The design of advanced miniaturized ultra-low power interfaces for sensors is extremely important for energy-constrained monitoring applications, such as wearable, ingestible and implantable devices used in the health and medical field. Capacitive sensors, together with their correspondent digital-output readout interfaces, make no exception. Here, we analyse and design a capacitance-to-digital converter, based on the recently introduced iterative delay-chain discharge architecture, showing the circuit inner operating principles and the correspondent design trade-offs. A complete design case, implemented in a commercial 180 nm CMOS process, operating at 0.9 V supply for a 0–250 pF input capacitance range, is presented. The circuit, tested by means of detailed electrical simulations, shows ultra-low energy consumption (≤1.884 nJ/conversion), excellent linearity (linearity error 15.26 ppm), good robustness against process and temperature corners (conversion gain sensitivity to process corners variation of 114.0 ppm and maximum temperature sensitivity of 81.9 ppm/∘C in the −40 ∘C, +125 ∘C interval) and medium-low resolution of 10.3 effective number of bits, while using only 0.0192 mm2 of silicon area and employing 2.93 ms for a single conversion.