Electric Polarity-Dependent Modification of the Fe/BaTiO3Interface

2015 ◽  
Vol 3 (4) ◽  
pp. 1500433 ◽  
Author(s):  
Manisha Bisht ◽  
Sebastien Couet ◽  
Vera Lazenka ◽  
Hiwa Modarresi ◽  
Rudolf Rüffer ◽  
...  
Keyword(s):  
Electric Polarity ◽  
Dependent Modification

Does human myocardium show a gender dependent modification of oxidative stress parameters?

2014 ◽  
Vol 62 (S 01) ◽  
Author(s):  
K. Buschmann ◽  
Y. Gramlich ◽  
M. Oelze ◽  
A. Daiber ◽  
T. Münzel ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Human Myocardium ◽  
Oxidative Stress Parameters ◽  
Dependent Modification ◽  
Stress Parameters

scholarly journals Confinement effects for rubberised concrete in tubular steel cross-sections under combined loading

2021 ◽  
Vol 21 (2) ◽  
Author(s):  
A. Mujdeci ◽  
D. V. Bompa ◽  
A. Y. Elghazouli
Keyword(s):  
Axial Compression ◽  
Cross Section ◽  
Cross Sections ◽  
Image Correlation ◽  
Combined Loading ◽  
Test Results ◽  
Compression Tests ◽  
Confinement Effects ◽  
Rubber Content ◽  
Dependent Modification

AbstractThis paper describes an experimental investigation into confinement effects provided by circular tubular sections to rubberised concrete materials under combined loading. The tests include specimens with 0%, 30% and 60% rubber replacement of mineral aggregates by volume. After describing the experimental arrangements and specimen details, the results of bending and eccentric compression tests are presented, together with complementary axial compression tests on stub-column samples. Tests on hollow steel specimens are also included for comparison purposes. Particular focus is given to assessing the confinement effects in the infill concrete as well as their influence on the axial–bending cross-section strength interaction. The results show that whilst the capacity is reduced with the increase in the rubber replacement ratio, an enhanced confinement action is obtained for high rubber content concrete compared with conventional materials. Test measurements by means of digital image correlation techniques show that the confinement in axial compression and the neutral axis position under combined loading depend on the rubber content. Analytical procedures for determining the capacity of rubberised concrete infilled cross-sections are also considered based on the test results as well as those from a collated database and then compared with available recommendations. Rubber content-dependent modification factors are proposed to provide more realistic representations of the axial and flexural cross-section capacities. The test results and observations are used, in conjunction with a number of analytical assessments, to highlight the main parameters influencing the behaviour and to propose simplified expressions for determining the cross-section strength under combined compression and bending.

scholarly journals Experience-dependent modification of a central amygdala fear circuit

2013 ◽  
Vol 16 (3) ◽  
pp. 332-339 ◽  
Author(s):  
Haohong Li ◽  
Mario A Penzo ◽  
Hiroki Taniguchi ◽  
Charles D Kopec ◽  
Z Josh Huang ◽  
...  
Keyword(s):  
Central Amygdala ◽  
Dependent Modification

scholarly journals Saccharomyces cerevisiae ubiquitin-like protein Rub1 conjugates to cullin proteins Rtt101 and Cul3 in vivo

2004 ◽  
Vol 377 (2) ◽  
pp. 459-467 ◽  
Author(s):  
Jose M. LAPLAZA ◽  
Magnolia BOSTICK ◽  
Derek T. SCHOLES ◽  
M. Joan CURCIO ◽  
Judy CALLIS
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Protein A ◽  
Fold Increase ◽  
Lysine Residue ◽  
Reading Frame ◽  
E3 Ligases ◽  
C Terminus ◽  
Dependent Modification ◽  
F Box Protein

In Saccharomyces cerevisiae, the ubiquitin-like protein Rub1p (related to ubiquitin 1 protein) covalently attaches to the cullin protein Cdc53p (cell division cycle 53 protein), a subunit of a class of ubiquitin E3 ligases named SCF (Skp1–Cdc53–F-box protein) complex. We identified Rtt101p (regulator of Ty transposition 101 protein, where Ty stands for transposon of yeast), initially found during a screen for proteins to confer retrotransposition suppression, and Cul3p (cullin 3 protein), a protein encoded by the previously uncharacterized open reading frame YGR003w, as two new in vivo targets for Rub1p conjugation. These proteins show significant identity with Cdc53p and, therefore, are cullin proteins. Modification of Cul3p is eliminated by deletion of the Rub1p pathway through disruption of either RUB1 or its activating enzyme ENR2/ULA1. The same disruptions in the Rub pathway decreased the percentage of total Rtt101p that is modified from approx. 60 to 30%. This suggests that Rtt101p has an additional RUB1- and ENR2-independent modification. All modified forms of Rtt101p and Cul3p were lost when a single lysine residue in a conserved region near the C-terminus was replaced by an arginine residue. These results suggest that this lysine residue is the site of Rub1p-dependent and -independent modifications in Rtt101p and of Rub1p-dependent modification in Cul3p. An rtt101Δ strain was hypersensitive to thiabendazole, isopropyl (N-3-chlorophenyl) carbamate and methyl methanesulphonate, but rub1Δ strains were not. Whereas rtt101Δ strains exhibited a 14-fold increase in Ty1 transposition, isogenic rub1Δ strains did not show statistically significant increases. Rtt101K791Rp, which cannot be modified, complemented for Rtt101p function in a transposition assay. Altogether, these results suggest that neither the RUB1-dependent nor the RUB1-independent form of Rtt101p is required for Rtt101p function. The identification of additional Rub1p targets in S. cerevisiae suggests an expanded role for Rub in this organism.

