Implementing Systems Engineering in Early Stage Research and Development (ESR&D) Engineering Projects

2020 ◽  
Vol 30 (1) ◽  
pp. 433-448
Author(s):  
Heidi Ann Hahn ◽  
Nick Lombardo ◽  
Ann Hodges ◽  
Mitchell Kerman ◽  
Frédéric Autran
Insight ◽  
2021 ◽  
Vol 24 (3) ◽  
pp. 8-14
Author(s):  
Michael DiMario ◽  
Gary Mastin ◽  
Heidi Hahn ◽  
Ann Hodges ◽  
Nick Lombardo

Author(s):  
Gábor Bergmann

AbstractStudying large-scale collaborative systems engineering projects across teams with differing intellectual property clearances, or healthcare solutions where sensitive patient data needs to be partially shared, or similar multi-user information systems over databases, all boils down to a common mathematical framework. Updateable views (lenses) and more generally bidirectional transformations are abstractions to study the challenge of exchanging information between participants with different read access privileges. The view provided to each participant must be different due to access control or other limitations, yet also consistent in a certain sense, to enable collaboration towards common goals. A collaboration system must apply bidirectional synchronization to ensure that after a participant modifies their view, the views of other participants are updated so that they are consistent again. While bidirectional transformations (synchronizations) have been extensively studied, there are new challenges that are unique to the multidirectional case. If complex consistency constraints have to be maintained, synchronizations that work fine in isolation may not compose well. We demonstrate and characterize a failure mode of the emergent behaviour, where a consistency restoration mechanism undoes the work of other participants. On the other end of the spectrum, we study the case where synchronizations work especially well together: we characterize very well-behaved multidirectional transformations, a non-trivial generalization from the bidirectional case. For the former challenge, we introduce a novel concept of controllability, while for the latter one, we propose a novel formal notion of faithful decomposition. Additionally, the paper proposes several novel properties of multidirectional transformations.


1987 ◽  
Vol 2 (3) ◽  
pp. 114-118
Author(s):  
M.W. Dale

This paper presents a manufacturing systems engineering view of important issues relating to IT research and development. It argues for an approach to the next phase of information technology development which is heavily based on real-world applications with the dominant influences held by educated users and engineers who have added computing skills, rather than information technologists. It argues for ‘consolidation’ with particular attention to total systems integration and an emphasis on the need to professionally engineer the human interface.


2020 ◽  
Vol 8 (2) ◽  
pp. 86
Author(s):  
Zulbahri Zulbahri ◽  
Yuni Astuti ◽  
Erianti . ◽  
Pitnawati . ◽  
Damrah .

This research is motivated by the limited development of learning media for the subjects of Physical Education, Sports and Health on floor exercise (artistic) material, especially for schools in the regions. This study aims to produce a learning media product for students and students in learning gymnastics. The subjects or samples of this research were FIK UNP students who attended basic and advanced / learning gymnastics courses with a total of 12 people for small group subject trials and 15 people for field trials. The data used in this research are qualitative and quantitative data. Qualitative data in this study is data obtained through validation from material experts, media experts, while quantitative data in this study were obtained through assessment questionnaires which were analyzed with descriptive statistics.This research was conducted using "Research and Development" (Research and Development), namely the research method used to produce certain products. The model used as a reference is the Borg & Gall development research model with 10 developments, in this study the researcher adopted the following stages: 1) Preliminary Study (research and data collection). 2) Prepare a plan and analyze the media to be made. 3) Initial product development by producing learning media with validation by media experts and material experts. 4) Conduct small group trials. 5) Product Revisions. 6) Conduct field trials. 7) Revise the final product. For this early stage research, it has only arrived at the fourth stage (4), namely the initial stage validation by media experts and material experts. Research results in the form of learning media products for practical material with a score of 3.67 with good criteria and for media with a score of 3.3 with a fairly good category.


Author(s):  
Michael Kinch

Despite and arguably because of the enormous public health benefits arising from the introduction of new medicines, the industry is in the midst of crisis. We detail in this chapter the decline in research and development efficiency, which has been termed “Eroom's Law,” a playful inversion of the bettern known Moore's Law of Computing. An explanation of declining efficiency follows as is a brief summary of some remedies taken by many biopharmaceutical entities, including the abandonment of therapeutics targeting particularly difficult indications such as Alzheimer's disease and antibiotics. We also convey how the industry has developed into a sort of food chain, with smaller companies and government grants supporting the earliest stages of research, which are then acquired by medium-sized companies, which in turn are consolidated into large companies. This food chain is fundamentally in doubt based on shrinking Federal spending on research combined with a decline in venture capital support for early-stage start-ups.


2019 ◽  
Vol 4 (1) ◽  
pp. 11 ◽  
Author(s):  
Callie J. Weber ◽  
Joseph Hargan-Calvopiña ◽  
Katy M. Graef ◽  
Cathyryne K. Manner ◽  
Jennifer Dent

Schistosomiasis is an acute and chronic disease that affects over 200 million people worldwide, and with over 700 million people estimated to be at risk of contracting this disease, it is a pressing issue in global health. However, research and development (R&D) to develop new approaches to preventing, diagnosing, and treating schistosomiasis has been relatively limited. Praziquantel, a drug developed in the 1970s, is the only agent used in schistosomiasis mass drug administration (MDA) campaigns, indicating a critical need for a diversified therapeutic pipeline. Further, gaps in the vaccine and diagnostic pipelines demonstrate a need for early-stage innovation in all areas of schistosomiasis product R&D. As a platform for public-private partnerships (PPPs), the WIPO Re:Search consortium engages the private sector in early-stage R&D for neglected diseases by forging mutually beneficial collaborations and facilitating the sharing of intellectual property (IP) assets between the for-profit and academic/non-profit sectors. The Consortium connects people, resources, and ideas to fill gaps in neglected disease product development pipelines by leveraging the strengths of these two sectors. Using WIPO Re:Search as an example, this article highlights the opportunities for the PPP model to play a key role in the elimination of schistosomiasis.


2020 ◽  
Vol 10 (7) ◽  
pp. 2574 ◽  
Author(s):  
Donatas Mažeika ◽  
Rimantas Butleris

This paper presents how Model-Based System Engineering (MBSE) could be leveraged in order to mitigate security risks at an early stage of system development. Primarily, MBSE was used to manage complex engineering projects in terms of system requirements, design, analysis, verification, and validation activities, leaving security aspects aside. However, previous research showed that security requirements and risks could be tackled in the MBSE model, and powerful MBSE tools such as simulation, change impact analysis, automated document generation, validation, and verification could be successfully reused in the multidisciplinary field. This article analyzes various security-related techniques and then clarifies how these techniques can be represented in the Systems Modeling Language (SysML) model and then further exploited with MBSE tools. The paper introduces the MBSEsec method, which gives guidelines for the security analysis process, the SysML/UML-based security profile, and recommendations on what security technique is needed at each security process phase. The MBSEsec method was verified by creating an application case study that reflects real-world problems and running an experiment where systems and security engineers evaluated the feasibility of our approach.


2020 ◽  
Vol 25 (4) ◽  
Author(s):  
Richard Murphey

Biopharmaceutical research and development (R&D) productivity has been steadily declining for several decades.  Preliminary evidence suggests that this trend is stabilizing or reversing.  One hypothesis explaining this improvement in R&D productivity is that the industry has shifted early-stage R&D activity from large multinational pharmaceutical companies to more smaller venture-backed startup companies.  We examine recent trends in FDA approvals and biopharmaceutical R&D investment to develop a framework to evaluate whether small companies are more productive at R&D than larger companies.


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