Exploring the toxic effects and mechanism of methoxylated polybrominated diphenyl ethers (MeO‐PBDEs) on thyroxine‐binding globulin (TBG): Synergy between spectroscopic and computations

Luminescence ◽  
2021 ◽  
Author(s):  
Muwei Huang ◽  
Xiaomei Huang ◽  
Yanqiu Zuo ◽  
Zhongsheng Yi ◽  
Hongyan Liu
Keyword(s):  
Polybrominated Diphenyl Ethers ◽  
Toxic Effects ◽  
Thyroxine Binding Globulin ◽  
Diphenyl Ethers

scholarly journals Brominated Flame Retardants in the Environment: their Sources and Effects (A Review)

2006 ◽  
Vol 75 (4) ◽  
pp. 587-599 ◽  
Author(s):  
P. Mikula ◽  
Z. Svobodová
Keyword(s):  
Polybrominated Diphenyl Ethers ◽  
Hormonal Regulation ◽  
Flame Retardants ◽  
Brominated Flame Retardants ◽  
Toxic Effects ◽  
Potential Health ◽  
Diphenyl Ethers ◽  
Industrial Use ◽  
Living Organisms

Brominated flame retardants (BFRs) are organic substances frequently used in many industries. The most important group within BFRs are polybrominated diphenyl ethers (PBDEs). Because they persist in the environment, accumulate in food chains and have toxic effects, they are a potential health risk both for animals and humans. Polybrominated diphenyl ethers may disrupt processes of hormonal regulation in living organisms by reducing thyroxine concentrations in the plasma of the exposed individuals. In vitro studies have demonstrated the ability of these substances to bind to estrogen and androgen receptors. Tests on rodents have also demonstrated neurotoxicity of some of the PBDEs. Although industrial use of PBDEs is now regulated to a large extent, PBDEs have already been detected in areas with no apparent industrial load, e.g. in Greenland. This article presents an overview of BFRs-related issues with a particular emphasis on PBDEs, describes toxic effects of those substances and their metabolism in living organisms, and discusses issues related to the incidence of PBDEs in the environment.

The Toxic Effects of Polybrominated Diphenyl Ethers on Rotifer Branchionus plicatilis

2013 ◽  
Vol 807-809 ◽  
pp. 385-391 ◽  
Author(s):  
Jing Zhang ◽  
You Wang ◽  
Xue Xi Tang ◽  
Kuan Fang
Keyword(s):  
Treatment Group ◽  
Life Span ◽  
Polybrominated Diphenyl Ethers ◽  
Brachionus Plicatilis ◽  
Toxic Effects ◽  
Oxygen Species ◽  
Treatment Groups ◽  
Diphenyl Ethers ◽  
All Treatment ◽  
Bde 209

In the current study, two of the most environmentally relevant Polybrominated diphenyl ethers (PBDEs) were individually evaluated for toxic effects on rotifer Brachionus plicatilis. The results showed that the life span declined significantly in all treatment groups (0.05mg/L, 0.1mg/L, 0.2mg/L BDE-47 and BDE-209) compared to the control, and BDE-47 caused significant decrease compared to BDE-209 at 0.2mg/L treatment group. Significant increases of intracellular levels of reactive oxygen species (ROS) occurred in all treatment groups except for 0.05mg/L BDE-209 treatment group compared to the control, and significant increases were observed in all BDE-47 treatment groups compared to the equivalent treatment groups of BDE-209. Meanwhile significant increases of intracellular calcium levels ([Ca2+]in) occurred in 0.1mg/L, 0.2mg/L BDE-47 and 0.2mg/L BDE-209 treatment groups compared to the control, and BDE-47 cause significant increase compared to BDE-209 at 0.2mg/L treatment group. The present study demonstrated that life span, ROS and Ca2+ were involved in PBDEs toxic effects, and toxicities of BDE-47 were higher than BDE-209. Otherwise, the toxic effects in both BDE-47 and BDE-209 were similar, which suggest that the toxic effects of two PBDEs congeners may be caused by the same toxic mechanism of action.

Toxic effects of two commercial polybrominated diphenyl ethers on Artemia larvae at three developmental stages

Crustaceana ◽  
2021 ◽  
Vol 94 (2) ◽  
pp. 177-187
Author(s):  
Qingtian Zhang ◽  
Sifan Guo ◽  
Guikun Hu
Keyword(s):  
Developmental Stage ◽  
Polybrominated Diphenyl Ethers ◽  
Developmental Stages ◽  
Experimental Studies ◽  
Mortality Rates ◽  
The Body ◽  
Toxic Effects ◽  
Abnormal Behaviour ◽  
Diphenyl Ethers ◽  
Selection Of

Abstract Toxic effects of two commercial products, penta-BDE (DE-71) and octa-BDE (DE-79), on larvae of the brine shrimp, Artemia, were studied. Results showed that their toxic effects were related not only to the concentration and exposure time, but also to the developmental stage of Artemia. Newly hatched Artemia nauplii showed stronger tolerance than those at metanauplius stage or pseudoadult stage, while DE-71 showed a stronger toxic effect than DE-79 to some extent. Abnormal behaviour of Artemia larvae might occur within 12 h, and sometimes mortality rates increased quickly even if there was no death within 36 h. Both DE-71 and DE-79 showed significant influences on the body length of Artemia larvae within 24 h; the higher the concentration, the stronger the inhibition. As far as a toxic testing standard is concerned, further experimental studies on the selection of Artemia population and developmental stage are essential.

Association between prenatal exposure to polybrominated diphenyl ethers and anogenital distance in girls at ages 0–4 years

2021 ◽  
Vol 233 ◽  
pp. 113706
Author(s):  
Min Luan ◽  
Honglei Ji ◽  
Maohua Miao ◽  
Hong Liang ◽  
Ziliang Wang ◽  
...  
Keyword(s):  
Prenatal Exposure ◽  
Polybrominated Diphenyl Ethers ◽  
Anogenital Distance ◽  
Diphenyl Ethers

Polybrominated diphenyl ethers (PBDEs) in raw milk from different animal species and in infant formula. Occurrence and risk assessment

Chemosphere ◽  
2021 ◽  
pp. 130479
Author(s):  
Wojciech Jerzy Pietron ◽  
Malgorzata Warenik-Bany ◽  
Barbara Wozniak
Keyword(s):  
Risk Assessment ◽  
Infant Formula ◽  
Polybrominated Diphenyl Ethers ◽  
Animal Species ◽  
Raw Milk ◽  
Diphenyl Ethers
Sign in / Sign up

Export Citation Format

Share Document