Vitamin D concentration and lateral cerebral ventricle volume in older adults

Background: Vitamin D insufficiency is associated with brain changes, and cognitive and mobility declines in older adults. Method: Two hundred and fifteen Caucasian older community-dwellers (mean±SD, 72.1±5.5years; 40% female) received a blood test and brain MRI. The thickness of perigenual anterior cingulate cortex, midcingulate cortex and posterior cingulate cortex was measured using FreeSurfer from T1-weighted MR images. Age, gender, education, BMI, mean arterial pressure, comorbidities, use of vitamin D supplements or anti-vascular drugs, MMSE, GDS, IADL, serum calcium and vitamin B9 concentrations, creatinine clearance were used as covariables. Results: Participants with vitamin D insufficiency (n=80) had thinner total cingulate thickness than the others (24.6±1.9mm versus 25.3±1.4mm, P=0.001); a significant difference found for all 3 regions. Vitamin D insufficiency was cross-sectionally associated with a decreased total cingulate thickness (β=- 0.49, P=0.028). Serum 25OHD concentration correlated positively with the thickness of perigenual anterior (P=0.011), midcingulate (P=0.013) and posterior cingulate cortex (P=0.021). Conclusion: Vitamin D insufficiency was associated with thinner cingulate cortex in the studied sample of older adults. These findings provide insight into the pathophysiology of cognitive and mobility declines in older adults with vitamin D insufficiency.

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Vitamin D and Hospital Admission in Older Adults: A Prospective Association

Nutrients ◽

10.3390/nu13020616 ◽

2021 ◽

Vol 13 (2) ◽

pp. 616

Author(s):

Avril Beirne ◽

Kevin McCarroll ◽

James Bernard Walsh ◽

Miriam Casey ◽

Eamon Laird ◽

...

Keyword(s):

Older Adults ◽

Vitamin D ◽

Hospital Admission ◽

Cross Sectional Study ◽

Vitamin D Supplementation ◽

Inverse Association ◽

Cross Sectional ◽

Prospective Association ◽

Randomised Controlled

The health effects of vitamin D are well documented, with increasing evidence of its roles beyond bone. There is, however, little evidence of the effects of vitamin D on hospitalisation among older adults. This study aimed to prospectively determine the relationship of vitamin D status in older adults with hospital admission and emergency department (ED) attendance. Trinity University of Ulster Department of Agriculture (TUDA) is a large cross-sectional study of older adults with a community population from three disease-defined cohorts (cognitive dysfunction, hypertension, and osteoporosis). Participants included in this analysis were recruited between 2008 and 2012. ED and hospital admission data were gathered from the date of TUDA participation until June 2013, with a mean follow up of 3.6 years. Of the 3093 participants, 1577 (50.9%) attended the ED during the period of follow-up. Attendees had lower mean serum 25(OH)D concentrations than non-attendees (59.1 vs. 70.6 nmol/L). Fully adjusted models showed an inverse association between vitamin D and ED attendance (Hazard Ratio (HR) 0.996; 95% Confidence Interval (CI) 0.995–0.998; p < 0.001). A total of 1269 participants (41%) were admitted to hospital during the follow-up. Those admitted had lower mean vitamin D concentrations (58.4 vs. 69.3 nmol/L, p < 0.001). In fully adjusted models, higher vitamin D was inversely associated with hospital admission (HR 0.996; 95% CI 0.994–0.998; p < 0.001) and length of stay (LOS) (β = −0.95, p = 0.006). This study showed independent prospective associations between vitamin D deficiency and increased hospitalisation by older adults. The need for further evaluation of current recommendations in relation to vitamin D supplementation, with consideration beyond bone health, is warranted and should focus on randomised controlled trials.

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Risk of Osteoarthritis is Positively Associated with Vitamin D Status, but Not Bone Mineral Density, in Older Adults in the United States

Journal of the American College of Nutrition ◽

10.1080/07315724.2020.1787907 ◽

2021 ◽

pp. 1-9

Author(s):

Hansaem Park ◽

Clara Yongjoo Park

Keyword(s):

United States ◽

Bone Mineral Density ◽

Older Adults ◽

Vitamin D ◽

Bone Mineral ◽

The United States ◽

Vitamin D Status ◽

Mineral Density

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Vitamin D Assessment in Older Adults

Handbook of Famine, Starvation, and Nutrient Deprivation ◽

10.1007/978-3-319-40007-5_59-1 ◽

2017 ◽

pp. 1-15

Author(s):

Christopher Nnaemeka Osuafor ◽

Marguerite MacMahon ◽

Cora McGreevy ◽

Chie Wei Fan

Keyword(s):

Older Adults ◽

Vitamin D

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Vitamin D in Household Food Supplies of Homebound Older Adults Receiving Home-Delivered Meals

Topics in Clinical Nutrition ◽

10.1097/tin.0000000000000121 ◽

2017 ◽

Vol 32 (4) ◽

pp. 282-291

Author(s):

Nancy F. Lashway ◽

William K. Hallman ◽

Carol Byrd-Bredbenner ◽

Cara L. Cuite ◽

Rita M. McWilliams ◽

...

