Muon detection at FCC-ee

Muons provide a clean experimental signature, typically traversing the whole experimental apparatus without decaying. Muon detection systems are therefore usually located at a rather large distance from the primary interaction vertex after all other sub-detectors. As such, experimental apparatuses at FCC-ee will certainly employ very large muon systems, covering areas of a few thousand square meters. For obvious reasons of cost, the most suitable detectors to realise these large muon systems are gas detectors. In particular, in recent years, micro-pattern gas detectors (MPGDs) have undergone very interesting developments, providing several new types of detectors with very good spatial and time resolution, high efficiency, high rate capability and high radiation tolerance. The good position and time resolution makes a MPGD an excellent particle tracker, reconstructing tracks at 4–5 m from the primary interaction vertex with sub-mm precision. Therefore MPGDs, apart from efficiently detecting muons, can precisely track and help identifying also hypothesized long lived particles (LLP) that would decay outside of the central trackers. MPGDs have the distinct advantage of being, at least for some detectors and some parts of them, mass-producible by industry, since they employ materials and manufacturing procedures that are used extensively for printed circuit boards (PCB) production. A particularly innovative MPGD, the $$\mu $$ μ RWELL, is considered as a possible candidate to build the large muon system of the IDEA detector concept for FCC-ee and is described in some more detail. Other technologies that could be considered for the realisation of muon detection systems are also briefly discussed.

The 23S Ribosomal RNA From Pyrococcus furiosus Is Circularly Permuted

Synthesis and assembly of ribosomal components are fundamental cellular processes and generally well-conserved within the main groups of organisms. Yet, provocative variations to the general schemes exist. We have discovered an unusual processing pathway of pre-rRNA in extreme thermophilic archaea exemplified by Pyrococcus furiosus. The large subunit (LSU) rRNA is produced as a circularly permuted form through circularization followed by excision of Helix 98. As a consequence, the terminal domain VII that comprise the binding site for the signal recognition particle is appended to the 5´ end of the LSU rRNA that instead terminates in Domain VI carrying the Sarcin-Ricin Loop, the primary interaction site with the translational GTPases. To our knowledge, this is the first example of a true post-transcriptional circular permutation of a main functional molecule and the first example of rRNA fragmentation in archaea.

Cosmic-Ray Extremely Distributed Observatory

The Cosmic-Ray Extremely Distributed Observatory (CREDO) is a newly formed, global collaboration dedicated to observing and studying cosmic rays (CR) and cosmic-ray ensembles (CRE): groups of at least two CR with a common primary interaction vertex or the same parent particle. The CREDO program embraces testing known CR and CRE scenarios, and preparing to observe unexpected physics, it is also suitable for multi-messenger and multi-mission applications. Perfectly matched to CREDO capabilities, CRE could be formed both within classical models (e.g., as products of photon–photon interactions), and exotic scenarios (e.g., as results of decay of Super-Heavy Dark Matter particles). Their fronts might be significantly extended in space and time, and they might include cosmic rays of energies spanning the whole cosmic-ray energy spectrum, with a footprint composed of at least two extensive air showers with correlated arrival directions and arrival times. As the CRE are predominantly expected to be spread over large areas and, due to the expected wide energy range of the contributing particles, such a CRE detection might only be feasible when using all available cosmic-ray infrastructure collectively, i.e., as a globally extended network of detectors. Thus, with this review article, the CREDO Collaboration invites the astroparticle physics community to actively join or to contribute to the research dedicated to CRE and, in particular, to pool together cosmic-ray data to support specific CRE detection strategies.

