Effect of phosphatidylcholine vesicle size on chirality induction and chiral discrimination

Chirality ◽  
2006 ◽  
Vol 18 (3) ◽  
pp. 212-216 ◽  
Author(s):  
Hiroko Nakagawa ◽  
Mayumi Onoda ◽  
Yuichi Masuoka ◽  
Koh-Ichi Yamada
Keyword(s):  
Chiral Discrimination ◽  
Vesicle Size ◽  
Phosphatidylcholine Vesicle ◽  
Chirality Induction

scholarly journals Membrane lipid composition and vesicle size modulate bilirubin intermembrane transfer. Evidence for membrane-directed trafficking of bilirubin in the hepatocyte.

1994 ◽  
Vol 269 (30) ◽  
pp. 19262-19270
Author(s):  
S.D. Zucker ◽  
W. Goessling ◽  
M.L. Zeidel ◽  
J.L. Gollan
Keyword(s):  
Lipid Composition ◽  
Membrane Lipid ◽  
Vesicle Size ◽  
Membrane Lipid Composition

scholarly journals Effect of vesicle size on their interaction with class A amphipathic helical peptides

1997 ◽  
Vol 38 (10) ◽  
pp. 2147-2154
Author(s):  
J A Gazzara ◽  
M C Phillips ◽  
S Lund-Katz ◽  
M N Palgunachari ◽  
J P Segrest ◽  
...  
Keyword(s):  
Helical Peptides ◽  
Vesicle Size ◽  
Class A

Electrochemiluminescent chiral discrimination with chiral Ag2S quantum dots/few-layer carbon nitride nanosheets

The Analyst ◽  
2021 ◽  
Author(s):  
Qianqian Zhao ◽  
Wenrong Cai ◽  
Bao-Zhu Yang ◽  
Zhengzhi Yin ◽  
Datong Wu ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Carbon Nitride ◽  
Chiral Discrimination ◽  
Chiral Ligand ◽  
Two Dimensional ◽  
Ag2s Quantum Dots ◽  
Carbon Nitride Nanosheets

Well dispersed chiral Ag2S quantum dots (Ag2S QDs) were facilely synthesized by using N-acetyl-L-cysteine (NALC) as the chiral ligand, which were loaded onto the nanosheets of two-dimensional (2D) few-layer carbon...

Chiral separation and analysis of antifungal drugs by chromatographic and electromigration techniques: Results achieved in 2010–2020

2021 ◽  
Vol 40 (1) ◽  
pp. 220-252
Author(s):  
Giovanni D’Orazio ◽  
Chiara Fanali ◽  
Chiara Dal Bosco ◽  
Alessandra Gentili ◽  
Salvatore Fanali
Keyword(s):  
Gas Chromatography ◽  
Pharmaceutical Industry ◽  
State Of The Art ◽  
Stationary Phases ◽  
Enantiomeric Separation ◽  
Antifungal Drugs ◽  
Chiral Discrimination ◽  
Food Science ◽  
Industry Environment ◽  
Metabolic Activities

Abstract The determination and separation of enantiomers is an interesting and important topic of research in various fields, e.g., biochemistry, food science, pharmaceutical industry, environment, etc. Although these compounds possess identical physicochemical properties, a pair of enantiomers often has different pharmacological, toxicological, and metabolic activities. For this reason, chiral discrimination by using chromatographic and electromigration techniques has become an urgent need in the pharmaceutical field. This review intends to offer the “state of the art” about the separation of chiral antifungal drugs and several related precursors by both liquid and gas chromatography, as well as electromigration methods. This overview is organized into two sections. The first one describes general considerations on chiral antifungal drugs. The second part deals with the main analytical methods for the enantiomeric discrimination of these drugs, including a brief description of chiral selectors and stationary phases. Moreover, many recent applications attesting the great interest of analytical chemists in the field of enantiomeric separation are presented.

scholarly journals Plumbagin-Loaded Glycerosome Gel as Topical Delivery System for Skin Cancer Therapy

Polymers ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 923
Author(s):  
Shadab Md ◽  
Nabil A. Alhakamy ◽  
Hibah M. Aldawsari ◽  
Mohammad Husain ◽  
Nazia Khan ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Zeta Potential ◽  
Skin Permeation ◽  
Entrapment Efficiency ◽  
Aqueous Solubility ◽  
Skin Layer ◽  
Vesicle Size ◽  
Cytotoxicity Activities

