Synthesis, characterization, method development, and validation of nor‐ethylmorphine hydrochloride reference material using established analytical techniques for dope control analysis

2021 ◽  
Author(s):  
Sachin Dattram Pawar ◽  
Gangasani Jagadeesh Kumar ◽  
Aruna Chikkondra ◽  
Banwari Lal ◽  
P. Radhakrishnanand ◽  
...  
Keyword(s):  
Reference Material ◽  
Method Development ◽  
Analytical Techniques ◽  
Control Analysis ◽  
Method Development And Validation ◽  
Development And Validation

scholarly journals ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF COMBINATION OF ANTI-ASTHMATIC DRUGS MONTELUKAST AND DOXOFYLLINE

2021 ◽  
Vol 11 (6) ◽  
pp. 86-91
Author(s):  
Sachin N. Kapase
Keyword(s):  
Liquid Chromatography ◽  
High Performance ◽  
Method Development ◽  
Analytical Techniques ◽  
Ultra Performance Liquid Chromatography ◽  
Hplc Method ◽  
Uv Spectrophotometry ◽  
Method Development And Validation ◽  
Development And Validation ◽  
Layer Chromatography

For qualitative and quantitative analysis, various analytical techniques are available such as Ultraviolet (UV) Spectrophotometry, High-performance liquid chromatography (HPLC), High-performance thin layer chromatography (HPTLC). As per literature survey, there are some UV, HPLC, Ultra-Performance Liquid Chromatography (UPLC) and HPTLC analytical methods are developed for Montelukast and Doxofylline individually and in a combination with other drugs too, since yet there are no significant stability studies indicating HPLC method reported for Montelukast and Doxofylline combinations. In the current study, the HPLC method is developed and validated for simultaneous quantitative estimations of Montelukast and Doxofylline. These present techniques are more efficient and sensitive as compared to other analytical techniques.

scholarly journals A Review on: Analytical Techniques Development and Validation of Drugs Used for Alzheimer’s Disease

2021 ◽  
pp. 228-243
Author(s):  
Sunayana Kesharwani ◽  
Parul Mehta
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Liquid Chromatography ◽  
Method Development ◽  
Neurodegenerative Disorder ◽  
Analytical Techniques ◽  
Long Term Treatment ◽  
Method Development And Validation ◽  
Pharmaceutical Industries ◽  
Development And Validation

Pharmaceutical analysis plays a very prominent role in quality assurance as well as quality control of bulk drugs and pharmaceutical formulations. Rapid increase in pharmaceutical industries and production of drug in various parts of the world has brought a rise in demand for new analytical techniques in the pharmaceutical industries. As a consequence, analytical method development has become the basic activity of analysis. Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive memory defeat and impairment in behavior, language and visuospatial skills. Donepezil, rivastigmine, galantamine, tacrine and memantine are the US Food and Drug Administration approved oral drugs used in the treatment of AD. These drugs can provide a symptomatic relief but they poorly affect the progression of the disease. Quantization of these drugs in various biological matrices, dosage forms and monitoring them in long-term treatment is essential to titer the dose of these drugs and ensures patient compliance. The main objective of this review mainly focused on spectrophotometric, high-performance liquid chromatography (HPLC), HPTLC and liquid chromatography-mass spectroscopy (LC-MS) which can be used for method development and validation of different Alzheimer’s drugs. The review is a collection of data including various analytical methods used, the different columns used, mobile phase used, flow rate, different detectors and detection wavelength and retention time. This review includes discussion on method development and validation of Alzheimer’s drugs and newly developed compounds which have lesser side effects and are proving more efficient for treatment of Alzheimer’s disease. This review challenges to researches for development of front line drug for Alzheimer’s disease.

scholarly journals Analytical method development and validation of Secnidazole in the tablet dosage form by RP-HPLC method

