The antiproliferative effects of cold atmospheric plasma-activated media on different cancer cell lines, the implication of ozone as a possible underlying mechanism

<p class="Abstract">The present study investigates the effect of rubriflordilactone A on the viability and its underlying mechanism in gastric cancer cell lines (SNU-1 and SNU-5) and normal gastric epithelial cell line (GES‑1). Incubation of the gastric cancer and non cancer cell lines in acidic media led to reduction in the viability of the non cancer cells without any effect on cancer cells. Apoptosis in SNU-1 and SNU-5 cells was induced on exposure to rubriflordilactone A after 48 hours compared to the control cells (p<0.01). The percentage of apoptosis in SNU-1 and SNU-5 cells on exposure to rubriflordilactone A was 79.3 ± 4.7 and 74.0 ± 5.1, respectively after 48 hours. Exposure of SNU-1 and SNU-5 cancer cell lines to rubriflordilactone A at a concentration of 10 μM in media with acidic pH decreased phosphorylation of ERK ½. The similar reduction was caused by ERK 1/2 phosphorylation inhibition, PD98059. Thus rubriflordilactone A reduces viability of gastric cancer cell lines by inducing apoptosis through the reduction of ERK 1/2 phosphorylation.</p><p> </p>

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288. Synergism between a Conditionally Replicating Adenovirus Expressing p53 and Oxaliplatin in the Antiproliferative Effects on Human Colon Cancer Cell Lines

Molecular Therapy ◽

10.1016/j.ymthe.2004.06.229 ◽

2004 ◽

Vol 9 ◽

pp. S110

Keyword(s):

Colon Cancer ◽

Cell Lines ◽

Cancer Cell ◽

Human Colon ◽

Cancer Cell Lines ◽

Colon Cancer Cell ◽

Human Colon Cancer Cell ◽

Human Colon Cancer ◽

Antiproliferative Effects ◽

Colon Cancer Cell Lines

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Synthesis, Anticancer Activity, and Molecular Modeling of New Halogenated Spiro[pyrrolidine-thiazolo-oxindoles] Derivatives

Applied Sciences ◽

10.3390/app10062170 ◽

2020 ◽

Vol 10 (6) ◽

pp. 2170 ◽

Cited By ~ 3

Author(s):

Mohammad Shahidul Islam ◽

Abdullah Mohammed Al-Majid ◽

Fardous F. El-Senduny ◽

Farid A. Badria ◽

A. F. M. Motiur Rahman ◽

...

Keyword(s):

Cell Lines ◽

Cancer Cell ◽

Cancer Cell Lines ◽

Single Step ◽

One Pot ◽

Antiproliferative Effects ◽

Physiochemical Parameters ◽

Hct 116 ◽

Mcf 7

A one-pot, single-step, and an atom-economical process towards the synthesis of highly functionalized spirooxindoles analogues was efficiently conducted to produce a satisfactory chemical yields (70–93%) with excellent relative diastereo-, and regio-selectivity. An in vitro antiproliferative assay was carried out on different cancer cell lines to evaluate the biological activity of the synthesized tetrahydro-1’H-spiro[indoline-3,5’-pyrrolo[1,2-c]thiazol]-2-one 5a–n. The prepared hybrids were then tested in vitro for their antiproliferative effects against three cancer cell lines, namely, HepG2 (liver cancer), MCF-7 (breast cancer), and HCT-116 (colon cancer). The spirooxindole analogue 5g exhibited a broad activity against HepG2, MCF-7, and HCT-116 cell lines of liver, breast, and colorectal cancers when compared to cisplatin. Modeling studies including shape similarity, lipophilicity scores, and physicochemical parameters were calculated. The results of this study indicated that spirooxindole analogue 5g retained a good physiochemical parameters with acceptable lipophilicity scores.

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A Chromone from Seseli praecox (Apiaceae)

Natural Product Communications ◽

10.1177/1934578x1000500411 ◽

2010 ◽

Vol 5 (4) ◽

pp. 1934578X1000500

Author(s):

Marco Leonti ◽

Laura Casu ◽

Maria Novella Solinas ◽

Filippo Cottiglia ◽

Pierluigi Caboni ◽

...

Keyword(s):

Cell Lines ◽

Cancer Cell ◽

Cancer Cell Lines ◽

Chemical Investigation ◽

Adherent Cells ◽

Biological Characterization ◽

Antiproliferative Effects ◽

Natural Precursor

Chemical investigation of the stems of Seseli praecox (Gamisans) Gamisans, an endemic Apiaceae from Sardinia, afforded an isopropenylated chromone (5-hydroxy-6-(2- Z-butenyl-3-hydroxymethyl)-7-methoxy-2-methylchromone), along with four known linear furocoumarins and their natural precursor. For biological characterization the new compound was screened against four cancer cell lines in vitro and showed differential μM antiproliferative effects between suspension and adherent cells.

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