Looking for Razors and Needles in a Haystack: Multifaceted Analysis of Suicidal Declarations on Social Media—A Pragmalinguistic Approach

In this paper, we study language used by suicidal users on Reddit social media platform. To do that, we firstly collect a large-scale dataset of Reddit posts and annotate it with highly trained and expert annotators under a rigorous annotation scheme. Next, we perform a multifaceted analysis of the dataset, including: (1) the analysis of user activity before and after posting a suicidal message, and (2) a pragmalinguistic study on the vocabulary used by suicidal users. In the second part of the analysis, we apply LIWC, a dictionary-based toolset widely used in psychology and linguistic research, which provides a wide range of linguistic category annotations on text. However, since raw LIWC scores are not sufficiently reliable, or informative, we propose a procedure to decrease the possibility of unreliable and misleading LIWC scores leading to misleading conclusions by analyzing not each category separately, but in pairs with other categories. The analysis of the results supported the validity of the proposed approach by revealing a number of valuable information on the vocabulary used by suicidal users and helped to pin-point false predictors. For example, we were able to specify that death-related words, typically associated with suicidal posts in the majority of the literature, become false predictors, when they co-occur with apostrophes, even in high-risk subreddits. On the other hand, the category-pair based disambiguation helped to specify that death becomes a predictor only when co-occurring with future-focused language, informal language, discrepancy, or 1st person pronouns. The promising applicability of the approach was additionally analyzed for its limitations, where we found out that although LIWC is a useful and easily applicable tool, the lack of any contextual processing makes it unsuitable for application in psychological and linguistic studies. We conclude that disadvantages of LIWC can be easily overcome by creating a number of high-performance AI-based classifiers trained for annotation of similar categories as LIWC, which we plan to pursue in future work.

Processing of slow-global auditory regularities causes larger neural responses to heartbeats in patients under minimal consciousness state, compared to unresponsive wakefulness syndrome

Objectives: Determine if contextual processing of auditory regularities (local-global paradigm) modulate the heartbeat-evoked responses (HERs), and if these modulations may provide complementary information to the auditory related potentials to facilitate the diagnose of patients with disorders of consciousness (DOC). Methods: DOC patients underwent the local-global paradigm to evaluate the cognitive processing of short/long term-auditory regularities. High-density EEG was recorded to evaluate HERs in local, global and overall conditions. Results: The global effect triggers higher HERs, as well as overall higher HER variance appears in minimally conscious patients. The variance and amplitude effects were uncorrelated, indicating different cognitive processes. Discussion: Our results corroborate previous findings on HER variance, a marker able to separate DOC without specific stimulations. HER modulations in response to global auditory irregularities represents a novel neural signature of consciousness access, which may facilitate the bedside diagnosis of state of consciousness with more affordable options to neuroimaging methods.

Impaired Adaptation and Laminar Processing of the Oddball Paradigm in the Primary Visual Cortex of Fmr1 KO Mouse

Both adaptation and novelty detection are an integral part of sensory processing. Recent animal oddball studies have advanced our understanding of circuitry underlying contextual processing in early sensory areas. However, it is unclear how adaptation and mismatch (MM) responses depend on the tuning properties of neurons and their laminar position. Furthermore, given that reduced habituation and sensory overload are among the hallmarks of altered sensory perception in autism, we investigated how oddball processing might be altered in a mouse model of fragile X syndrome (FX). Using silicon probe recordings and a novel spatial frequency (SF) oddball paradigm, we discovered that FX mice show reduced adaptation and enhanced MM responses compared to control animals. Specifically, we found that adaptation is primarily restricted to neurons with preferred oddball SF in FX compared to WT mice. Mismatch responses, on the other hand, are enriched in the superficial layers of WT animals but are present throughout lamina in FX animals. Last, we observed altered neural dynamics in FX mice in response to stimulus omissions. Taken together, we demonstrated that reduced feature adaptation coexists with impaired laminar processing of oddball responses, which might contribute to altered sensory perception in FX syndrome and autism.

