Potential Role of Febrile Seizures and Other Risk Factors Associated With Sudden Deaths in Children

: COVID-19 or SARS-CoV-2 or 2019-nCov is a pandemic disease that occurred in December 2019 from Wuhan, Hubei Province of China. It was first transmitted from the animal host to a human source, after which it followed human-human transmission and spread exponentially worldwide. Various countries have fallen prey to this virus, but there are certain countries or populations, which have been more affected by this than others. Moreover, the demographics of transmission and affected individuals are also variable from country-country. The purpose of this article is to highlight the non-modifiable risk factors for COVID-19 and their analysis in various populations affecting their susceptibility. Besides age, gender, and blood group, two major genetic factors associated with this disease are discussed here including the potential of IL-6, in causing chronic disease conditions and the rs1800795 G/C-174 IL-6 polymorphism in the IL-6 gene and with the potential role of ACE-2 receptor in viral transmission and pathogenicity with its protective and disease-causing variants.

Download Full-text

Risk factors associated with myasthenia gravis in thymoma patients: The potential role of thymic germinal centers

Journal of Autoimmunity ◽

10.1016/j.jaut.2019.102337 ◽

2020 ◽

Vol 106 ◽

pp. 102337 ◽

Cited By ~ 1

Author(s):

Claire MJ. Lefeuvre ◽

Cloé A. Payet ◽

Odessa-Maud Fayet ◽

Solène Maillard ◽

Frédérique Truffault ◽

...

Keyword(s):

Risk Factors ◽

Myasthenia Gravis ◽

Potential Role ◽

Germinal Centers ◽

Factors Associated

Download Full-text

Role of β-Adrenergic Receptors and Nitric Oxide Signaling in Exercise-Mediated Cardioprotection

Physiology ◽

10.1152/physiol.00011.2013 ◽

2013 ◽

Vol 28 (4) ◽

pp. 216-224 ◽

Cited By ~ 21

Author(s):

John W. Calvert ◽

David J. Lefer

Keyword(s):

Nitric Oxide ◽

Risk Factors ◽

Adrenergic Receptors ◽

Ischemia Reperfusion Injury ◽

Ischemia Reperfusion ◽

Nitric Oxide Signaling ◽

Factors Associated ◽

Cardioprotective Effects ◽

Β Adrenergic Receptors

Exercise promotes cardioprotection in both humans and animals not only by reducing risk factors associated with cardiovascular disease but by reducing myocardial infarction and improving survival following ischemia. This article will define the role that nitric oxide and β-adrenergic receptors play in mediating the cardioprotective effects of exercise in the setting of ischemia-reperfusion injury.

Download Full-text

Risk factors associated with delirium in a general ICU: role of S-100 protein

Critical Care ◽

10.1186/cc6734 ◽

2008 ◽

Vol 12 (Suppl 2) ◽

pp. P513

Author(s):

A Rubino ◽

F Forfori ◽

G Licitra ◽

P Cosimini ◽

F Foltran ◽

...

Keyword(s):

Risk Factors ◽

Factors Associated ◽

S 100

Download Full-text

ROLE OF VARIOUS RISK FACTORS ASSOCIATED WITH CARDIOVASCULAR DISEASES

International Research Journal of Pharmacy ◽

10.7897/2230-8407.04511 ◽

2013 ◽

Vol 4 (5) ◽

pp. 44-50

Author(s):

Pranay Wal ◽

Ankita Wal ◽

Nikita Saraswat ◽

Shalini Singh ◽

Shikha Bajpai

Keyword(s):

Risk Factors ◽

Cardiovascular Diseases ◽

Factors Associated

Download Full-text

Towards a Consensus on Alzheimer’s Disease Comorbidity?

Journal of Clinical Medicine ◽

10.3390/jcm10194360 ◽

2021 ◽

Vol 10 (19) ◽

pp. 4360

Author(s):

Iska Avitan ◽

Yudit Halperin ◽

Trishna Saha ◽

Naamah Bloch ◽

Dana Atrahimovich ◽

...

Keyword(s):

Risk Factors ◽

Heart Failure ◽

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Potential Role ◽

Oxygen Species ◽

Degenerative Diseases ◽

Comorbid Diseases

Alzheimer’s disease (AD) is often comorbid with other pathologies. First, we review shortly the diseases most associated with AD in the clinic. Then we query PubMed citations for the co-occurrence of AD with other diseases, using a list of 400 common pathologies. Significantly, AD is found to be associated with schizophrenia and psychosis, sleep insomnia and apnea, type 2 diabetes, atherosclerosis, hypertension, cardiovascular diseases, obesity, fibrillation, osteoporosis, arthritis, glaucoma, metabolic syndrome, pain, herpes, HIV, alcoholism, heart failure, migraine, pneumonia, dyslipidemia, COPD and asthma, hearing loss, and tobacco smoking. Trivially, AD is also found to be associated with several neurodegenerative diseases, which are disregarded. Notably, our predicted results are consistent with the previously published clinical data and correlate nicely with individual publications. Our results emphasize risk factors and promulgate diseases often associated with AD. Interestingly, the comorbid diseases are often degenerative diseases exacerbated by reactive oxygen species, thus underlining the potential role of antioxidants in the treatment of AD and comorbid diseases.