Reactions Catalyzed by 2-Halogenated Azolium Salts: From Halogen-Bond Donors to Brønsted-Acidic Salts

Our research group has developed a variety of organocatalysts, especially bi- and multi-functional hydrogen-bond (HB)-donor catalysts. Since 2013, we have become interested in halogen-bond (XB) interactions in organic synthesis, and we have focused on the development of organocatalysts using XBs. Although it is difficult to develop otherwise inaccessible transformations using XBs as the primary interaction, we found several unique reactions that use XB interactions in combination with co-catalysts such as trimethylsilyl iodide, Proton Sponge, and Schreiner’s thiourea. During the synthesis of various 2-iodoazolium salts that can serve as XB donors, a ‘protonated’ 2-iodoazolium salt (a Brønsted-acidic salt) was unexpectedly obtained instead of the corresponding ‘alkylated’ 2-iodoazolium salt (XB donor). The obtained Brønsted-acidic salt is unprecedentedly effective for the N-glycosylation of amides. This account summarizes our findings in this area to date.1 Introduction2 Organoiodine-Compound-Mediated Semipinacol Rearrangement via C–X Bond Cleavage3 2-Iodoazolium-Salt-Catalyzed Reactions through Halogen Bonding (XB)3.1 TMSI-Co-catalyzed Dehydroxylative Coupling of Alcohols with ­Organosilanes3.2 Base-Co-catalyzed Umpolung Alkylation of Oxindoles with an ­Iodonium(III) Ylide3.3 Thiourea-Co-catalyzed N-Glycofunctionalization of Amides3.4 Thiourea-Co-catalyzed N-α-Glycosylation of Amides4 Catalytic Reactions Using 2-Haloazolium Salts as the Brønsted Acids4.1 N-β-Glycosylation of Amides4.2 N-β-2-Deoxyglycosylation of Amides5 Conclusions

Constituent quarks and systematic errors in mid-rapidity charged multiplicity dNch/dη distributions

Centrality definition in A + A collisions at colliders such as RHIC and LHC suffers from a correlated systematic uncertainty caused by the efficiency of detecting a p + p collision ([Formula: see text] for PHENIX at RHIC). In A + A collisions where centrality is measured by the number of nucleon collisions, [Formula: see text], or the number of nucleon participants, [Formula: see text], or the number of constituent quark participants, [Formula: see text], the error in the efficiency of the primary interaction trigger (Beam–Beam Counters) for a p + p collision leads to a correlated systematic uncertainty in [Formula: see text], [Formula: see text] or [Formula: see text] which reduces binomially as the A + A collisions become more central. If this is not correctly accounted for in projections of A + A to p + p collisions, then mistaken conclusions can result. A recent example is presented in whether the mid-rapidity charged multiplicity per constituent quark participant [Formula: see text] in Au + Au at RHIC was the same as the value in p + p collisions.

Mobile Governance for Affordability and Profitability/Feasibility

The chapter expresses the extent of the application of “e” and mobile mode for governance along with the extent to which, this application can be uplifted through building up the case around the healthcare system and changing market scenario in rural areas because of the researches which the authors/proponents of this chapter have been conducting. The premise that emerges in the chapter has evolved through the primary interaction with the concerned population. The findings suggest that the rural people of India opine and desire for better healthcare services and market scenario through alternative means, they are willing to pay for the services, they have opined positively and they wish to be involved in the market development scenario wherein E-governance and m-governance has emerged to be an important mode.

Understanding “It Depends” in Organizational Research

The study of interaction effects is critical for creating, extending, and bounding theory in organizational research. Integrating and extending prior work, we present a taxonomy of two-way interaction effects that can guide organizational scholars toward clearer, more precise ways of developing theory, advancing hypotheses, and interpreting results. Specifically, we identify three primary interaction types, including strengthening, weakening, and reversing effects. In addition, we explore subcategories within these interaction types. Our review of articles published in leading management and applied psychology journals from 2009 to 2013 supports the generalizability of this framework. We offer specific recommendations for using this taxonomy to deliver more precise development, testing, and interpretation of interaction hypotheses.

Revisiting secondary interactions in neighboring group participation, exemplified by reactivity changes of iminylium intermediates

In addition to the primary interaction with the nearest neighboring group, secondary interactions involving another neighboring group can also occur in principle, changing the reaction pathway.