In today’s increasingly diverse world, patients will inevitably interact with physicians who are of very different racial, ethnic, religious, and/or geographical backgrounds from themselves. When a patient requests a physician of another race, religion, or gender, or one who speaks another language, the physician must take many factors into consideration when determining whether to accede to the request. These considerations include historical factors (e.g., bigotry vs. the potential benefits of race concordance), ethical considerations (e.g., autonomy, justice), patient factors (e.g., the patient’s decision-making capacity), and organizational factors (e.g., policies and procedures to respect both patients and providers). This chapter presents a general framework to help psychiatrists to make these sometimes difficult decisions. Case vignettes are provided and analyzed throughout the chapter.