In this chapter, the spacecraft charging effects that lead to ESD events, as well as the associated immunity testing required, are presented in detail and compared to the human-induced discharges, mainly simulated by most commercial ESD generators. Additionally, design guidelines for mitigating the effects of these ESD occurrences, essential for every space application designer, are discussed. Finally, the measurement requirements, as well as the test setups, regarding the immunity testing to power leads transients are described thoroughly. This chapter aims at reviewing the current international standards and the recent bibliography, summarizing and commenting on the EMC requirements, regarding the transient phenomena, pinpointing the differentiations of these standards and their effects on the design procedure and testing creditability.