Natural-Based and Stimuli-Responsive Polymers for Tissue Engineering and Regenerative Medicine

2015 ◽  
pp. 49-90 ◽  
Author(s):  
Mariana B. Oliveira ◽  
João F. Mano
Keyword(s):  
Tissue Engineering ◽  
Regenerative Medicine ◽  
Stimuli Responsive ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers

scholarly journals Stimuli-Responsive Materials for Tissue Engineering and Drug Delivery

2020 ◽  
Vol 21 (13) ◽  
pp. 4724 ◽  
Author(s):  
Sofia Municoy ◽  
María I. Álvarez Echazú ◽  
Pablo E. Antezana ◽  
Juan M. Galdopórpora ◽  
Christian Olivetti ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Smart Materials ◽  
Controlled Drug Release ◽  
Stimuli Responsive ◽  
Responsive Materials ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers ◽  
Stimuli Response ◽  
Materials Used

Smart or stimuli-responsive materials are an emerging class of materials used for tissue engineering and drug delivery. A variety of stimuli (including temperature, pH, redox-state, light, and magnet fields) are being investigated for their potential to change a material’s properties, interactions, structure, and/or dimensions. The specificity of stimuli response, and ability to respond to endogenous cues inherently present in living systems provide possibilities to develop novel tissue engineering and drug delivery strategies (for example materials composed of stimuli responsive polymers that self-assemble or undergo phase transitions or morphology transformations). Herein, smart materials as controlled drug release vehicles for tissue engineering are described, highlighting their potential for the delivery of precise quantities of drugs at specific locations and times promoting the controlled repair or remodeling of tissues.

Stimuli Responsive Matrices for Medical Applications

2015 ◽  
Vol 638 ◽  
pp. 249-254
Author(s):  
Raluca Petronela Dumitriu ◽  
Daniela Pamfil ◽  
Manuela Tatiana Nistor ◽  
Cornelia Vasile
Keyword(s):  
Tissue Engineering ◽  
Medical Application ◽  
Controlled Delivery ◽  
Hydroxyethyl Methacrylate ◽  
Stimuli Responsive ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers ◽  
Hybrid Hydrogels ◽  
Isopropyl Acrylamide ◽  
Different Types

Different types of stimuli responsive polymers that respond with a property change to a variation in the environmental conditions are an attractive class of materials for advanced applications in biomedical or pharmaceutical fields. Three types of responsive biocompatible and biodegradable polymer matrices are presented as potential biomaterials for medical application as carriers for various drugs and tissue engineering substitutes. Hybrid hydrogels based on collagen/ N-isopropyl acrylamide containing montmorillonite nanoparticles are promising materials for tissue engineering and also as carriers for norfloxacin, a chemotherapeutic antibacterial agent. Semi-interpenetrated hydrogels based either on substituted anhydride modified collagen and 2-hydroxyethyl methacrylate or on alginate and poly (N-isopropylacrylamide) were tested as matrices for the controlled delivery of bisoprolol fumarate, an antihypertensive drug and respectively of ketoprofen, a non-steroidal anti-inflammatory drug.

scholarly journals Fabrication of polymeric biomaterials: a strategy for tissue engineering and medical devices

2015 ◽  
Vol 3 (42) ◽  
pp. 8224-8249 ◽  
Author(s):  
Ferdous Khan ◽  
Masaru Tanaka ◽  
Sheikh Rafi Ahmad
Keyword(s):  
Tissue Engineering ◽  
Tissue Regeneration ◽  
Medical Devices ◽  
Self Assembly ◽  
Stimuli Responsive ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers ◽  
Polymeric Biomaterials ◽  
Methods And Techniques ◽  
Printing Techniques

Fabrication of biomaterials scaffolds using various methods and techniques is discussed, utilising biocompatible, biodegradable and stimuli-responsive polymers and their composites. This review covers the lithography and printing techniques, self-organisation and self-assembly methods for 3D structural scaffolds generation, and smart hydrogels, for tissue regeneration and medical devices.

Molecularly Engineered Polymer-Based Systems in Drug Delivery and Regenerative Medicine

2017 ◽  
Vol 23 (2) ◽  
pp. 281-294 ◽  
Author(s):  
Susanna Piluso ◽  
Al Halifa Soultan ◽  
Jennifer Patterson
Keyword(s):  
Drug Delivery ◽  
Regenerative Medicine ◽  
Local Environment ◽  
Stimuli Responsive ◽  
Controlled Polymerization ◽  
Polymer Therapeutics ◽  
Protein Conjugates ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers ◽  
Drug Conjugates

Background: Polymer-based systems are attractive in drug delivery and regenerative medicine due to the possibility of tailoring their properties and functions to a specific application. Methods: The present review provides several examples of molecularly engineered polymer systems, including stimuli responsive polymers and supramolecular polymers. Results: The advent of controlled polymerization techniques has enabled the preparation of polymers with controlled molecular weight and well-defined architecture. By using these techniques coupled to orthogonal chemical modification reactions, polymers can be molecularly engineered to incorporate functional groups able to respond to small changes in the local environment or to a specific biological signal. This review highlights the properties and applications of stimuli-responsive systems and polymer therapeutics, such as polymer-drug conjugates, polymer-protein conjugates, polymersomes, and hyperbranched systems. The applications of polymeric membranes in regenerative medicine are also discussed. Conclusion: The examples presented in this review suggest that the combination of membranes with polymers that are molecularly engineered to respond to specific biological functions could be relevant in the field of regenerative medicine.

