scholarly journals Clinical, cellular and molecular effects of corticosteroids on the response to intradermal lipopolysaccharide administration in healthy volunteers

2021 ◽  
Author(s):  
Thomas P. Buters ◽  
Pieter Hameeteman ◽  
Iris M.E. Jansen ◽  
Floris C. van Hindevoort ◽  
Wouter ten Voorde ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Molecular Effects

scholarly journals Tolerability and Safety of a Nutritional Supplement with Potential as Adjuvant in Colorectal Cancer Therapy: A Randomized Trial in Healthy Volunteers

Nutrients ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 2001 ◽  
Author(s):  
Marta Gómez de Cedrón ◽  
José Moises Laparra ◽  
Viviana Loria-Kohen ◽  
Susana Molina ◽  
Juan Moreno-Rubio ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Healthy Volunteers ◽  
Immune Modulation ◽  
Mononuclear Cells ◽  
Ex Vivo ◽  
Study Groups ◽  
Nutritional Supplement ◽  
Double Blind ◽  
Peripheral Blood Mononuclear ◽  
Molecular Effects

Bioactive supplements display relevant therapeutic properties when properly applied according to validated molecular effects. Our previous research efforts established the basis to develop a dietary supplement based on a Rosmarinus officinalis supercritical extract. This was enriched in phenolic diterpenes (RE) with proven properties against signaling pathways involved in colon tumorigenesis, and shark liver oil rich in alkylglycerols (AKG) as a bioactive lipid vehicle to improve RE bioavailability and synergize with the potential therapeutic action of the extract. Herein, we have investigated the tolerability and safety of the supplement and the biological and molecular effects from an immuno-nutritional perspective. Sixty healthy volunteers participated in a six week, double-blind, randomized parallel pilot study with two study arms: RE-AKG capsules (CR) and control capsules (CC). Mean age (±SD) of volunteers was 28.32 (±11.39) and 27.5 (±9.04) for the control and the study groups, respectively. Safety of the CR product consumption was confirmed by analyzing liver profile, vital constants, and oxidation markers (LDLox in blood and isoprostanes and thromboxanes in urine). The following were monitored: (1) the phenotyping of plasmatic leukocytes and the ex vivo response of lipopolysaccharide (LPS)-stimulated peripheral blood mononuclear cells (PBMCs); (2) expression of genes associated with immune-modulation, inflammation, oxidative stress, lipid metabolism, and tumorigenesis; and (3) the correlation of selected genetic variants (SNPs) with the differential responses among individuals. The lack of adverse effects on liver profile and oxidation markers, together with adequate tolerability and safe immunological adaptations, provide high-quality information for the potential use of CR as co-adjuvant of therapeutic strategies against colorectal cancer.

Helicobacter pylori infection potentiates the inhibition of gastric acid secretion by omeprazole differently in duodenal ulcer patients and healthy volunteers

2001 ◽  
Vol 120 (5) ◽  
pp. A648-A648
Author(s):  
A THOMSON ◽  
R LASTIWKA ◽  
M KEELAN ◽  
S APPELMAN ◽  
L ZUK ◽  
...  
Keyword(s):  
Duodenal Ulcer ◽  
Helicobacter Pylori ◽  
Acid Secretion ◽  
Healthy Volunteers ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Helicobacter Pylori Infection

Stereoselective pharmacokinetics of S-salbutamol after administration of the racemate in healthy volunteers

1999 ◽  
Vol 13 (6) ◽  
pp. 1230 ◽  
Author(s):  
B Schmekel ◽  
I Rydberg ◽  
B Norlander ◽  
K.n Sjöswärd ◽  
J Ahlner ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Stereoselective Pharmacokinetics

Estimation of 15O PET in healthy volunteers with automated ROI analysis by FineSRT

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S673-S673
Author(s):  
Ryo Takeuchi ◽  
Keiichi Matsumoto ◽  
Setsu Sakamoto ◽  
Yuhji Nakamoto ◽  
Michio Senda
Keyword(s):  
Healthy Volunteers

QUASI-MOLECULAR EFFECTS IN ION-ATOM COLLISIONS AT ION ENERGIES IN THE HUNDRED-keV REGION

1979 ◽  
Vol 40 (C1) ◽  
pp. C1-246-C1-249
Author(s):  
E. G. Bøving ◽  
K. Edlund ◽  
G. Sørensen
Keyword(s):  
Ion Energies ◽  
Molecular Effects

Concentration time profiles of plasma pentosidine in healthy volunteers following a breakfast rich in advanced glycation end products

2009 ◽  
Vol 34 (03) ◽  
Author(s):  
G Faustmann ◽  
I Sundl ◽  
A Meinitzer ◽  
M Maritschnegg ◽  
B Tiran ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Advanced Glycation End Products ◽  
Advanced Glycation ◽  
Time Profiles ◽  
Concentration Time ◽  
Glycation End Products ◽  
End Products

Effects of green tea, black tea and rooibos on angiotensin-converting enzyme activity in healthy volunteers

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
IAL Persson ◽  
K Persson ◽  
S Hägg ◽  
RGG Andersson
Keyword(s):  
Enzyme Activity ◽  
Angiotensin Converting Enzyme ◽  
Healthy Volunteers ◽  
Green Tea ◽  
Black Tea ◽  
Converting Enzyme ◽  
Angiotensin Converting Enzyme Activity

Subregional amygdala functional connectivity: normative maps and influence of oral citalopram in healthy volunteers

2009 ◽  
Vol 42 (05) ◽  
Author(s):  
R Goya-Maldonado ◽  
VI Spoormaker ◽  
N Chechko ◽  
D Höhn ◽  
K Andrade ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Healthy Volunteers

Effects of oral methylphenidate on [18F]fallypride binding in healthy volunteers and adults with attention-deficit hyperactivity disorder (ADHD)

2009 ◽  
Vol 42 (05) ◽  
Author(s):  
N Del Campo ◽  
TD Fryer ◽  
YT Hong ◽  
D Izquierdo ◽  
R Smith ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Healthy Volunteers ◽  
Attention Deficit ◽  
Hyperactivity Disorder
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