There is no way to acquire, store, and disseminate knowledge other than semiotically. Yet semiotics is hardly acknowledged in science, and not at all as science. Were it not for the fame of a few writers (Barthes, Derrida, and especially Eco), associated more with the semiotics of culture, few would even know that such a knowledge domain exists. In the age of computers, genetics, and networks—all of underlying semiotic condition—semiotics would at best qualify as pertinent to an obscure past, but insignificant for current endeavors. Gnoseologically, there is little to gain from acknowledging the shortcomings of semiotics. Epistemologically, quite a bit is at stake in grounding semiotics among the fundamental sciences. For this to come about, new interrogations become necessary: Why knowledge? What is knowledge? What kind of knowledge? How is knowledge acquired? One way or another, the answer will acknowledge semiotic processes as a necessary factor. The perspective advanced in this chapter relies on an understanding of the living, and, in particular, of the human being, that ascertains anticipation as definitory. The future is made part of the present via semiotic processes. This is significant because in the age of neurons, suggestive of brain activity and of attempts to emulate it, to distinguish between knowledge supporting human activity, embodied in new technologies, and knowledge essential to the unfolding of the living becomes very difficult.