Amino-functional polyethers: versatile, stimuli-responsive polymers

2020 ◽  
Vol 11 (24) ◽  
pp. 3940-3950 ◽  
Author(s):  
Patrick Verkoyen ◽  
Holger Frey
Keyword(s):  
Ring Opening ◽  
Review Article ◽  
Stimuli Responsive ◽  
New Class ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers

Amino-functional polyethers have emerged as a new class of “smart”, i.e. pH- and thermoresponsive materials. This review article summarizes the synthesis and applications of these materials, obtained from ring-opening of suitable epoxide monomers.

Smart Drug Release Systems Based on Stimuli-Responsive Polymers

2013 ◽  
Vol 13 (9) ◽  
pp. 1369-1380 ◽  
Author(s):  
Guangyan Qing ◽  
Minmin Li ◽  
Lijing Deng ◽  
Ziyu Lv ◽  
Peng Ding ◽  
...  
Keyword(s):  
Drug Release ◽  
Stimuli Responsive ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers ◽  
Smart Drug

scholarly journals Thermo- and Photoresponsive Behaviors of Dual-Stimuli-Responsive Organogels Consisting of Homopolymers of Coumarin-Containing Methacrylate

Polymers ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 329
Author(s):  
Seidai Okada ◽  
Eriko Sato
Keyword(s):  
Functional Group ◽  
Solution Temperature ◽  
Stimuli Responsive ◽  
Critical Solution Temperature ◽  
Equilibrium Degree ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers ◽  
Dual Functional ◽  
Wide Range ◽  
Increasing Temperature

Coumarin-containing vinyl homopolymers, such as poly(7-methacryloyloxycoumarin) (P1a) and poly(7-(2′-methacryloyloxyethoxy)coumarin) (P1b), show a lower critical solution temperature (LCST) in chloroform, which can be controlled by the [2 + 2] photochemical cycloaddition of the coumarin moiety, and they are recognized as monofunctional dual-stimuli-responsive polymers. A single functional group of monofunctional dual-stimuli-responsive polymers responds to dual stimuli and can be introduced more uniformly and densely than those of dual-functional dual-stimuli-responsive polymers. In this study, considering a wide range of applications, organogels consisting of P1a and P1b, i.e., P1a-gel and P1b-gel, respectively, were synthesized, and their thermo- and photoresponsive behaviors in chloroform were investigated in detail. P1a-gel and P1b-gel in a swollen state (transparent) exhibited phase separation (turbid) through a temperature jump and reached a shrunken state (transparent), i.e., an equilibrium state, over time. Moreover, the equilibrium degree of swelling decreased non-linearly with increasing temperature. Furthermore, different thermoresponsive sites were photopatterned on the organogel through the photodimerization of the coumarin unit. The organogels consisting of homopolymers of coumarin-containing methacrylate exhibited unique thermo- and photoresponsivities and behaved as monofunctional dual-stimuli-responsive organogels.

scholarly journals Metal-Organic Framework-Based Stimuli-Responsive Polymers

2021 ◽  
Vol 5 (4) ◽  
pp. 101
Author(s):  
Menglian Wei ◽  
Yu Wan ◽  
Xueji Zhang
Keyword(s):  
Metal Organic Framework ◽  
Chemical Properties ◽  
Stimuli Responsive ◽  
Guest Molecules ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers ◽  
Reversible Phase Transition ◽  
Metal Organic ◽  
External Stimuli ◽  
Organic Framework

Metal-organic framework (MOF) based stimuli-responsive polymers (coordination polymers) exhibit reversible phase-transition behavior and demonstrate attractive properties that are capable of altering physical and/or chemical properties upon exposure to external stimuli, including pH, temperature, ions, etc., in a dynamic fashion. Thus, their conformational change can be imitated by the adsorption/desorption of target analytes (guest molecules), temperature or pressure changes, and electromagnetic field manipulation. MOF-based stimuli responsive polymers have received great attention due to their advanced optical properties and variety of applications. Herein, we summarized some recent progress on MOF-based stimuli-responsive polymers (SRPs) classified by physical and chemical responsiveness, including temperature, pressure, electricity, pH, metal ions, gases, alcohol and multi-targets.

Stimuli-Responsive Polymers for Soft Robotics

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Yusen Zhao ◽  
Mutian Hua ◽  
Yichen Yan ◽  
Shuwang Wu ◽  
Yousif Alsaid ◽  
...  
Keyword(s):  
Autonomous Systems ◽  
Soft Robotics ◽  
Annual Review ◽  
Liquid Crystal Polymers ◽  
Publication Date ◽  
Stimuli Responsive ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers ◽  
Evaluation Of Performance ◽  
Robotic Applications

This article reviews recent progress in the use of stimuli-responsive polymers for soft robotics. First, we introduce different types of representative stimuli-responsive polymers, which include liquid crystal polymers and elastomers, hydrogels, shape memory polymers, magnetic elastomers, electroactive polymers, and thermal expansion actuators. We focus on the mechanisms of actuation and the evaluation of performance and discuss strategies for improvements. We then present examples of soft robotic applications based on stimuli-responsive polymers for bending, grasping, walking, swimming, flying, and sensing control. Finally, we discuss current opportunities and challenges of stimuli-responsive soft robots for future study. Expected final online publication date for the Annual Review of Control, Robotics, and Autonomous Systems, Volume 5 is May 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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