scholarly journals HIGH ADIPOSE TISSUE DENSITY IS A NEGATIVE PROGNOSTIC FACTOR IN DLBCL PATIENTS TREATED BY R‐CHOP, INDEPENDENT FROM TMTV AND PS –FROM THE REMARC STUDY

2021 ◽  
Vol 39 (S2) ◽  
Author(s):  
J.‐F. Deux ◽  
M. Meignan ◽  
L. Chartier ◽  
A. Judet ◽  
L. Vercellino ◽  
...  

2020 ◽  
Vol 59 (12) ◽  
pp. 1488-1495 ◽  
Author(s):  
N. D. Kapoor ◽  
P. K. Twining ◽  
O. Q. Groot ◽  
B. J. Pielkenrood ◽  
M. E. R. Bongers ◽  
...  


2021 ◽  
Vol 10 (11) ◽  
pp. 2339
Author(s):  
Miyuki Kuroiwa ◽  
Sayuri Hamaoka-Fuse ◽  
Masahiro Sugimoto ◽  
Yuko Kurosawa ◽  
Yasuko Aita ◽  
...  

This study examined the relationship between plasma amino acid (AA) concentrations, including branched-chain AAs, and brown adipose tissue density (BAT-d). One hundred and seventy-three subjects (69 men, 104 women) aged 22–68 years were recruited during the winter season. AAs were comprehensively quantified using liquid chromatography-time-of-flight-mass spectrometry. The total hemoglobin concentration in the supraclavicular region ([total-Hb]sup), an indicator of BAT-d, was assessed using near-infrared time-resolved spectroscopy. Anthropometric parameters, including age, percentage of body fat, and visceral fat, were evaluated. Factors associated with higher (≥74 µM) or lower (<74 µM) [total-Hb]sup were investigated by multiple logistic regression models that included AA concentrations alone (model 1) or AA concentrations and anthropometric parameters (model 2) as independent variables. When adjusted for the false discovery rate, [total-Hb]sup was positively correlated with glycine and asparagine levels in men and with the serine level in both men and women and was negatively correlated with the branched-chain AA concentration in men. Models 1 and 2 correlated with higher or lower BAT-d for men (r = 0.73, p = 0.015) and women (r = 0.58, p = 0.079) and for men (r = 0.82, p = 0.0070) and women (r = 0.70, p = 0.020), respectively. A combination of anthropometric parameters and plasma AA concentrations could be a reliable biomarker for higher and lower BAT-d.



2011 ◽  
Vol 104 (10) ◽  
pp. 1641-1648 ◽  
Author(s):  
T Bauernhofer ◽  
M Pichler ◽  
E Wieckowski ◽  
J Stanson ◽  
A Aigelsreiter ◽  
...  




2020 ◽  
Vol 19 ◽  
pp. 153303382095700 ◽  
Author(s):  
Kunpeng Du ◽  
Qian Huang ◽  
Junguo Bu ◽  
Jieling Zhou ◽  
Zijian Huang ◽  
...  

Background: Circulating tumor cells (CTCs) hold huge potential for both clinical applications and basic research into the management of cancer, but the relationship between CTC count and cervical cancer prognosis remains unclear. Therefore, research on this topic is urgently required. Objective: This study investigated whether CTCs were detectable in patients with cervical cancer and whether CTC count was an indicator of prognosis. Methods: We enrolled 107 patients with pathologically confirmed cervical cancer. CTCs were detected after radiotherapy or concurrent cisplatin-containing chemotherapy in all patients. We evaluated all medical records and imaging data as well as follow-up information to calculate progression-free survival (PFS). PFS was defined as the time until first diagnosis of tumor progression or death. We also analyzed the relationship between CTC count and patient age, disease stage, histological differentiation, tumor size, and pathological type. Results: CTCs were identified in 86 of 107 patients (80%), and the CTC count ranged from 0 to 27 cells in 3.2 mL blood. The median progression-free survival (PFS) was 43.1 months. Patients in which CTCs were detected had a significantly shorter PFS than CTC-negative patients (P = 0.018). Multivariate analysis indicated that CTC count was an independent negative prognostic factor for survival. However, no correlation was observed between CTC count and patient age, disease stage, histological differentiation, tumor size, and pathological type. Conclusion: CTC count is an independent negative prognostic factor for cervical cancer.





2018 ◽  
Vol 23 (06) ◽  
pp. 1 ◽  
Author(s):  
Sayuri Fuse ◽  
Shinsuke Nirengi ◽  
Shiho Amagasa ◽  
Toshiyuki Homma ◽  
Ryotaro Kime ◽  
...  


Author(s):  
Mancin Stefano ◽  
Bertone Andrea ◽  
Cattani Daniela ◽  
Morenghi Emanuela ◽  
Passadori Lorena ◽  
...  


PLoS ONE ◽  
2013 ◽  
Vol 8 (3) ◽  
pp. e58069 ◽  
Author(s):  
Li Tian ◽  
Yang Zhang ◽  
Yu Chen ◽  
Min Cai ◽  
Hailong Dong ◽  
...  


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