PTPN2 Expression in Cystadenocarcinoma Ovary and It’s Clinical Value Based on TCGA Database

Ovarian serous cystadenocarcinoma (OV) is a malignant tumor that often has a poor prognosis because of its late detection. The expression of PTPN2 is associated with a variety of tumors, but its effect on OV is not well understood. Therefore, we analyzed the relationship between PTPN2 and the prognosis of OV. Analysis of patients with OV using The Cancer Genome Atlas revealed an association between PTPN2 expression and the prognosis of OV. We established a model of the relationship between these factors by logistic regression, which showed a significant correlation between the tumor grade and decreased expression of PTPN2. Kaplan-Meier survival analysis showed that low PTPN2 expression was associated with poor overall survival. Further analysis of the expression of immune cells in OV using the ssGSEA package revealed a significant correlation between the expression level of PTPN2 in OV and the numbers of mast, gamma delta, helper, and central memory T cells. We also found differences between the phenotypic pathways associated with low PTPN2 expression and pathways of genes and proteins that determine epithelial-mesenchymal transformation. Finally, a network diagram of protein molecular interactions was drawn using the STRING database, which showed that PTPN2 was closely related to the signal converter and transcriptional activator family and Janus kinase family. Thus, PTPN2 shows potential for use as a prognostic biomarker in OV and is associated with immune infiltration.

SIMULATION OF AN ELECTROMYOGRAPHIC SIGNAL CONVERTER FOR ADAPTIVE ELECTRICAL STIMULATION TASKS

The subject matter of the article is an electromyographic signal transducer, which are an integral part of devices for adaptive electrical stimulation of muscle structures based on reverse electromyographic communication. The goal of the work is to study the features, obtaining the corresponding theoretical relationships and computer modeling of a differential biopotential converter, providing amplification of the useful component and suppression of harmful interference, the spectra of which intersect. The following tasks were solved in the article: determining the effect of electrode width and electrode spacing on crosstalk; formation of the electrode-skin model and the input circuit of the transducer, obtaining theoretical relations for calculating the rejection coefficient, construction of the transducer circuit and its computer simulation. The following methods were used – methods of mathematical modeling of processes and technical devices; methods of analysis, structural and parametric synthesis of nonlinear electronic circuits; methods of machine design. The following results were obtained – a biopotential amplifier circuit with tracking feedback on power supply is proposed; modeling of dynamic processes by means of the Multisim program was carried out; on the basis of the constructed model of the electrode-skin input circuit and the obtained analytical relationships, the rejection coefficient of the input circuit of the equivalent circuit is calculated; the requirements for the signal registration module are formulated. Conclusions: The considered version of the electromyographic signal converter circuit based on tracking communication on power supply, effectively rejects 50 Hz common mode noise. On the basis of the constructed equivalent model of the input circuit of the amplifier, the theoretical relation for calculating the rejection coefficient of such amplifiers. The circuit is simulated in the Multisim program, the results confirmed the correctness of its functioning. The requirements for the interelectrode distance and the thickness of the electrodes themselves are also formulated. The results obtained can be used to design complexes for adaptive electrical stimulation.

PTPN2 Expression in Cystadenocarcinoma Ovary and It’s Clinical Value Based on TCGA Database

Ovarian serous cystadenocarcinoma (OV) is a malignant tumor that often has a poor prognosis because of its late detection. The expression of PTPN2 is associated with a variety of tumors, but its effect on OV is not well understood. Therefore, we analyzed the relationship between PTPN2 and the prognosis of OV. Analysis of patients with OV using The Cancer Genome Atlas revealed an association between PTPN2 expression and the prognosis of OV. We established a model of the relationship between these factors by logistic regression, which showed a significant correlation between the tumor grade and decreased expression of PTPN2. Kaplan-Meier survival analysis showed that low PTPN2 expression was associated with poor overall survival. Further analysis of the expression of immune cells in OV using the ssGSEA package revealed a significant correlation between the expression level of PTPN2 in OV and the numbers of mast, gamma delta, helper, and central memory T cells. We also found differences between the phenotypic pathways associated with low PTPN2 expression and pathways of genes and proteins that determine epithelial-mesenchymal transformation. Finally, a network diagram of protein molecular interactions was drawn using the STRING database, which showed that PTPN2 was closely related to the signal converter and transcriptional activator family and Janus kinase family. Thus, PTPN2 shows potential for use as a prognostic biomarker in OV and is associated with immune infiltration.

Information Systems of Support of Pedagogical Control in the Physical Education of Students

The study is to substantiate and implement modern electronic automated monitoring systems to improve the testing of speed-strength abilities in the process of physical education. Materials and methods. To solve the research tasks used the methods of comparing and contrasting are used and analysis, synthesis, abstraction, formalization and technical modeling. Results. The developed capacitive sensor device for speed control is presented. The device is built on a combination of modern nanotechnology and microprocessor systems. As part of the device, the array of active electrodes with digital output registers an input signal from a marker placed on the monitoring object and whose position changes during the exercise. Then the digital signal through the interface and the communication line, goes to the signal converter, where it is processed and wireless transmission devices signal goes to the personal computer, where the result of the exercise is displayed. Conclusions. Use in pedagogical control of the physical education process of the developed device provides a reliable objective test data with little loss of time to ensure the quality of control.

Potential of New Technologies in Providing Efficiency of Pedagogical Control in Physical Education

The study objective is to substantiate and implement modern electronic automated monitoring systems to improve the testing of speed-strength abilities in the process of physical education. Materials and methods. To solve the research tasks used the methods of comparing and contrasting are used and analysis, synthesis, abstraction, formalization and technical modeling. Results. The developed capacitive sensor device for control of speed-power abilities is presented. The device is built on a combination of modern nanotechnology and microprocessor systems. As part of the device, the array of active electrodes with digital output registers an input signal from a marker placed on the monitoring object and whose position changes during the exercise. Then the digital signal through the interface and the communication line, goes to the signal converter, where it is processed and wireless transmission devices signal goes to the personal computer, where the result of the exercise is displayed. Conclusions. Use in pedagogical control of the physical education process of the developed device provides reliable objective test data with little loss of time to ensure the quality of control.

A Fast Transient Response Digital LDO with a TDC-Based Signal Converter

The digital low drop-out regulator (LDO) has been used widely in digital circuits for its low supply voltage characteristics. However, as the traditional digital LDOs regulate the output voltage code at a rate of 1 bit per clock cycle, the transient response speed is limited. This paper presents a digital LDO to improve transient response speed with a multi-bit conversion technique. The proposed technology uses a voltage sensor and a time-to-digital converter to convert the output voltage to digital codes. Based on a 65-nm CMOS process, the proposed DLDO reduces the settling time from 147.8 ns to 25.2 ns on average and the response speed is improved by about six times.

Programmable mismatch-fueled high-efficiency DNA signal converter

Herein, by directly introducing mismatched reactant DNA, high-reactivity and high-threshold enzyme-free target recycling amplification (EFTRA) is explored.