A Facile, Protein‐derived Supramolecular Theranostic Strategy for Multimodal‐imaging‐guided Photodynamic and Photothermal Immunotherapy in vivo

Alzheimer’s disease is the most common form of dementia and is a significant burden for affected patients, carers, and health systems. Great advances have been made in understanding its pathophysiology, to a point that we are moving from a purely clinical diagnosis to a biological one based on the use of biomarkers. Among those, imaging biomarkers are invaluable in Alzheimer’s, as they provide an in vivo window to the pathological processes occurring in Alzheimer’s brain. While some imaging techniques are still under evaluation in the research setting, some have reached widespread clinical use. In this review, we provide an overview of the most commonly used imaging biomarkers in Alzheimer’s disease, from molecular PET imaging to structural MRI, emphasising the concept that multimodal imaging would likely prove to be the optimal tool in the future of Alzheimer’s research and clinical practice.

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Cerebral dopaminergic and glutamatergic transmission relate to different subjective responses of acute alcohol intake: an in vivo multimodal imaging study

Addiction Biology ◽

10.1111/adb.12542 ◽

2017 ◽

Vol 23 (3) ◽

pp. 931-944 ◽

Cited By ~ 14

Author(s):

Gil Leurquin-Sterk ◽

Jenny Ceccarini ◽

Cleo Lina Crunelle ◽

Akila Weerasekera ◽

Bart de Laat ◽

...

Keyword(s):

Multimodal Imaging ◽

Alcohol Intake ◽

Imaging Study ◽

Glutamatergic Transmission ◽

Subjective Responses

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Dual-Modal In Vivo Fluorescence/Photoacoustic Microscopy Imaging of Inflammation Induced by GFP-Expressing Bacteria

Sensors ◽

10.3390/s19020238 ◽

2019 ◽

Vol 19 (2) ◽

pp. 238 ◽

Cited By ~ 1

Author(s):

Yubin Liu ◽

Lei Fu ◽

Mengze Xu ◽

Jun Zheng ◽

Zhen Yuan

Keyword(s):

Multimodal Imaging ◽

Fluorescent Protein ◽

Biological Tissues ◽

Photoacoustic Microscopy ◽

Microscopy Imaging ◽

Enhanced Sensitivity ◽

Imaging Results ◽

Molecular Specificity ◽

Green Fluorescent

In this study, dual-modal fluorescence and photoacoustic microscopy was performed for noninvasive and functional in vivo imaging of inflammation induced by green fluorescent protein (GFP) transfected bacteria in mice ear. Our imaging results demonstrated that the multimodal imaging technique is able to monitor the tissue immunovascular responses to infections with molecular specificity. Our study also indicated that the combination of photoacoustic and fluorescence microscopy imaging can simultaneously track the biochemical changes including the bacterial distribution and morphological change of blood vessels in the biological tissues with high resolution and enhanced sensitivity. Consequently, the developed method paves a new avenue for improving the understanding of the pathology mechanism of inflammation.

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Laser injury and in vivo multimodal imaging using a mouse model

10.1117/12.873979 ◽

2011 ◽

Author(s):

Ginger M. Pocock ◽

Adam Boretsky ◽

Praveena Gupta ◽

Jeff W. Oliver ◽

Massoud Motamedi

Keyword(s):

Mouse Model ◽

Multimodal Imaging ◽

Laser Injury

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An In Vivo Multimodal Imaging Study Using MRI and PET of Stem Cell Transplantation after Myocardial Infarction in Rats

Molecular Imaging and Biology ◽

10.1007/s11307-008-0174-z ◽

2008 ◽

Vol 11 (1) ◽

pp. 31-38 ◽

Cited By ~ 32

Author(s):

Catherine Chapon ◽

Johanna S. Jackson ◽

Eric O. Aboagye ◽

Amy H. Herlihy ◽

William A. Jones ◽

...

Keyword(s):

Myocardial Infarction ◽

Stem Cell ◽

Stem Cell Transplantation ◽

Cell Transplantation ◽

Multimodal Imaging ◽

Imaging Study

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Silica micro/nanospheres for theranostics: from bimodal MRI and fluorescent imaging probes to cancer therapy

Beilstein Journal of Nanotechnology ◽

10.3762/bjnano.6.57 ◽

2015 ◽

Vol 6 ◽

pp. 546-558 ◽

Cited By ~ 17

Author(s):

Shanka Walia ◽

Amitabha Acharya

Keyword(s):

Multimodal Imaging ◽

Fluorescent Imaging ◽

Full Description ◽

Cytotoxic Effects ◽

Characterization Methods ◽

Bimodal Imaging ◽

Nanoparticle Surface ◽

Imaging Probes ◽

Low Toxicity

Nano-theranostics offer remarkable potential for future biomedical technology with simultaneous applications for diagnosis and therapy of disease sites. Through smart and careful chemical modifications of the nanoparticle surface, these can be converted to multifunctional tiny objects which in turn can be used as vehicle for delivering multimodal imaging agents and therapeutic material to specific target sites in vivo. In this sense, bimodal imaging probes that simultaneously enable magnetic resonance imaging and fluorescence imaging have gained tremendous attention because disease sites can be characterized quick and precisely through synergistic multimodal imaging. But such hybrid nanocomposite materials have limitations such as low chemical stability (magnetic component) and harsh cytotoxic effects (fluorescent component) and, hence, require a biocompatible protecting agent. Silica micro/nanospheres have shown promise as protecting agent due to the high stability and low toxicity. This review will cover a full description of MRI-active and fluorescent multifunctional silica micro/nanospheres including the design of the probe, different characterization methods and their application in imaging and treatment in cancer.

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