Plumbagin (PLM) is a phytochemical which has shown cytotoxicity against of cancer cells both in vitro and in vivo. However, the clinical application of PLM has been hindered due to poor aqueous solubility and low bioavailability. The aim of the present study was to develop, optimize and evaluate PLM-loaded glycerosome (GM) gel and compare with conventional liposome (CL) for therapeutic efficacy against skin cancer. The GM formulations were optimized by employing design expert software by 3-level 3-factor design. The prepared GMs were characterized in vitro for vesicle size, size distribution, zeta potential, vesicle deformability, drug release, skin permeation, retention, texture, antioxidant and cytotoxicity activities. The optimized formulation showed a vesicle size of 119.20 ± 15.67 nm with a polydispersity index (PDI) of 0.145 ± 0.02, the zeta potential of −27 ± 5.12 mV and entrapment efficiency of 76.42 ± 9.98%. The optimized PLM-loaded GM formulation was transformed into a pre-formed gel which was prepared using Carbopol 934 polymer. The drug diffusion fluxes of CL gel and GM-loaded gel were 23.31 ±6.0 and 79.43 ± 12.43 µg/ cm2/h, respectively. The result of texture analysis revealed the adequate hardness, cohesiveness, consistency, and viscosity of the developed GM-loaded gel compared to CL gel. The confocal images showed that glycerosomal gel has deeper skin layer penetration as compared to the control solution. GM-loaded gel treated rat skin showed significantly (p < 0.05) higher drug accumulation in the dermis, higher cytotoxicity and higher antioxidant activity as compared to CL gel and PLM suspension. Thus, findings revealed that novel GM-loaded gel could be potential carriers for therapeutic intervention in skin cancer.

Chiral discrimination between alanine enantiomers by field effect transistor with a homocysteine monolayer-modified gate

2010 ◽  
Vol 55 (15) ◽  
pp. 4501-4505 ◽  
Author(s):  
Mariko Matsunaga ◽  
Daisuke Yamamoto ◽  
Takuya Nakanishi ◽  
Tetsuya Osaka
Keyword(s):  
Field Effect ◽  
Field Effect Transistor ◽  
Chiral Discrimination ◽  
Effect Transistor

Chiral Resolution of Hexaamine Cobalt(III) Cages: Substituent Effects on Chiral Discrimination

2003 ◽  
Vol 56 (12) ◽  
pp. 1187 ◽  
Author(s):  
Paul V. Bernhardt ◽  
Tri Erny Dyahningtyas ◽  
Jack M. Harrowfield ◽  
Jee-Young Kim ◽  
Yang Kim ◽  
...  
Keyword(s):  
Complex Anion ◽  
Substituent Effects ◽  
Outer Sphere ◽  
Exchange Chromatography ◽  
Chiral Resolution ◽  
Chiral Discrimination ◽  
Pairing Interaction ◽  
X Ray ◽  
Selective Crystallization ◽  
Bonding Interaction

Chiral resolution of the cobalt cage complexes [Co(diNOsar)]3+ and [Co(diAMsarH2)]5+ have been achieved by selective crystallization with the anion bis-μ-(R), (R)-tartratodiantimonate(III) ([Sb2(R,R-tart)2]2–) and also by column chromatography with Na2[Sb2(R,R-tart)2] as eluent. The X-ray crystal structures of Λ-[Co(diNOsar)][Sb2(R,R-tart)2]Cl . 7 H2O and Δ-[Co(diAMsarH2)][Sb2(R,R-tart)2]2Cl . 14 H2O are reported, which reveal an unexpected reversal of chiral discrimination when the cage substituent is changed from nitro (Λ-enantiomer) to ammonio Δ-enantiomer) and shows that the ammonio-substituted cage is capable of forming a three-point hydrogen-bonding interaction with each complex anion, whereas the nitro analogue can only form two hydrogen bonds with each [Sb2(R,R-tart)2]2– anion. During cation exchange chromatography of the racemic cobalt cage complexes with Na2[Sb2(R,R-tart)2] as eluent, Λ-[Co(diNOsar)]3+ elutes first, which implies a tighter ion pairing interaction than for the Δ-enantiomer. On the other hand, Δ-[Co(diAMsarH2)]5+ elutes first during chromatography under identical conditions, which is also consistent with a preferred outer-sphere complex formed between Δ-[Co(diAMsarH2)]5+ and [Sb2(R,R-tart)2]2– relative to Λ-[Co(diAMsarH2)]5+ and [Sb2(R,R-tart)2]2–.

Chiral discrimination of Dns- and unmodified d,l-amino acids by copper(II) complexes of terdentate ligands in high-performance liquid chromatography

1998 ◽  
Vol 829 (1-2) ◽  
pp. 101-113 ◽  
Author(s):  
Gianni Galaverna ◽  
Roberto Corradini ◽  
Arnaldo Dossena ◽  
Emma Chiavaro ◽  
Rosangela Marchelli ◽  
...  
Keyword(s):  
Amino Acids ◽  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
Chiral Discrimination
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