Fasting Glucose Levels and Incident Diabetes Mellitus in Older Nondiabetic Adults Randomized to Receive 3 Different Classes of Antihypertensive Treatment

Objective: To see the frequency of diabetes mellitus and impaired fasting glucose levels in hypertensive patients. Design:Descriptive study. Place of Study: OPD / Filter clinic. Pakistan Institute of Medical Sciences. Islamabad. Patients and Methods: Thisstudy was carried out on 116 hypertensive patients during the period from August to September '2008. Out of 116 patients, 64 werefemales and 52 were males with age group between 20 to 70 years. Secondary causes are ruled out on the basis of history and physicalexamination. Blood samples were sent to PIMS laboratory for fasting glucose. Data and results were analyzed in SPSS. Results:According to this study, out of 116 patients, there were18 patients who had diabetes mellitus while 33 had hypertension with impairedfasting glucose tolerance which is statistically significant. The females as compared to males were increased in number who had bothdiabetes mellitus and impaired fasting glucose. According to age diabetes mellitus increased in age groups between 41-50 and 61-70years while impaired fasting glucose were increased in age group between 31-60 yrs. The results indicate that impaired fasting glucose ispresent in significant number of hypertensive patients. Conclusions: Hypertension is associated with diabetes mellitus and impairedfasting glucose.

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The effect of breastfeeding on postpartum glucose tolerance and lipid profiles in women with gestational diabetes mellitus

International Breastfeeding Journal ◽

10.1186/s13006-019-0238-5 ◽

2019 ◽

Vol 14 (1) ◽

Cited By ~ 3

Author(s):

Alexis Shub ◽

Manisha Miranda ◽

Harry M. Georgiou ◽

Elizabeth A. McCarthy ◽

Martha Lappas

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Exclusive Breastfeeding ◽

Fasting Glucose ◽

Density Lipoprotein ◽

Lipid Profiles ◽

Lipoprotein Cholesterol ◽

Maternal Body Mass Index ◽

Glucose Levels

Abstract Background We aimed to investigate the association of breastfeeding on postpartum glucose levels and lipid profiles in women diagnosed with gestational diabetes mellitus (GDM) and women without GDM. Methods We performed a secondary analysis of a cohort study of 243 women, 159 women with GDM and 84 normally glucose tolerant women between 2012 and 2017. At approximately 6–10 weeks postpartum, we measured fasting blood glucose and plasma lipid levels. Breastfeeding behaviour was self-defined as exclusive breastfeeding or not exclusive breastfeeding. Results The mean (SD) glucose in the group of women who breastfed exclusively was 4.6 (0.49) mmol/L, compared to 4.9 (0.58) mmol/L (95% CI 0.45, 0.15, p < 0.001) among women who did not exclusively breastfeed. Among women with GDM, the reduction in fasting glucose in women who were breastfeeding was 0.22 mmol/L (95% CI 0.39, 0.05, p = 0.004), and in women who were not GDM, the reduction was 0.14 mmol/L (95% CI 0.37, 0.09, p = 0.24,). After adjustment for GDM status in pregnancy, maternal body mass index (BMI), maternal age and ethnicity, and exclusive breastfeeding was associated with a decreased fasting glucose of 0.19 (95% CI 0.318, 0.061, p = 0.004). After similar adjustment, there was no significant difference in triglycerides, high density lipoprotein cholesterol or low-density lipoprotein cholesterol between women who were breastfeeding and women who were not breastfeeding. Conclusions Breastfeeding is associated with a reduction in fasting glucose levels postpartum, but not maternal lipid profile. Breastfeeding may play a role in reducing glucose intolerance in women who have had GDM.

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Impaired Fasting Glucose and the Risk of Incident Diabetes Mellitus and Cardiovascular Events

Journal of the American College of Cardiology ◽

10.1016/j.jacc.2011.07.049 ◽

2011 ◽

Vol 58 (24) ◽

pp. 2546-2547 ◽

Cited By ~ 1

Author(s):

Saurav Chatterjee ◽

Subhankar Maitra

Keyword(s):

Diabetes Mellitus ◽

Impaired Fasting Glucose ◽

Cardiovascular Events ◽

Fasting Glucose ◽

Incident Diabetes

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Impaired Fasting Glucose and the Risk of Incident Diabetes Mellitus and Cardiovascular Events in an Adult Population

Journal of the American College of Cardiology ◽

10.1016/j.jacc.2011.03.025 ◽

2011 ◽

Vol 58 (2) ◽

pp. 140-146 ◽

Cited By ~ 52

Author(s):

Joseph Yeboah ◽

Alain G. Bertoni ◽

David M. Herrington ◽

Wendy S. Post ◽

Gregory L. Burke

Keyword(s):

Diabetes Mellitus ◽

Impaired Fasting Glucose ◽

Cardiovascular Events ◽

Fasting Glucose ◽

Adult Population ◽

Incident Diabetes

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Degree of Blood Pressure Control and Incident Diabetes Mellitus in Chinese Adults With Hypertension

Journal of the American Heart Association ◽

10.1161/jaha.120.017015 ◽

2020 ◽

Vol 9 (16) ◽

Author(s):

Yuanyuan Zhang ◽

Jing Nie ◽

Yan Zhang ◽

Jianping Li ◽

Min Liang ◽

...

