and the “other” in George W. Bush’s political discourse before and after the Iraq war. Van Dijk’s ideological square theory is used to examine the group polarization of Us versus Them dichotomy. Halliday’s systemic functional grammar is utilised to analyse the speeches and to designate the strategies that Bush utilises to differentiate between the protagonist (America) and the antagonist (Iraq). Furthermore, the diachrony in Bush’s discourse regarding Iraq’s WMDs and Saddam Hussein is also examined. The results of the study indicated that before the invasion, Iraq was an active entity in upgrading its WMDs’ program and supporting terrorism. However, after the invasion, Iraq is now perceived as a beacon of hope in the Middle East, thus, justifying America’s illegitimate act of invading Iraq.

PRIESTLY DYNAMIC HOLINESS AND DEUTERONOMIC STATIC HOLINESS

There are several diverences between the laws of cult and the pre-supposition regarding ritual and impurity in the Priestly Schools and the book of Deuteronomy. Both sources regard the relationship between the priest and the laity and the access to the sacred in diverent ways. The fundamental reason that lies at the base of these diverent cultic systems is distinct perceptions of holiness. The diverence is not in the concept of what is holy and what is profane, but rather in the understanding of what holiness really is. The Priestly Schools view holiness as dynamic, sensitive and dangerous, and maintain that the access to the sacred should be limited. In contrast, in Deuteronomy holiness is static, and the access to the sacred is far less restricted, since it is not dangerous or threatening. In other words, in Deuteronomy holiness is not an active entity but a status. These opposing world-views regarding the holy are actually related to general conceptions about the character of the relationship between humans and nature on the one hand, and between man and God on the other hand.