Digitalization is the use of technological innovations within the business context with a major influence on products, services, business processes, sales channels, and supply channels. The associated potential advantages include, among others, increased sales or productivity, innovations in price creation, and new sorts of client interaction. Global enterprises are facing supply chain issues, and consequently, potentially higher operational costs, lower inventory, and the prospects of lower demand will make them reluctant to disburse resources and time to connect in M&A and financing activities, predominantly if valuations of targets remain high. Digitalization of the supply chain (DSC) could be a way that companies can start to strategize and accomplish trade strength against supply chain disturbance. The main focus of this chapter is that digitalization enhances prosperity without human contact in a pandemic, will alter labor markets, and impacts business models.