Keyword(s):

Older Adults ◽

Vitamin D ◽

Household Food ◽

Homebound Older Adults

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Environmental and genetic determinants of vitamin D status among older adults in London, UK

The Journal of Steroid Biochemistry and Molecular Biology ◽

10.1016/j.jsbmb.2016.01.005 ◽

2016 ◽

Vol 164 ◽

pp. 30-35 ◽

Cited By ~ 19

Author(s):

David A. Jolliffe ◽

Yasmeen Hanifa ◽

Karolina D. Witt ◽

Timothy R. Venton ◽

Marion Rowe ◽

...

Keyword(s):

Older Adults ◽

Vitamin D ◽

Vitamin D Status ◽

Genetic Determinants

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Whey protein and vitamin D supplementation in institutionalized older adults: A randomized trial

Nutrition and Health ◽

10.1177/02601060211060665 ◽

2021 ◽

pp. 026010602110606

Author(s):

Tamy Colonetti ◽

Antônio Jose Grande ◽

Franciani Rodrigues da Rocha ◽

Eduardo Ronconi Dondossola ◽

Lisiane Tuon ◽

...

Keyword(s):

Older Adults ◽

Vitamin D ◽

Body Composition ◽

Resistance Training ◽

Whey Protein ◽

Muscle Mass ◽

Lean Mass ◽

Vitamin D Supplementation ◽

Relative Index ◽

And Control

Background: The increase in life expectancy and in the number of individuals over 60 years old brings new demands to health professionals and services based on the physiological changes that occur in this population. The aging process results in changes in body composition, increasing body fat and reducing muscle mass, in addition to a reduction in bone mass. Aim: The aim of this study was to examine the effect of whey protein and vitamin D supplementation on body composition and skeletal muscle in older adults living in long-term care facilities. Methods: This study is a double-blind randomized controlled trial. Thirty older adults (>60 years old) were randomized and allocated in three groups: group receiving resistance training and supplementation receiving resistance training, whey protein and vitamin D; group received resistance and placebo training receiving resistance training and placebo, and control group without any intervention. Body composition was measured by dual-energy X-ray absorptiometry at baseline, 12 weeks, and 24 weeks. Results: The mean age was 74.87 (± 8.14) years. A significant difference ( p = 0.042) was observed between the group receiving resistance training and supplementation and control groups in relation to lean mass increase (kg) at 24 weeks. After 24 weeks of intervention, there was a significant increase in Relative index of muscle mass for the two groups that underwent resistance training, group received resistance and placebo training ( p = 0.042) and group receiving resistance training and supplementation ( p = 0.045), in relation to the control. Conclusion: Combined supplementation of whey protein and vitamin D with resistance training can significantly improve lean mass, total mass, and relative index of muscle mass in institutionalized older adults.

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ROLE OF VITAMIN D IN COVID VACCINE EFFICACY IN ELDERLY IN INDIAN POPULATION

10.36106/ijar/9004485 ◽

2021 ◽

pp. 55-56

Author(s):

Gujjarlapudi Deepika ◽

Duvuru Nageshwar Reddy

Keyword(s):

Older Adults ◽

Vitamin D ◽

Immune Response ◽

Indian Population ◽

Integrated Approach ◽

Inclusion Criteria ◽

Vitamin D Levels ◽

History Of ◽

Study Inclusion

Background: Aim of this study is to summarise the role of Vitamin D in supporting the immune system,in covid vaccinated recipients. This is a observational study done between April 2021 t Methods: o June 2021 in Indian population. We compared anti-SARS-CoV-2 spike RBDIgG antibody & antispike antibodies following vaccination of non-hospitalized participants along with vitamin D levels in recipients above 60 years. They were tested after vaccination after two doses between 15-45 days. Before study inclusion criteria is, we have checked whether they were as seropositive or seronegative based on nucleocapsid total antibody results. of 310 Results vaccine recipients, 46 reported a prior COVID-19 diagnosis and we have excluded them from the study of the 264 with no history of Covid-19, 70 were vitamin d decient (50M;20 F) & 194 (130 M:64 F) were vitamin d Sufcient. Responses were evaluated after two doses on an average post-vaccine RBD IgG concentration and Spike antibodies were each signicantly higher among the Vit d sufcient recipients compared to the vitamin D Decient recipients. An integrated approach is required to bett Conclusions: er understand aging and how vaccines work in elderly which will help in improving the immune response in older adults after vaccination.

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