Keyword(s):

Diabetes Mellitus ◽

Blood Pressure ◽

Propensity Scores ◽

Fasting Glucose ◽

Pressure Control ◽

Incident Diabetes ◽

Chinese Adults ◽

Normal Fasting Glucose ◽

Diagnosed Diabetes

Background The association between blood pressure (BP) control and incident diabetes mellitus remains unknown. We aim to investigate the association between degree of time‐averaged on‐treatment systolic blood pressure (SBP) control and incident diabetes mellitus in hypertensive adults. Methods and Results A total of 14 978 adults with hypertension without diabetes mellitus at baseline were included from the CSPPT (China Stroke Primary Prevention Trial). Participants were randomized double‐masked to daily enalapril 10 mg and folic acid 0.8 mg or enalapril 10 mg alone. BP measurements were taken every 3 months after randomization. The primary outcome was incident diabetes mellitus, defined as physician‐diagnosed diabetes mellitus, or use of glucose‐lowering drugs during follow‐up, or fasting glucose ≥126 mg/dL at the exit visit. Over a median of 4.5 years, a significantly higher risk of incident diabetes mellitus was found in participants with time‐averaged on‐treatment SBP 130 to <140 mm Hg (10.3% versus 7.4%; odds ratio [OR], 1.37; 95% CI, 1.15‒1.64), compared with those with SBP 120 to <130 mm Hg. Moreover, the risk of incident diabetes mellitus increased by 24% (OR, 1.24; 95% CI, 1.00‒1.53) and the incidence of regression to normal fasting glucose (<100 mg/dL) decreased by 29% (OR, 0.71; 95% CI, 0.57‒0.89) in participants with intermediate BP control (SBP/diastolic blood pressure, 130 to <140 and/or 80 to <90 mm Hg), compared with those with a tight BP control of <130/<80 mm Hg. Similar results were found when the time‐averaged BP were calculated using the BP measurements during the first 6‐ or 24‐month treatment period, or in the analysis using propensity scores. Conclusions In this non‐diabetic, hypertensive population, SBP control in the range of 120 to <130 mm Hg, compared with the 130 to <140 mm Hg, was associated with a lower risk of incident diabetes mellitus.

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Abstract #207: The Impact of Diabetes Mellitus and Fasting Glucose Levels on Clinical Outcomes in Colorectal Cancer.

Endocrine Practice ◽

10.1016/s1530-891x(20)42513-3 ◽

2015 ◽

Vol 21 ◽

pp. 26-27

Author(s):

Narjust Duma ◽

Genevieve Streb ◽

Sandra Aleksic ◽

Daniel Pievsky ◽

Larysa Sanchez ◽

...

Keyword(s):

Diabetes Mellitus ◽

Colorectal Cancer ◽

Clinical Outcomes ◽

Fasting Glucose ◽

Glucose Levels ◽

The Impact

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Associations of Vitamin D Level and Glucoregulatory Parameters in Type 2 Diabetes Mellitus

Serbian Journal of Experimental and Clinical Research ◽

10.2478/sjecr-2019-0054 ◽

2019 ◽

Vol 0 (0) ◽

Author(s):

Andrea Zubnar ◽

Stanislava Nikolic ◽

Damir Benc ◽

Nebojsa Janjic ◽

Mina Maricic ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Vitamin D ◽

Type 2 Diabetes Mellitus ◽

Hemoglobin A1c ◽

Fasting Glucose ◽

Newly Diagnosed ◽

Glucose Levels ◽

Vitamin D Levels

Abstract Vitamin D is known to affect the functions of pancreatic beta cells, but the effects of vitamin D deficiency on glucoregulatory mechanisms are still inconclusive. The aim of this study was to link vitamin D levels with parameters of insulin resistance and insulin secretion. The study included 70 male and female participants, 40 newly diagnosed patients with type 2 diabetes mellitus (T2DM) and 30 healthy controls. All participants were tested for fasting glucose, hemoglobin A1c, fasting insulin, vitamin D levels, and the HOMA indexes were calculated using HOMA2 calculator. Fasting glucose levels, insulinemia, hemoglobin A1c levels and HOMA IR were all significantly higher in the diabetic group (p<0.001), while vitamin D levels and HOMA S index were significantly lower (p<0.001). HOMA-B values did not differ between the two groups (p=0.31). Vitamin D levels moderately correlated with HOMA S and HOMA B indexes (r=0.466, p<0.001; r=0.394, p<0.001, respectively), whereas a negative correlation was found between vitamin D levels and HOMA IR (r=−0.285; p<0.001). Multiple regression analysis showed that vitamin D levels significantly predicted the values of HOMA B index (p=0.001), but they had no predictive value on HOMA IR (p=0.26). In conclusion, the group of newly diagnosed patients with T2DM showed significantly lower vitamin D values compared to the healthy control group. The connection between vitamin D, glucose levels, hemoglobin A1c and insulin secretion index underlines the role of this vitamin in glucoregulation.

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