Association of KLOTHO gene polymorphisms with knee osteoarthritis in Greek population

Background: Molecular biology tools, such as the detection of single nucleotide polymorphisms (SNPs), have been considered to assist to the management of the ovarian stimulation protocols. Purpose: The aim of this study was to evaluate the impact of two polymorphisms, the Asn680Ser polymorphism of the FSHR gene, and the FSH β subunit (FSHβ) gene polymorphism -211 G>T, in a Greek population of women undergoing IVF/ICSI program in our center. In addition, a control group of fertile women was studied, to verify whether there are differences in the genotype distribution between fertile and infertile population for both polymorphisms, as the FSHβ gene polymorphism -211 G>T is studied for the first time in the Greek population. Results : The FSH β-211 G>T polymorphism, studied for the first time in the Greek infertile population, appears to be quite rare. When studying the two polymorphisms separately, statistically significant differences were obtained that concerned the LH levels. Discussion: According to the combination analysis of the two polymorphisms by the number of alleles, women with 2-3 polymorphic alleles needed more days of stimulation, but there were no differences in pregnancy rates. Conclusion: This molecular genetic study helps to elucidate whether the polygenic combination of the Asn680Ser and FSH β subunit -211 G>T gene polymorphisms is of additive value in the prediction of ovarian response to exogenous gonadotropins.

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Investigation of associations of ARMS2, CD14, and TLR4 gene polymorphisms with wet age-related macular degeneration in a Greek population

Clinical Ophthalmology ◽

10.2147/opth.s134538 ◽

2017 ◽

Vol Volume 11 ◽

pp. 1347-1358 ◽

Cited By ~ 5

Author(s):

Antonia Sarli ◽

Iosif Skalidakis ◽

Aliki Velissari ◽

Chryssanthi Koutsandrea ◽

Maria Stefaniotou ◽

...

Keyword(s):

Macular Degeneration ◽

Gene Polymorphisms ◽

Age Related Macular Degeneration ◽

Greek Population ◽

Age Related ◽

Em Gene

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Vitamin D Receptor Gene Polymorphisms and Risk of Knee Osteoarthritis: Possible Correlations with TNF-α, Macrophage Migration Inhibitory Factor, and 25-Hydroxycholecalciferol Status

Biochemical Genetics ◽

10.1007/s10528-021-10116-0 ◽

2021 ◽

Author(s):

Mohammed H. Hassan ◽

Amer Alkot Mostafa Elsadek ◽

Marwa Ahmed Mahmoud ◽

Bakheet E. M. Elsadek

Keyword(s):

Vitamin D ◽

Knee Osteoarthritis ◽

Gene Polymorphisms ◽

Macrophage Migration Inhibitory Factor ◽

Receptor Gene ◽

Vitamin D Receptor Gene ◽

Macrophage Migration ◽

Tnf Α ◽

Receptor Gene Polymorphisms ◽

25 Hydroxycholecalciferol

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Apoptosis-related Fas and FasL gene polymorphisms’ associations with knee osteoarthritis

Rheumatology International ◽

10.1007/s00296-013-2688-1 ◽

2013 ◽

Vol 33 (8) ◽

pp. 2039-2043 ◽

Cited By ~ 8

Author(s):

Melek Sezgin ◽

İbrahim Ömer Barlas ◽

Seyfi Yıldır ◽

Gözde Türköz ◽

Handan Çamdeviren Ankaralı ◽

...

Keyword(s):

Knee Osteoarthritis ◽

Gene Polymorphisms ◽

Fasl Gene

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Role of CYP4F2, CYP2C19, and CYP1A2 polymorphisms on acenocoumarol pharmacogenomic algorithm accuracy improvement in the Greek population: need for sub-phenotype analysis

Drug Metabolism and Personalized Therapy ◽

10.1515/dmpt-2017-0034 ◽

2017 ◽

Vol 32 (4) ◽

Author(s):

Georgia Ragia ◽

Ioanna-Maria Karantza ◽

Eleni Kelli-Kota ◽

Vana Kolovou ◽

Genovefa Kolovou ◽

...

