In this study, the effect of school leadership on student achievement is examined based on the PISA 2015 data in the Turkish context, conducting a multilevel analysis. According to the results of the study, gender, economic, social, cultural status of the family, and grade repetition, school type, and the interaction of school type and grade repetition are directly associated with the students' science achievement, whereas leadership skills of school principals are not related. Several reasons for such an insignificant relationship between leadership skills and student achievement are discussed. The effect of culture on leadership orientations of different countries constitute the center of this discussion. In this regard, for Turkey and countries alike, where the self-protective leadership orientation is highly valued, instructional and professional development leadership skills of principals are recommended, considering schools are the professional learning communities to increase the contribution of principals' leadership skills on student outcomes.