Social buffering in horses is influenced by context but not by the familiarity and habituation of a companion

Social buffering occurs when the presence of one animal attenuates another’s stress response during a stressful event and/or helps the subject to recover more quickly after a stressful event. Inconsistent previous results might reflect previously unrecognised contextual influences, such as the nature of the stimulus presented or social factors. We addressed these issues in a two-part study of horses paired with familiar (16 subjects) or unfamiliar (16 subjects) companions. Each subject performed 4 tests in a counterbalanced order: novel object test (static ball)—alone or with companion; and umbrella opening test—alone or with companion. Social buffering was significantly influenced by the nature of the stimulus presented, but not by companion’s habituation status or familiarity. Importantly, the stimulus used produced differential effects on behavioural and physiological measures of buffering. A companion significantly reduced behavioural response (reactivity) in the novel object test but not in the umbrella test. However, heart rate recovered more quickly for subjects with a companion in the umbrella test but not in the novel object test. We propose that circumstances which permit greater contextual processing may facilitate demonstration of behavioural effects of social buffering, whereas buffering in response to startling events may be manifest only during post-event physiological recovery.

Emulating Cued Recall of Abstract Concepts via Regulated Activation Networks

concepts play a vital role in decision-making or recall operations because the associations among them are essential for contextual processing. Abstract concepts are complex and difficult to represent (conceptually, formally, or computationally), leading to difficulties in their comprehension and recall. This contribution reports the computational simulation of the cued recall of abstract concepts by exploiting their learned associations. The cued recall operation is realized via a novel geometric back-propagation algorithm that emulates the recall of abstract concepts learned through regulated activation network (RAN) modeling. During recall operation, another algorithm uniquely regulates the activation of concepts (nodes) by injecting excitatory, neutral, and inhibitory signals to other concepts of the same level. A Toy-data problem is considered to illustrate the RAN modeling and recall procedure. The results display how regulation enables contextual awareness among abstract nodes during the recall process. The MNIST dataset is used to show how recall operations retrieve intuitive and non-intuitive blends of abstract nodes. We show that every recall process converges to an optimal image. With more cues, better images are recalled, and every intermediate image obtained during the recall iterations corresponds to the varying cognitive states of the recognition procedure.

Social buffering in horses (Equus caballus): Influence of context, companion familiarity and companion habituation

Social buffering occurs when the presence of one animal attenuates another’s stress response during a stressful event and/or helps the subject to recover more quickly after a stressful event. Inconsistent previous results might reflect previously unrecognised contextual influences, such as the nature of the stimulus presented or social factors. We addressed these issues in a two-part study of horses paired with familiar (16 subjects) or unfamiliar (16 subjects) companions. Each subject performed 4 tests in a counterbalanced order: novel object test (static ball) – alone or with companion; and umbrella opening test – alone or with companion. Social buffering was significantly influenced by the nature of the stimulus presented, but not by companion’s habituation status or familiarity. Importantly, the stimulus used produced differential effects on behavioural and physiological measures of buffering. A companion significantly reduced behavioural response (reactivity) in the novel object test but not in the umbrella test. However, heart rate recovered more quickly for subjects with a companion in the umbrella test but not in the novel object test. We propose that circumstances which permit greater contextual processing may facilitate demonstration of behavioural effects of social buffering, whereas buffering in response to startling events may be manifest only during post-event physiological recovery.

Ventral hippocampus mediates the context-dependence of two-way signaled avoidance in male rats

Considerable work indicates that instrumental responding is context-dependent, but the neural mechanisms underlying this phenomenon are poorly understood. Given the important role for the hippocampal formation in contextual processing, we hypothesized that reversible inactivation of the hippocampus would impair the context-dependence of active avoidance. To test this hypothesis, we used a two-way signaled active avoidance (SAA) task that requires rats to shuttle across a divided chamber during a tone CS in order to avoid a footshock US. After training, avoidance responding was assessed in an extinction test in both the training context and a novel context in a counterbalanced order. Rats performed significantly more avoidance responses in the training context than in the novel context, demonstrating the context-dependence of shuttle avoidance behavior. To examine the role of the hippocampus in the context-dependence of SAA, we reversibly inactivated either the dorsal (DH) or ventral hippocampus (VH) prior to testing. Inactivation of the VH eliminated the context-dependence of SAA and elevated avoidance responding in the novel context to levels similar to that expressed in the training context. In contrast, DH inactivation had no effect on avoidance in either context, and neither manipulation affected freezing behavior. Therefore, the integrity of the VH, but not DH, is required for the expression context-dependence of avoidance behavior.