scholarly journals Coupling of L-Type Ca2+ Channels to KV7/KCNQ Channels Creates a Novel, Activity-Dependent, Homeostatic Intrinsic Plasticity

2008 ◽  
Vol 100 (4) ◽  
pp. 1897-1908 ◽  
Author(s):  
Wendy W. Wu ◽  
C. Savio Chan ◽  
D. James Surmeier ◽  
John F. Disterhoft
Keyword(s):  
Pyramidal Neurons ◽  
Firing Frequency ◽  
Fine Tuning ◽  
Membrane Excitability ◽  
Kcnq Channels ◽  
Central Neurons ◽  
Subsequent Activation ◽  
Intrinsic Plasticity ◽  
Dependent Modification ◽  
Activity Dependent

Experience-dependent modification in the electrical properties of central neurons is a form of intrinsic plasticity that occurs during development and has been observed following behavioral learning. We report a novel form of intrinsic plasticity in hippocampal CA1 pyramidal neurons mediated by the KV7/KCNQ and CaV1/L-type Ca2+ channels. Enhancing Ca2+ influx with a conditioning spike train (30 Hz, 3 s) potentiated the KV7/KCNQ channel function and led to a long-lasting, activity-dependent increase in spike frequency adaptation—a gradual reduction in the firing frequency in response to sustained excitation. These effects were abolished by specific blockers for CaV1/L-type Ca2+ channels, KV7/KCNQ channels, and protein kinase A (PKA). Considering the widespread expression of these two channel types, the influence of Ca2+ influx and subsequent activation of PKA on KV7/KCNQ channels may represent a generalized principle in fine tuning the output of central neurons that promotes stability in firing—an example of homeostatic regulation of intrinsic membrane excitability.

scholarly journals REDUCED REPRODUCTIVE SUCCESS FOR A CONDITIONING MUTANT IN EXPERIMENTAL POPULATIONS OF DROSOPHILA MELANOGASTER

Genetics ◽  
1985 ◽  
Vol 111 (4) ◽  
pp. 795-804
Author(s):  
Donald A Gailey ◽  
Jeffrey C Hall ◽  
Richard W Siegel
Keyword(s):  
Drosophila Melanogaster ◽  
Reproductive Success ◽  
Learning And Memory ◽  
Courtship Behavior ◽  
Virgin Female ◽  
Mating Advantage ◽  
Mating Efficiency ◽  
Normal Males ◽  
Time Required ◽  
Dependent Modification

ABSTRACT Male Drosophila melanogaster that have courted newly-emerged males can modify their subsequent courtship behavior to avoid further courtship with immature males for up to 6 hr (previously reported). Here, it was hypothesized that such an experience-dependent modification would afford a mating advantage to normal males over males that carried a mutation that affects learning and memory. Coisogenic lines were constructed which varied at the dunce gene (dnc  + and dnc  M14 alleles) in order to test this hypothesis. Whether previously experienced with immature males or not, dnc  + and dnc  M14 males were indistinguishable in their response and mating efficiency when individually paired with virgin females. However, courtship performance of dnc  + and dnc  M14 males was different if they were first experienced with immature males and were then individually tested in an artificial population of nine immature males and one virgin female. In this situation, dnc  + males spent much less time in courtship with immature males and achieved copulation in one-third the time required for dnc  M14 males. As a control, the behavior and mating efficiency of courtship-naive dnc  + and dnc  M14 males in the artificial population was indistinguishable. In competition for a single virgin female, experienced dnc  M14 males showed a slight mating advantage over experienced dnc  + males. But when competition by experienced males for a single virgin female took place in the presence of nine immature males, dnc  + males were the successful maters in three-fourths of the trials.

Cloning of trg, a gene for a sensory transducer in Escherichia coli

1982 ◽  
Vol 152 (1) ◽  
pp. 372-383
Author(s):  
S Harayama ◽  
P Engström ◽  
H Wolf-Watz ◽  
T Iino ◽  
G L Hazelbauer
Keyword(s):  
Escherichia Coli ◽  
High Resolution ◽  
Sodium Dodecyl Sulfate ◽  
Structural Gene ◽  
Preliminary Analysis ◽  
Sodium Dodecyl ◽  
Polyacrylamide Gels ◽  
Physiological Functions ◽  
The Common ◽  
Dependent Modification

Clones of trg, a gene which codes for a chemotactic transducer, were isolated linked to ColE1 and pBR322 vectors. Studies with the hybrid plasmids demonstrated unequivocally that trg is the structural gene for methyl-accepting chemotaxis protein III. The Trg protein was found to be structurally complex, electrophoresing as a series of seven bands on high-resolution sodium dodecyl sulfate-polyacrylamide gels. The multiplicity of bands is a function of the activity of cheR, which codes for a methyltransferase, and of cheB, which codes for a demethylase. It appears that Trg, a quantitatively minor transducer, resembles the two major transducer proteins, Tsr and Tar, in that all three are multiply methylated and also multiply modified in a second way which requires an active cheB gene. However, preliminary analysis of the Trg protein indicated that it is significantly less related structurally to the Tsr or Tar protein than those two transducers are to each other. This implies that the features of multiple methylation and cheB-dependent modification are likely to be critical for the common physiological functions in chemotactic excitation and adaptation performed by all three transducers.

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