2016 ◽  
Vol 5 (4) ◽  
pp. 41-44
Author(s):  
Tanzina Sharmin ◽  
Mariyam Akter ◽  
Mohammad Salim Hossain
Keyword(s):  
Method Development ◽  
Cost Effective ◽  
Pharmaceutical Journal ◽  
Hplc Method ◽  
Control Analysis ◽  
Inexpensive Method ◽  
Phase Signal ◽  
Method Development And Validation ◽  
Development And Validation ◽  
Tablet Dosage

Objective of the present work is to develop and validate a simple, cost effective, sensitive and fast HPLC method for the analysis of Secnidazole. A Shimadzu HPLC system with Luna 5µm C18 column is employed for the analysis using Methanol:H2O (60:40, v/v) as mobile phase. Signal from Secnidazole is detected at 310nm by UV Spectrophotometer. The proposed method is fully validated and found to be linear over a workable drug concentration, accurate, precise and robust. This fast and inexpensive method is suitable for research laboratories as well as for quality control analysis in pharmaceutical industries.Sharmin et al., International Current Pharmaceutical Journal, March 2016, 5(4): 41-44http://www.icpjonline.com/documents/Vol5Issue4/03.pdf

METHOD DEVELOPMENT AND VALIDATION OF LENVATINIB BY HPLC AND UV-SPECTROSCOPY

INDIAN DRUGS ◽  
2018 ◽  
Vol 55 (04) ◽  
pp. 39-47
Author(s):  
R. S. M Patve ◽  
◽  
A. R. Shaikh ◽  
N Inamdar ◽  
K. Bhise
Keyword(s):  
Method Development ◽  
Orthophosphoric Acid ◽  
Ammonium Acetate ◽  
Uv Spectroscopy ◽  
Hplc Method ◽  
Control Analysis ◽  
Quality Control Analysis ◽  
Method Development And Validation ◽  
Development And Validation

A simple rapid, accurate, precise and reproducible validated UV spectroscopy, RP-HPLC method was were developed for the determination of lenvatinib in bulk forms. The quantification was carried out using HiQSil 4.6 X 250 mm, 5μ, C8 column, run in isocratic way using mobile phase comprising of methanol: ammonium acetate buffer 30:70 by volume, pH-3.5 adjusted with orthophosphoric acid and a detection wavelength of 301mm, and injection volume of 20μL, with a flow rate of 1.0mL/min. The retention time of lenvatinib was found to be 4.383 min., the linearity range of the proposed method lies between 10-40 μg/mL (r²=0.9992). recovery studies were also carried out and mean % recovery was found to be 99.05 for lenvatinib. LOD and LOQ values for lenvatinib were found to be 0.992 and 2.79 respectively. The proposed method was statistically evaluated and may be applied for routine quality control analysis of lenvatinib in bulk.

Method Development and Validation of Hydrochlorothiazide and Quinapril in bulk and tablet dosage form by RP-HPLC

2014 ◽  
Vol 1 (1) ◽  
pp. 10
Author(s):  
Harini Kanchukommula ◽  
Ananda Thangadurai Subramaniam ◽  
Jambulingam Munusamy ◽  
Kamalakannan Danapal ◽  
Saravanakumar Sengodan
Keyword(s):  
Method Development ◽  
Pharmaceutical Formulations ◽  
Control Analysis ◽  
Bulk Powder ◽  
Quality Control Analysis ◽  
Rp Hplc ◽  
Method Development And Validation ◽  
Development And Validation ◽  
Tablet Dosage