Keyword(s):

Gene Polymorphisms ◽

Greek Population ◽

Accuracy Improvement ◽

Additional Gene ◽

Stable Dose ◽

Dose Prediction ◽

Weak Association ◽

Phenotype Analysis ◽

Pooled Sample

AbstractBackground:We have earlier developed a pharmacogenomic algorithm for acenocoumarol dose prediction in Greek patients that includedMethods:A total of 205 Greek patients taking acenocoumarol (140 who reached and 65 who did not reach stable dose), participants of acenocoumarol EU-PACT trial, were included in the study.Results:In the pooled sample,Conclusions:gene shows a prominent weak association with acenocoumarol dose requirements. Sub-phenotype analysis is potentially important in determining additional gene polymorphisms that are associated with acenocoumarol dose requirements.

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Complement factor H and LOC387715 gene polymorphisms in a Greek population with age-related macular degeneration

Graefe s Archive for Clinical and Experimental Ophthalmology ◽

10.1007/s00417-009-1129-z ◽

2009 ◽

Vol 247 (11) ◽

pp. 1547-1553 ◽

Cited By ~ 7

Author(s):

Dimitra I. Marioli ◽

Nikolaos Pharmakakis ◽

Angeliki Deli ◽

Ioannis Havvas ◽

Ioannis K. Zarkadis

Keyword(s):

Macular Degeneration ◽

Gene Polymorphisms ◽

Factor H ◽

Age Related Macular Degeneration ◽

Greek Population ◽

Complement Factor H ◽

Complement Factor ◽

Age Related

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Klotho gene polymorphisms and their association with sickle cell disease phenotypes

Revista Brasileira de Hematologia e Hemoterapia ◽

10.1016/j.bjhh.2015.02.009 ◽

2015 ◽

Vol 37 (4) ◽

pp. 275-276 ◽

Cited By ~ 1

Author(s):

Claudia R. Lustosa Souza ◽

Marily M. Azevedo Shimmoto ◽

Perla Vicari ◽

Grazielle Mecabo ◽

Martha Mariana Arruda ◽

...

Keyword(s):

Sickle Cell Disease ◽

Sickle Cell ◽

Gene Polymorphisms ◽

Cell Disease ◽

Disease Phenotypes ◽

Klotho Gene

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Association between the polymorphism of IL-17A and IL-17F gene with knee osteoarthritis risk: a meta-analysis based on case-control studies

Journal of Orthopaedic Surgery and Research ◽

10.1186/s13018-019-1495-0 ◽

2019 ◽

Vol 14 (1) ◽

Cited By ~ 1

Author(s):

Feifan Lu ◽

Pei Liu ◽

Qidong Zhang ◽

Weiguo Wang ◽

Wanshou Guo

Keyword(s):

Knee Osteoarthritis ◽

Gene Polymorphisms ◽

Meta Analysis ◽

Case Control ◽

Joint Disease ◽

Cochrane Library ◽

Case Control Studies ◽

Knee Oa ◽

Statistical Heterogeneity ◽

Bone Changes

Abstract Background Knee osteoarthritis is a joint disease which is characterized by degeneration of articular cartilage and subsequent subchondral bone changes. Polymorphisms of IL-17A/F gene were the recognized candidate genes associated with knee osteoarthritis risk although the results were conflicting. The aim of this study was to determine whether IL-17A(rs2275913) and IL-17F(rs763780) polymorphisms confer susceptibility to knee osteoarthritis. Method Literature search was performed in PubMed, Medline, Cochrane Library, Web of science, Embase, and Google Scholar (last search was updated on June 20, 2019), and assessing this association was performed by calculating odds ratios with 95% confidence intervals. Statistical heterogeneity was quantitatively evaluated by using the Q statistic with its p value and I2 statistic. Result Six case-control based studies were included involving IL-17A(rs2275913) (2134 cases and 2306 controls) and IL-17F(rs763780) (2134 cases and 2426 controls). The overall analysis suggested that the A allele of the rs2275913 polymorphism, and the C allele of the rs763780 polymorphism in the IL-17 gene may increase the risk of OA. However, subgroup analysis revealed that no association between IL-17A(rs2275913) gene and knee OA risk was found in Caucasian population. Conclusions This meta-analysis revealed that the IL-17A(rs2275913) gene polymorphisms may increase the risk of knee OA in Asians, and the IL-17F(rs763780) gene polymorphisms may increase the risk of knee OA both in Asians and Caucasians. However, because of the limitations of the present study, additional larger studies are needed to confirm our findings in the future.

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