The mitochondrial‐targeted reactive species scavenger JP4 ‐039 prevents sulfite‐induced alterations in antioxidant defenses, energy transfer, and cell death signaling in striatum of rats

Cell death related (CDR) proteins are a diverse group of proteins whose original function was ascribed to apoptotic cell death signaling. Recently, descriptions of non-apoptotic functions for CDR proteins have increased. In this minireview, we comment on recent studies of CDR proteins outside the field of apoptosis in the CNS, encompassing areas such as the inflammasome and non-apoptotic cell death, cytoskeleton reorganization, synaptic plasticity, mitophagy, neurodegeneration and calcium signaling among others. Furthermore, we discuss the evolution of proteomic techniques used to predict caspase substrates that could potentially explain their non-apoptotic roles. Finally, we address new concepts in the field of non-apoptotic functions of CDR proteins that require further research such the effect of sexual dimorphism on non-apoptotic CDR protein function and the emergence of zymogen-specific caspase functions.

Download Full-text

Differentiating life and death: An inflammatory affair

10.7287/peerj.preprints.27080v1 ◽

2018 ◽

Author(s):

Dustin Lane

Keyword(s):

Cell Cycle ◽

Dna Damage ◽

Cell Death ◽

Cell Differentiation ◽

Programmed Cell Death ◽

Signaling Networks ◽

Inhibitors Of Apoptosis ◽

Life And Death ◽

Cell Death Signaling ◽

Cycle Dependent

Programmed cell death signaling networks are frequently activated to coordinate the process of cell differentiation, and a variety of apoptotic events can mediate the process. This can include the ligation of death receptors, the activation of downstream caspases, and the induction of chromatin fragmentation, and all of these events can occur without downstream induction of death. Importantly, regulators of programmed cell death also have established roles in mediating differentiation. This review will provide an overview of apoptosis and its regulation by Inhibitors of Apoptosis (IAPs) and Bcl-2 family members. It will then outline the cross-talk between NF-ĸB and apoptotic signaling in the regulation of apoptosis before discussing the function of these regulators in the control of cell differentiation. It will end on a discussion of how a DNA damage-directed, cell cycle-dependent differentiation program may be controlled across multiple passages through cell cycle, and will assert that the failure to properly differentiate is the underlying cause of cancer.

Download Full-text

The dependence receptor DCC requires lipid raft localization for cell death signaling

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.0507864103 ◽

2006 ◽

Vol 103 (11) ◽

pp. 4128-4133 ◽

Cited By ~ 35

Author(s):

C. Furne ◽

V. Corset ◽

Z. Herincs ◽

N. Cahuzac ◽

A.-O. Hueber ◽

...

Keyword(s):

Cell Death ◽

Lipid Raft ◽

Cell Death Signaling ◽

Dependence Receptor

Download Full-text

Involvement of Reactive Species of Oxygen and Nitrogen in Triggering Programmed Cell Death in Plants

Biotic and Abiotic Stress Tolerance in Plants ◽

10.1007/978-981-10-9029-5_10 ◽

2018 ◽

pp. 257-278 ◽

Cited By ~ 4

Author(s):

Vineet Kumar Maurya ◽

Dhananjay Kumar ◽

Chandramani Pathak ◽

Budhi Sagar Tiwari

Keyword(s):

Cell Death ◽

Programmed Cell Death ◽

Reactive Species

Download Full-text

Selective cytotoxicity mechanisms and biodistribution of diamond nanoparticles on the skin cancer in C57 mouse

Biomedical Materials ◽

10.1088/1748-605x/ac3d99 ◽

2021 ◽

Author(s):

Elham Moradi ◽

Parvaneh Naserzadeh ◽

Peiman Brouki Millan ◽

Behnaz Ashtari

Keyword(s):

Cell Death ◽

Skin Cancer ◽

Cytochrome C ◽

Biological Activities ◽

Cytochrome C Release ◽

Diamond Nanoparticles ◽

Test Conditions ◽

Mda Content ◽

Cell Death Signaling ◽

High Cytotoxicity

Abstract The cytotoxicity of diamond nanoparticles (DNs) to various cell lines has been on focus by numerous scientists. The cellular toxicity system of DNs has not been fully understood or explained in skin cancer, at this point. This research was carried out to discover and reveal the potential impacts of DNs on the secluded brain, heart, liver, kidney, and skin in addition to evaluation of their cytotoxicity mechanism under test conditions. Their biological activities, for example cell viability, the level of reactive oxygen species (ROS), lipid peroxidation, cytochrome c release and Apoptosis/Necrosis were evaluated. Additionally, the bio-distribution of these nanomaterials in tissues was examined in the C57 mouse. Relying on the findings of the investigation, DNs were found to increase the ROS level, MDA content, release of cytochrome c, and cell death in skin significantly compared to other groups. In the C57 mouse, DNs were observed to have accumulated in skin tissue more intensively than they did in other organs. The present study presents for the the proof that DNs can completely induce cell death signaling in skin cancer without bringing about a high cytotoxicity in other tissues. Results suggest that DNs can be valuable in recognition of skin cancer.

Download Full-text