A RPHPLC chromatographic method was developed and validated for the determination of Quinapril and Hydrochlorothiazide in bulk powder and in pharmaceutical formulations. Quinapril and Hydrochlorothiazide can be separated on Zorbax Eclipse XDB, C18 column (150 x 4.6 mm, 5 mm) at 30 C using Acetonitrile: Phosphate buffer, pH 4.5 was adjusted with o-phosphoric acid in the ratio of 35:65 v/v as a mobile phase at flow rate of 0.9 mL min-1 and detected at 210 nm. The retention time of Quinapril and Hydrochlorthiazide was found to be 2.099 min and 5.537 min respectively. The validation of the proposed method was carried out for specificity, linearity, accuracy, precision, LOD, LOQ and robustness. Calibration was linear over a range of 50-300 g mL-1 and 31.25187.5 g mL-1 with correlation coefficient of 0.999 for Quinapril and Hydrochlorthiazide, respectively. The robustness of the method was evaluated by deliberately altering the chromatographic conditions. The method developed can be applicable for quality control analysis.

scholarly journals Modern Trends in Analytical Techniques for Method Development and Validation of Pharmaceuticals: A Review

2021 ◽  
Vol 11 (1-s) ◽  
pp. 121-130
Author(s):  
Shivani Sharma ◽  
Navdeep Singh ◽  
Amar Deep Ankalgi ◽  
Arti Rana ◽  
Mahendra Singh Ashawat
Keyword(s):  
Analytical Chemistry ◽  
Drug Development ◽  
Development Process ◽  
Method Development ◽  
Limit Of Detection ◽  
Analytical Techniques ◽  
Review Article ◽  
Modern Trend ◽  
Method Development And Validation ◽  
Development And Validation

The process of drug development requires a suitable technique which helps the scientist to analyze the drug molecule is an accurate, precise, and easiest way. For the quantitative and qualitative estimation of drugs in analytical chemistry it is very important to identify the best method for method development.  This study helps the author to understand the various analytical techniques available for the process of drug development which includes spectroscopy, chromatography, electrochemical techniques, electrophoretic, flow injection analysis, and hyphenated technique. All these methods contain different analytical process with a variety of separate techniques. Also, we discuss about the modern trend which are available, and implacable in all these methods to improve the analytical behavior of these techniques. In method development process the validation of document must be required in the form of accuracy, precision, specificity, limit of detection, linearity, and range is considered. So, this review article contains the brief summary of available analytical techniques, and the latest trend in method development, or the process of method validation, and development of method. The discussed methods in this review article were revealed by the scientist, and these techniques must require in new drug development process, which helps the person to utilize the potential of these techniques. Trend in the analytical chemistry to overcome the error in method development was necessary, and the latest trends in method development technique were useful to defeat errors in analytical techniques. Keywords: Analytical techniques, Modern trends, Process of method development, and validation.

A Review on Analytical Methods of Irbesartan and its Combinations in Pharmaceutical Dosage Forms

2020 ◽  
Vol 16 (8) ◽  
pp. 1020-1029 ◽  
Author(s):  
Calamur Nagarajan Nalini ◽  
Nivedhitha Mathivanan
Keyword(s):  
Method Development ◽  
Analytical Techniques ◽  
Dosage Forms ◽  
Angiotensin Ii Receptor Blocker ◽  
Uv Spectrophotometry ◽  
Angiotensin Ii Receptor ◽  
Research Activity ◽  
Pharmaceutical Dosage Forms ◽  
Method Development And Validation ◽  
Development And Validation

Pharmaceutical analysis plays an indispensable role in various stages of drug pipeline including drug development, fabrication of formulation, stability studies and quality control. It is also used for characterizing the composition of different dosage forms in quantitative and qualitative ways. Comprehensive literature survey forms the foundation stone for the focused analysis of research activity. Irbesartan is a hypertension antagonist chiefly employed in the treatment of high blood pressure which is an Angiotensin II Receptor blocker. The multiple mixtures of various antihypertensive medicaments raise challenges in the method development and validation. A genuine venture is undertaken to compile the literatures related to the antihypertensive drug Irbesartan published in various peer reviewed journals. HPLC and UV spectrophotometry are the most preferred analytical techniques when compared to other methods. This present review provides an in-depth assortment of various analytical techniques published for Irbesartan and its combinations, which will help the researchers in their future endeavors.