Download Full-text

The Exploration of Poor Ovarian Response–Related Risk Factors: A Potential Role of Growth Differentiation Factor 8 in Predicting Ovarian Response in IVF-ET Patient

Frontiers in Endocrinology ◽

10.3389/fendo.2021.708089 ◽

2021 ◽

Vol 12 ◽

Author(s):

Long Bai ◽

Huihui Pan ◽

Yinjun Zhao ◽

Qingqing Chen ◽

Yu Xiang ◽

...

Keyword(s):

Risk Factors ◽

Growth Factor ◽

Potential Role ◽

Transforming Growth Factor ◽

Ovarian Response ◽

Poor Ovarian Response ◽

Aberrant Expression ◽

Differentiation Factor ◽

Ivf Et

Controlled ovarian hyperstimulation (COH) is the most common therapeutic protocol to obtain a considerable number of oocytes in IVF-ET cycles. To date, the risk factors affecting COH outcomes remain elusive. Growth differentiation factor 8 (GDF-8), a member of transforming growth factor β (TGF-β) superfamily, has been long discerned as a crucial growth factor in folliculogenesis, and the aberrant expression of GDF-8 is closely correlated with the reproductive diseases. However, less is known about the level of GDF-8 in IVF-ET patients with different ovarian response. In the present study, the potential risk factors correlated with ovarian response were explored using logistic regression analysis methods. Meanwhile, the expression changes of GDF-8 and its responsible cellular receptors in various ovarian response patients were determined. Our results showed that several factors were intensely related to poor ovarian response (POR), including aging, obesity, endometriosis, surgery history, and IVF treatment, while irregular menstrual cycles and PCOS contribute to hyperovarian response (HOR). Furthermore, POR patients exhibited a decrease in numbers of MII oocytes and available embryos, thereby manifesting a lower clinical pregnancy rate. The levels of GDF-8, ALK5, and ACVR2B in POR patients were higher compared with those in control groups, whereas the expression level of ACVR2A decreased in poor ovarian response patients. In addition, clinical correlation analysis results showed that the concentration of GDF-8 was negatively correlated with LH and estradiol concentration and antral follicle count. Collectively, our observations provide a novel insight of ovarian response–associated risk factors, highlighting the potential role of GDF-8 levels in ovarian response during COH process.

Download Full-text

The Role of MicroRNAs in Selected Forms of Glomerulonephritis

International Journal of Molecular Sciences ◽

10.3390/ijms20205050 ◽

2019 ◽

Vol 20 (20) ◽

pp. 5050 ◽

Cited By ~ 2

Author(s):

Magdalena Nalewajska ◽

Klaudia Gurazda ◽

Ewa Styczyńska-Kowalska ◽

Małgorzata Marchelek-Myśliwiec ◽

Andrzej Pawlik ◽

...

Keyword(s):

Risk Factors ◽

Immune System ◽

Genetic Risk ◽

Potential Role ◽

Kidney Diseases ◽

Diagnostic Techniques ◽

Targeted Treatments ◽

Harmful Effects ◽

Insight Into

Glomerulonephritis (GN) represents a collection of kidney diseases characterized by inflammation within the renal glomeruli and small blood vessels. The lesions that occur in other nephron structures mainly result from the harmful effects of proteinuria. In recent years, an emphasis has been placed on gaining a better insight into the pathogenesis and pathophysiology of GN in order to facilitate diagnoses and provide efficient and targeted treatments of the disease. Owing to the advanced molecular and genetic diagnostic techniques available today, researchers have been able to elucidate that most cases of GN are determined by genetic risk factors and are associated with the abnormal functioning of the immune system (the immunologically mediated forms of GN). MicroRNAs (miRNAs) are a group of single-stranded, non-coding molecules, approximately 20 nucleotides in length, that act as regulatory factors in the post-transcriptional processes capable of regulating the expression of multiple genes. In this paper we present the available research aiming to determine effects of miRNAs on the development and progression of GN and discuss the potential role of miRNAs as new diagnostic markers and therapeutic targets.

Download Full-text