scholarly journals Hypoglycemic effect of Taraxacum officinale root extract and its synergism with Radix Astragali extract

2021 ◽  
Author(s):  
Jingwen Li ◽  
Jiayuan Luo ◽  
Yangyang Chai ◽  
Yang Guo ◽  
Yang Tianzhi ◽  
...  
Keyword(s):  
Taraxacum Officinale ◽  
Hypoglycemic Effect ◽  
Root Extract ◽  
Radix Astragali

scholarly journals Protective Effects of Taraxacum officinale L. (Dandelion) Root Extract in Experimental Acute on Chronic Liver Failure

Antioxidants ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 504
Author(s):  
Iulia Olimpia Pfingstgraf ◽  
Marian Taulescu ◽  
Raluca Maria Pop ◽  
Remus Orăsan ◽  
Laurian Vlase ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Failure ◽  
Tissue Injury ◽  
Taraxacum Officinale ◽  
Chronic Liver ◽  
Root Extract ◽  
Protective Effects ◽  
Stress Tests ◽  
Chronic Liver Failure

Background: Taraxacum officinale (TO) or dandelion has been frequently used to prevent or treat different liver diseases because of its rich composition in phytochemicals with demonstrated effect against hepatic injuries. This study aimed to investigate the possible preventing effect of ethanolic TO root extract (TOERE) on a rat experimental acute on chronic liver failure (ACLF) model. Methods: Chronic liver failure (CLF) was induced by human serum albumin, and ACLF was induced in CLF by D-galactosamine and lipopolysaccharide (D-Gal-LPS). Five groups (n = 5) of male Wistar rats (200–250 g) were used: ACLF, ACLF-silymarin (200 mg/kg b.w./day), three ACLF-TO administered in three doses (200 mg, 100 mg, 50 mg/kg b.w./day). Results: The in vivo results showed that treatment with TOERE administered in three chosen doses before ACLF induction reduced serum liver injury markers (AST, ALT, ALP, GGT, total bilirubin), renal tests (creatinine, urea), and oxidative stress tests (TOS, OSI, MDA, NO, 3NT). Histopathologically, TOERE diminished the level of liver tissue injury and 3NT immunoexpression. Conclusions: This paper indicated oxidative stress reduction as possible mechanisms for the hepatoprotective effect of TOERE in ACLF and provided evidence for the preventive treatment.

scholarly journals Traditional Chinese Herbal, “Dandelion” and Its Applications on Skin-Care

2021 ◽  
Author(s):  
Siukan Law ◽  
Chuiman Lo ◽  
Jie Han ◽  
Albert Wingnang Leung ◽  
Chuanshan Xu
Keyword(s):  
Preparation Method ◽  
Taraxacum Officinale ◽  
Root Extract ◽  
Pharmacological Properties ◽  
Chinese Herbal ◽  
Simple Preparation ◽  
Medicinal Value ◽  
Wide Range ◽  
Long Time ◽  
Low Toxicity

Dandelion (Taraxacum officinale) belongs to the Asteraceae or sunflower family. Its leaves, stems, and roots have been used in traditional Chinese herbal for a long time because dandelion has a wide range of pharmacological properties including anti-microbial, anti-viral, anti-inflammatory, and anti-infectious as well as anti-oxidation especially in the dandelion root extract which is the most medicinal value. A clinical study of dandelion extracts on skin acne and a simple preparation method of the dandelion extract would be discussed since the dandelion extract has low toxicity on the skin, even is non-toxic based on the British Herbal Pharmacopoeia recommendation. 

scholarly journals Hypoglycemic effect of Berberis microphylla G Forst root extract

2017 ◽  
Vol 16 (9) ◽  
pp. 2179 ◽  
Author(s):  
María C. Furrianca ◽  
Marysol Alvear ◽  
Tomás Zambrano ◽  
Víctor Fajardo ◽  
Luis A. Salazar
Keyword(s):  
Hypoglycemic Effect ◽  
Root Extract

scholarly journals Effect of Taraxacum officinale extract on PI3K/Akt pathway in DMBA-induced breast cancer in albino rats

2018 ◽  
Vol 38 (6) ◽  
Author(s):  
Mohamed Abdo Nassan ◽  
Mohamed Mohamed Soliman ◽  
Shimaa Ahmed Ismail ◽  
Samir El-Shazly
Keyword(s):  
Breast Cancer ◽  
Mammary Gland ◽  
Breast Cancer Incidence ◽  
Serum Levels ◽  
Taraxacum Officinale ◽  
Pcr Analysis ◽  
Albino Rats ◽  
Root Extract ◽  
Breast Cancer Growth ◽  
Excessive Proliferation