Iridoid analysis by different analytical techniques and its role as pharmacologic agents- A review

2021 ◽  
Vol 18 ◽  
Author(s):  
Rishabh Verma ◽  
M. Faiz Arshad ◽  
Parul Grover ◽  
Jasmeet Kaur ◽  
Neha Gandhi ◽  
...  
Keyword(s):  
Method Development ◽  
Iridoid Glycosides ◽  
Analytical Techniques ◽  
Therapeutic Effects ◽  
Protective Effects ◽  
Dicotyledonous Plants ◽  
Method Development And Validation ◽  
Development And Validation ◽  
Pharmacologic Agents

Abstract: Iridoids are monoterpenoids classed with a cyclopentanopyran framework and are detected in various plants and certain special animals. In plants, it exists as glycosides, generally bound to glucose. Around six hundred iridoid glycosides are available in fifty-seven families of plants. Iridoids are abundant in dicotyledonous plants belonging to the Diervillaceae, Loganiaceae, Apocynaceae, Scrophulariaceae, Lamiaceae, and Rubiaceae families. Analytical techniques like chromatography, NMR, UPLC, etc., are used for the identification, separation, and estimation of either herbal extracts or formulations of iridoids. Advanced analytical techniques are very useful for precise and accurate quantification of active ingredients that are responsible for therapeutic effects, and they can be achieved by a developed and validated robust analytical method. Iridoids have shown diverse pharmacological properties. Some of the important activities are immunomodulatory, neuroprotective, anti-inflammatory, hepatoprotective, and cardio-protective effects. The other important activities are antimicrobial, antioxidant, hypoglycemic, hypolipidemic, anticancer, choleretic, antispasmodic, and purgative activities attributed to iridoids. There were not many efforts made in the past to gather and review the literature on various aspects of iridoids. This review article has collected a myriad of literature on old and advanced analytical techniques, including method development and validation of methods for quantitative and qualitative analysis of iridoids. The review also emphasizes the role of iridoids in the prevention of various ailments.

scholarly journals UV SPECTROPHOTOMETRY METHOD DEVELOPMENT AND VALIDATION OF SULFADIAZINE AND TRIMETHOPRIM IN COMBINED DOSAGE FORM

2018 ◽  
Vol 10 (1) ◽  
pp. 103
Author(s):  
Ramakrishna Veni Pokala ◽  
Kusuma Kumari ◽  
Hari Babu Bollikola
Keyword(s):  
Present Method ◽  
Method Development ◽  
Rapid Determination ◽  
Uv Spectrophotometry ◽  
Control Analysis ◽  
Quality Control Analysis ◽  
Double Beam ◽  
Method Development And Validation ◽  
Development And Validation

Objective: A new, simple, sensitive and economical UV spectrophotometric method was developed for the simultaneous analysis of Sulfadiazine [SDA] and Trimethoprim [TMP] in pharmaceutical formulations.Methods: This UV method was developed with methanol as solvent. The wavelengths selected for analysis in the present method were 265 nm for TMP and 289 nm for SDA. Teccomp UV-2301 double beam UV/Vis spectrophotometer was used to carry out spectral analysis and the data was recorded by Hitachi software.Results: Linearity was found to be within the concentration range of 2-9 µg/ml TMP and 9.08-41 µg/ml of SDA. Accuracy of the method was determined by recovery studies. Percentage recovery was found to be 98.20-99.25 for TMP with a % RSD of 0.338, 0.506 and 0.510 for three spiked levels. % RSD was found to be 0.229 and 0.380; 0.212 and 0.328 for SDA, TMP in intra and inter-day precision respectively. The % RSD value in ruggedness was found to be 0.440 for SDA and 0.569 for TMP.Conclusion: The advantages of this method for analytical purposes lie in the rapid determination, its cost-effectiveness, easy preparation of the sample, good reproducibility. In addition to this, the present method can be recommended for simultaneous determination of SDA and TMP in routine quality control analysis in combined drug formulations.

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