Clinician's commentary: Atypical peritoneal cytology in ovarian and endometrial cancers

The aim of this study was to investigate the relationship between heparanase expression and prognostic factors in endometrial cancer, as well as the relationship between heparanase expression during phases of the normal endometrial cycle. Immunohistochemical analysis of 166 endometrial cancers and 34 normal endometria in various phases of growth was performed. The heparanase expression in the late-proliferative phase of normal endometria was found to be significantly higher than in either the early-proliferative or the secretory phases (P = .012 and P = .044, respectively). Heparanase expression was also significantly higher in endometrial cancer patients with tumors of an advanced FIGO stage (P = .0003) and high FIGO grade (P = .004) and with cancers showing either deep myometrial invasion (P = .023), lymph node metastasis (P = .006), lymphvascular space involvement (P = .048), or positive peritoneal cytology (P = .010). The disease-free and overall survival rates of patients with intense heparanase expression were significantly lower than those of patients with absent or moderate heparanase expression (P = .004 and P = .002, respectively). Heparanase may participate in normal endometrial remodeling and can serve as an indicator of the aggressive potential and poor prognosis of endometrial cancers.

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An audit of pathological and radiological correlation of myometrial invasion and histological features associated with lymph node metastasis in endometrial cancers

10.26226/morressier.578f37fad462b8028d88f9c3 ◽

2016 ◽

Author(s):

Thiagarajah Balamurugan

Keyword(s):

Lymph Node ◽

Lymph Node Metastasis ◽

Myometrial Invasion ◽

Histological Features ◽

Node Metastasis ◽

Endometrial Cancers

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Evaluation of Mismatch Repair (MMR) protein expression for lynch syndrome screening in endometrial cancers in Turkish women: A preliminary study

10.26226/morressier.596dfd56d462b80292387920 ◽

2017 ◽

Author(s):

Ipek Erbarut Seven

Keyword(s):

Lynch Syndrome ◽

Protein Expression ◽

Mismatch Repair ◽

Turkish Women ◽

Preliminary Study ◽

Endometrial Cancers

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THE SIGNIFICANCE OF PRE-OPERATIVE ENDOMETRIAL SAMPLING IN GRADE 1, LOW RISK ENDOMETRIAL CANCERS: IGCS-0088 Uterine Cancer, including Sarcoma

International Journal of Gynecological Cancer ◽

10.1136/00009577-201505001-00057 ◽

2015 ◽

Vol 25 (Supp 1) ◽

pp. 72-73

Author(s):

L. Singh ◽

T. Pua ◽

P. Khattar ◽

L. Han ◽

S. Tedjarati ◽

...

Keyword(s):

Uterine Cancer ◽

Low Risk ◽

Endometrial Sampling ◽

Endometrial Cancers

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Expression and function of ER-B in premenopausal endometrial cancers

Gynecologic Oncology ◽

10.1016/j.ygyno.2019.03.199 ◽

2019 ◽

Vol 154 (1) ◽

pp. e17-e18

Author(s):

Carlos A. De la Garza ◽

Philip T. Valente ◽

Kumaraguruparan Ramasamy ◽

Ajeshwar R. Tekmal ◽

Edward R. Kost

Keyword(s):

Endometrial Cancers ◽

And Function

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Prognostic significance of peritoneal cytology in low-risk endometrial cancer: comparison of laparoscopic surgery and laparotomy

International Journal of Clinical Oncology ◽

10.1007/s10147-020-01854-z ◽

2021 ◽

Author(s):

Satoe Fujiwara ◽

Ruri Nishie ◽

Shoko Ueda ◽

Syunsuke Miyamoto ◽

Shinichi Terada ◽

...

