In a host of areas national regulators play only a limited role in dealing with issues, risks, and problems. Issues have to be dealt with in complex networks comprising not only regulators at different levels of government but also non-state bodies. When regulation is conducted by means of such complex networks, special challenges arise in discharging the key tasks of setting objectives, delivering outcomes, and satisfying representative values. This chapter focuses on transnational regimes, which tend to involve more complex networks than domestic systems. However, even when risks and problems are more distinctly located within national boundaries, many of the challenges are echoed when national regulators operate within control regimes that are polycentric and involve networks of bodies that are located at different levels of government (local, regional, national, and supra-national), that have different characteristics (public, private, state, non-state) and exert different kinds of influence (binding, non-binding). The challenges and advantages of ‘networked’ regulation are discussed.