Integrated Design of a Mussel‐Inspired Hydrogel Biofilm Composite Structure to Guide Bone Regeneration

Aims The use of 3D-printed titanium implant (DT) can effectively guide bone regeneration. DT triggers a continuous host immune reaction, including macrophage type 1 polarization, that resists osseointegration. Interleukin 4 (IL4) is a specific cytokine modulating osteogenic capability that switches macrophage polarization type 1 to type 2, and this switch favours bone regeneration. Methods IL4 at concentrations of 0, 30, and 100 ng/ml was used at day 3 to create a biomimetic environment for bone marrow mesenchymal stromal cell (BMMSC) osteogenesis and macrophage polarization on the DT. The osteogenic and immune responses of BMMSCs and macrophages were evaluated respectively. Results DT plus 30 ng/ml of IL4 (DT + 30 IL4) from day 3 to day 7 significantly (p < 0.01) enhanced macrophage type 2 polarization and BMMSC osteogenesis compared with the other groups. Local injection of IL4 enhanced new bone formation surrounding the DT. Conclusion DT + 30 IL4 may switch macrophage polarization at the appropriate timepoints to promote bone regeneration. Cite this article: Bone Joint Res 2021;10(7):411–424.

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Guide bone regeneration using autogenous teeth: case reports

Journal of the Korean Association of Oral and Maxillofacial Surgeons ◽

10.5125/jkaoms.2011.37.2.142 ◽

2011 ◽

Vol 37 (2) ◽

pp. 142 ◽

Cited By ~ 18

Author(s):

Young-Kyun Kim ◽

Hyo-Jung Lee ◽

Kyung-Wook Kim ◽

Su-Gwan Kim ◽

In-Woong Um

Keyword(s):

Bone Regeneration ◽

Case Reports ◽

Guide Bone Regeneration

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Data Mining-Based Clinical Study on the Effect of Oral Restoration Film in Guiding Oral Bone Regeneration and Dental Implantation

Journal of Healthcare Engineering ◽

10.1155/2021/3804271 ◽

2021 ◽

Vol 2021 ◽

pp. 1-8

Author(s):

Qingjie Lin ◽

Yong Zhang ◽

Yanguo Liu

Keyword(s):

Data Mining ◽

Bone Regeneration ◽

Bone Tissue ◽

Vital Signs ◽

Control Group ◽

Clinical Effects ◽

Guide Bone Regeneration ◽

Barrier Membrane ◽

Dental Implantation ◽

Significant Difference

Oral repair membrane guided oral bone regeneration, particularly in dental implants, is a guided regeneration technology for bone tissue. The principle is based on the characteristics of rapid migration of epithelial cells and fibroblasts and slower migration of osteoblasts. Materials are placed in the bone defect, creating a relatively closed environment which is conducive to the growth of bone tissue. In this paper, we have evaluated clinical effects of Hai’ao oral repair membrane as a barrier membrane to guide bone regeneration in implants. For this purpose, certain treatment data are collected through data mining and patient’s names with bone defects in the implantation area are selected. According to the randomness principles, these patients are divided into experimental and control groups and preoperative examinations along with basic periodontal treatments are performed on the selected cases. Furthermore, we have analyzed different effects by comparing treatment conditions. Experimental results, as a technical shielding film, verify that Hai’ao oral repair membrane meets requirements of safety and no immune rejection. It plays a role in promoting bone formation around the implant. Mid-to-long-term follow-up is satisfactory with no related complications. At the same time, it has the advantages of simple operation, reduced patient suffering, convenient transportation and storage, and longer validity period. Compared with the control group in terms of safety evaluation of postoperative vital signs, laboratory examinations, and incision healing, Hai’ao oral repair membrane has no significant difference. Postoperative osteogenesis effect is equivalent to that of the control group and meets requirements of superiority. Hai’ao oral repair membrane is used as a shielding membrane material in implant surgery technology to guide bone regeneration.

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Decellularized bone extracellular matrix in skeletal tissue engineering

Biochemical Society Transactions ◽

10.1042/bst20190079 ◽

2020 ◽

Vol 48 (3) ◽

pp. 755-764

Author(s):

Benjamin B. Rothrauff ◽

Rocky S. Tuan

Keyword(s):

Tissue Engineering ◽

Bone Regeneration ◽

Tissue Regeneration ◽

Animal Studies ◽

Tumor Resection ◽

Regenerative Capacity ◽

Skeletal Tissue ◽

Large Bone

Bone possesses an intrinsic regenerative capacity, which can be compromised by aging, disease, trauma, and iatrogenesis (e.g. tumor resection, pharmacological). At present, autografts and allografts are the principal biological treatments available to replace large bone segments, but both entail several limitations that reduce wider use and consistent success. The use of decellularized extracellular matrices (ECM), often derived from xenogeneic sources, has been shown to favorably influence the immune response to injury and promote site-appropriate tissue regeneration. Decellularized bone ECM (dbECM), utilized in several forms — whole organ, particles, hydrogels — has shown promise in both in vitro and in vivo animal studies to promote osteogenic differentiation of stem/progenitor cells and enhance bone regeneration. However, dbECM has yet to be investigated in clinical studies, which are needed to determine the relative efficacy of this emerging biomaterial as compared with established treatments. This mini-review highlights the recent exploration of dbECM as a biomaterial for skeletal tissue engineering and considers modifications on its future use to more consistently promote bone regeneration.

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Integrating Safety and Crew Resource Management (CRM) Aspects in the Recurrent Training of Cabin Crew Members

Aviation Psychology and Applied Human Factors ◽

10.1027/2192-0923/a00007 ◽

2011 ◽

Vol 1 (1) ◽

pp. 45-51 ◽

Cited By ~ 5

Author(s):

Sandrina Ritzmann ◽

Annette Kluge ◽

Vera Hagemann ◽

Margot Tanner

Keyword(s):

Resource Management ◽

Integrated Design ◽

Crew Resource Management ◽

Training Module ◽

Cabin Crew ◽

Training Cycle ◽

Aviation Training ◽

Training Format ◽

Instructional Design Principles ◽

Practical Instruction

Recurrent training of cabin crew should include theoretical and practical instruction on safety as well as crew resource management (CRM) issues. The endeavors of Swiss International Air Lines Ltd. and Swiss Aviation Training Ltd. to integrate CRM and safety aspects into a single training module were evaluated. The objective of the integration was to make CRM more tangible and ease acquisition of competencies and transfer of CRM training content to practice by showing its relevance in relation to safety tasks. It was of interest whether the integrated design would be mirrored in a more favorable perception by the trainees as measured with a questionnaire. Participants reacted more positively to the integrated training than to stand-alone CRM training, although the integrated training was judged as being slightly more difficult and less oriented toward instructional design principles. In a range of forced-choice questions, the majority of participants opted for an integrated training format because it was seen as livelier and more interesting and also more practically relevant. For the forthcoming training cycle, a better alignment of training with instructional principles and an even higher degree of training integration by using simulator scenarios are striven for.

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