Keyword(s):

Endometrial Cancer ◽

Laparoscopic Surgery ◽

Retrospective Study ◽

Prognostic Significance ◽

Low Risk ◽

Peritoneal Cytology ◽

Chi Square ◽

Significant Difference ◽

Chi Square Test ◽

Positive Peritoneal Cytology

Abstract Background There is uncertainty surrounding the prognostic value of peritoneal cytology in low-risk endometrial cancer, especially in laparoscopic surgery. The objective of this retrospective study is to determine the prognostic significance of positive peritoneal cytology among patients with low-risk endometrial cancer and to compare it between laparoscopic surgery and conventional laparotomy. Methods From August 2008 to December 2019, all cases of pathologically confirmed stage IA grade 1 or 2 endometrial cancer were reviewed at Osaka Medical College. Statistical analyses used the Chi-square test and the Kaplan–Meier log rank. Results A total of 478 patients were identified: 438 with negative peritoneal cytology (232 who underwent laparotomy and 206 who undertook laparoscopic surgery) and 40 with positive peritoneal cytology (20 who underwent laparotomy and 20 who received laparoscopic surgery). Survival was significantly worse among patients with positive peritoneal cytology compared to patients with negative peritoneal cytology. However, there was no significant difference among patients with negative or positive peritoneal cytology between laparoscopic surgery and laparotomy. Conclusion This retrospective study suggests that, while peritoneal cytology is an independent risk factor in patients with low-risk endometrial cancer, laparoscopic surgery does not influence the survival outcome when compared to laparotomy.

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Tumor lysis syndrome in advanced and high-grade endometrial cancers: A case report and review of the literature

Gynecologic Oncology Reports ◽

10.1016/j.gore.2021.100761 ◽

2021 ◽

pp. 100761

Author(s):

Johnathan Zhao ◽

Heather Miller ◽

Erin A. Blake

Keyword(s):

Case Report ◽

Tumor Lysis Syndrome ◽

High Grade ◽

Review Of The Literature ◽

Tumor Lysis ◽

Endometrial Cancers

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Molecular Classification to Prognosticate Response in Medically Managed Endometrial Cancers and Endometrial Intraepithelial Neoplasia

Cancers ◽

10.3390/cancers13112847 ◽

2021 ◽

Vol 13 (11) ◽

pp. 2847

Author(s):

Allison M. Puechl ◽

Daniel Spinosa ◽

Andrew Berchuck ◽

Angeles Alvarez Secord ◽

Kerry E. Drury ◽

...

Keyword(s):

Endometrial Cancer ◽

Single Gene ◽

Intraepithelial Neoplasia ◽

Molecular Classification ◽

Definitive Treatment ◽

Time To Progression ◽

Endometrial Intraepithelial Neoplasia ◽

Definitive Therapy ◽

Patients At Risk ◽

Endometrial Cancers

Background: The aim of this study was to evaluate whether molecular classification prognosticates treatment response in women with endometrial cancers and endometrial intraepithelial neoplasia (EIN) treated with levonorgestrel intrauterine system (LNG-IUS). Methods: Patients treated with LNG-IUS for endometrial cancer or EIN from 2013 to 2018 were evaluated. Using immunohistochemistry and single gene sequencing of POLE, patients were classified into four groups as per the Proactive Molecular Risk Classifier for Endometrial cancer (ProMisE): POLE-mutated, mismatch repair-deficient (MMRd), p53 wild type (p53wt), and p53-abnormal (p53abn). Groups were assessed relative to the primary outcome of progression or receipt of definitive treatment. Results: Fifty-eight subjects with endometrioid endometrial cancer or EIN treated with LNG-IUS were included. Of these, 22 subjects (37.9%) had endometrial cancer and 36 subjects (62.1%) had EIN. Per the ProMisE algorithm, 44 patients (75.9%) were classified as p53wt, 6 (10.3%) as MMRd, 4 (6.9%) as p53abn, and 4 (6.9%) as POLE-mutated. Of the 58 patients, 11 (19.0%) progressed or opted for definitive therapy. Median time to progression or definitive therapy was 7.5 months, with p53abn tumors having the shortest time to progression or definitive therapy. Conclusions: Molecular classification of endometrial cancer and EIN prior to management with LNG-IUS is feasible and may predict patients at risk of progression.

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