Background: Breast cancer is one of the most prevalent types of cancer and a leading cause of death in women. Materials and methods: An experimental model of breast cancer was induced in female albino rats using single intragastric dose of 7, 12 dimethylbenz (α) anthracene (DMBA) in sesame oil (50 mg/kg b.wt). Four months after DMBA administration, incidence of breast cancer was confirmed by measuring cancer antigen 15-3 (CA15-3) serum levels. Taraxacum officinale ssp. officinale root extract (TOE) was administered in a dose of 500 mg/kg by oral gavage for 4 weeks after breast cancer incidence. Level of CA15-3 as one of the best known breast tumor markers was elevated in all positive breast cancer rats. The genetic effects of TOE on Pdk1–Akt1–Pik3r1–Map3k1–Erbb2–PIk3ca using semi-quantitative RT-PCR analysis were evaluated. In parallel, histopathological changes and immunohistochemical expression of Bcl2 in mammary gland tissues were examined. Results: Level of CA15-3 was normalized in DMBA group administered TOE for 4 weeks. Administration of DMBA increased expression of Pdk1, Akt1, Pik3r1, Map3k1, Erbb2 and PIk3ca. Treatment with TOE normalized the up-regulated mRNA for all examined genes except Pik3ra that was up-regulated. Mammary gland tissues of DMBA group showed excessive proliferation of lining epithelium of acini and ductules with hyperchromatic nuclei with excessive immunostaining of Bcl2 in the proliferated epithelium that was ameliorated by TOE administration. In conclusion, TOE regulated PI3K and Akt pathways involved in suppression of breast cancer growth and proliferation. TOE is effective as anticancer herbal agent.

scholarly journals Inhibitory effect of Taraxacum officinale L (Compositae) aqueous root extract on spermatogenesis

2017 ◽  
Vol 16 (1) ◽  
pp. 109
Author(s):  
Lubna H. Tahtamouni ◽  
Reem N. Abdellatif ◽  
Rema A. Al-Khateeb ◽  
Zainab A. Al-Mazaydeh ◽  
Salem R. Yasin ◽  
...  
Keyword(s):  
Taraxacum Officinale ◽  
Inhibitory Effect ◽  
Root Extract ◽  
Aqueous Root Extract

scholarly journals Dandelion Root Extract Affects the Proliferation, Survival and Migration of Cervical Cancer Cell Lines

2021 ◽  
Author(s):  
Raúl Fernando VENEZUELA ◽  
Jessica Paola MOSMANN ◽  
María Laura MUGAS ◽  
Ana Ximena KIGUEN ◽  
Susana Carolina NUÑEZ MONTOYA ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cell Migration ◽  
Cell Lines ◽  
Cancer Cell ◽  
Biological Activities ◽  
Taraxacum Officinale ◽  
Cancer Cell Lines ◽  
Cervical Cancer Cell ◽  
Root Extract ◽  
And Migration

Abstract Background Taraxacum officinale has been shown to exert diverse biological activities, in someones cancer cell lines. Also in traditional medicine have been its used fresh latex to treat warts (non-malignant HPV infection); however, its effect over cervical cancer cell lines is yet to be explored. The aim was to evaluate the effects of a root extract of Taraxacum officinale on the proliferation, survival and migration of cervical cancer cell lines. Methods Ethanolic extract was obtained from T. officinale roots (R-EtOH). Caski (HPV16), HeLa (HPV18), C33A (HPV-) cervical cancer cell lines (CC) and keratinocytes HaCaT (HPV-) were used. Viability and inhibitory concentration values were determined by the MTT assay. Clonogenic assay was used to evaluate the survival. Effect on cell migration was evaluated by wound healing assay. Apoptotic response was observed using the TUNEL and Annexin V/7AAD assay. Results R-EtOH extract showed a dose-dependent cytotoxic effect on all cell lines. The number and size of the colonies, mainly in CC, decrease with higher concentrations of extract. R-EtOH effectively inhibits cell migration, and causes a higher percentage of apoptotic cells. Conclusion This study reports, for the first time, the antitumor potential of dandelion root extract (R-EtOH) on CC. Our results showed that R-EtOH affect proliferation, survival and cell migration. In addition, R-EtOH leads to apoptosis in all CC cells; thus, it is a promising extract for future studies which will allow to evaluate its usefulness in cervical cancer treatment as in other cancer types.

scholarly journals Hepatoprotective Effects of Taraxacum officinale Root Extract on Permethrin-induced Liver Toxicity in Adult Mice

2020 ◽  
Author(s):  
Fatma Ghorbel Koubaa ◽  
Mariem Chaâbane ◽  
Bochra Choura ◽  
Mouna Turki ◽  
Fatma Makni-Ayadi ◽  
...  
Keyword(s):  
Liver Injury ◽  
Liver Toxicity ◽  
Taraxacum Officinale ◽  
Negative Control ◽  
Control Group ◽  
Root Extract ◽  
Indoor Environments ◽  
Protective Effects ◽  
Sod Activity ◽  
Adult Mice

Background: Globally, permethrin is used as an insecticide for pest control in indoor environments and in agriculture to enhance food production by eradicating undesirable insects and controlling disease vectors.  Objective: The present study investigated the protective effects of Taraxacum officinale (dandelion) on permethrin-induced liver injury in mice.  Methods: Adult mice were divided into four groups. The first group was the negative control group, whereas the second group was the positive control group that received dandelion through the diet at 2% (corresponding to a dose of 5 g/kg bw). The third group received permethrin (96 mg/kg bw) by gavage, whereas the fourth group received permethrin and a diet enriched with dandelion (cotreatment). All mice were sacrificed after 14 days of treatment. Results: Biomarkers of liver toxicity (AST, ALT, ALP, and LDH activities and bilirubin level) increased following permethrin treatment. Permethrin induced oxidative stress, which was indicated by an increase in MDA and GSH levels as well as GPx activity and a decrease in SOD activity. Permethrin treatment caused histological alterations in the liver, whereas co-treatment with dandelion reduced liver injury. Our results revealed that alterations of biochemical parameters and liver histological profile in mice following permethrin exposure were reversed towards normalization by the treatment with dandelion roots extract.  Conclusion: The protective effect of this plant might be due to its antioxidant capacity.

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