Estimations of relative biological effectiveness of secondary fragments in carbon ion irradiation of water using CR‐39 plastic detector and microdosimetric kinetic model

2019 ◽  
Vol 47 (2) ◽  
pp. 781-789 ◽  
Author(s):  
Yoshiyuki Hirano ◽  
Satoshi Kodaira ◽  
Hikaru Souda ◽  
Kohei Osaki ◽  
Masami Torikoshi
Keyword(s):  
Kinetic Model ◽  
Relative Biological Effectiveness ◽  
Ion Irradiation ◽  
Carbon Ion ◽  
Plastic Detector ◽  
Biological Effectiveness

scholarly journals An empirical model to predict survival curve and relative biological effectiveness after helium and carbon ion irradiation based solely on the cell survival after photon irradiation

2020 ◽  
Author(s):  
David B. Flint ◽  
Scott J. Bright ◽  
Conor H. McFadden ◽  
Teruaki Konishi ◽  
Daisuke Ohsawa ◽  
...  
Keyword(s):  
Cell Survival ◽  
Cell Lines ◽  
Empirical Model ◽  
Linear Correlation ◽  
Relative Biological Effectiveness ◽  
Ion Irradiation ◽  
Survival Curve ◽  
Carbon Ion ◽  
Wide Range ◽  
Biological Effectiveness

ABSTRACTPurposeTo develop an empirical model to predict radiosensitivity and relative biological effectiveness (RBE) after helium (He) and carbon (C) ion irradiation with or without DNA repair inhibitors.MethodsWe characterized survival in eight human cancer cell lines exposed to 6 MV photons and to He- and C-ions with linear energy transfer (LET) values of 2.2-60.5 keV/μm to verify that the radiosensitivity parameters (D5%, D10%, D20%, D37%, D50% and SF2Gy) correlate linearly between photon and ion radiation with or without DNA-PKcs or ATR inhibitors. Then, we parameterized the LET response of the parameters governing these linear correlations up to LET values of 225 keV/μm using the data in the Particle Irradiation Data Ensemble (PIDE) v3.2 database, creating a model that predicts a cell’s ion radiosensitivity, RBE and ion survival curve for a given LET on the basis of the cell’s photon radiosensitivity. We then trained this model using the PIDE database as a training dataset, and validated it by predicting the radiosensitivity of the cell lines we exposed to He- and C- ions with LET ranging from 2.2-60.5 keV/μm.ResultsRadiosensitivity to ions depended linearly with radiosensitivity of photons in the range of investigated LET values and the slopes and intercepts of these linear relationships within the PIDE database vary exponentially and linearly, respectively. Our model predicted ion radiosensitivity (e.g., D10%) within 5.1–21.3%, RBED10% within 5.0-17.1%, and ion mean inactivation dose within 6.7-25.1% for He- and C-ion LET ranging from 2.2-60.5 keV/μm.ConclusionsRadiosensitivity to He- and C-ions depend linearly with radiosensitivity to photons and can be used to predict ion radiosensitivity, RBE and cell survival curves for clinically relevant LET values from 2.2–60.5 keV/μm, with or without drug treatment.SUMMARYWe present a new empirical model capable of predicting clonogenic cell survival of cell lines exposed to helium and carbon ion beams. Our model is based on an observed linear correlation between radiosensitivity to ions and photons across a wide range of LET values. This linear correlation can be used to predict ion RBE, radiosensitivity, and the cell survival curve for a given LET all based on a cell’s photon survival curve.

Split dose carbon ion irradiation of the rat spinal cord: Dependence of the relative biological effectiveness on dose and linear energy transfer

2015 ◽  
Vol 117 (2) ◽  
pp. 358-363 ◽  
Author(s):  
Maria Saager ◽  
Christin Glowa ◽  
Peter Peschke ◽  
Stephan Brons ◽  
Rebecca Grün ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Energy Transfer ◽  
Linear Energy Transfer ◽  
Relative Biological Effectiveness ◽  
Ion Irradiation ◽  
Rat Spinal Cord ◽  
Carbon Ion ◽  
Split Dose ◽  
Biological Effectiveness

Carbon Ion Irradiation of the Rat Spinal Cord: Dependence of the Relative Biological Effectiveness on Linear Energy Transfer

2014 ◽  
Vol 90 (1) ◽  
pp. 63-70 ◽  
Author(s):  
Maria Saager ◽  
Christin Glowa ◽  
Peter Peschke ◽  
Stephan Brons ◽  
Michael Scholz ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Energy Transfer ◽  
Linear Energy Transfer ◽  
Relative Biological Effectiveness ◽  
Ion Irradiation ◽  
Rat Spinal Cord ◽  
Carbon Ion ◽  
Biological Effectiveness

WE-H-BRA-01: BEST IN PHYSICS (THERAPY): Nano-Dosimetric Kinetic Model for Variable Relative Biological Effectiveness of Proton and Ion Beams

2016 ◽  
Vol 43 (6Part42) ◽  
pp. 3842-3842 ◽  
Author(s):  
R Abolfath ◽  
L Bronk ◽  
Y Helo ◽  
J Schuemann ◽  
U. Titt ◽  
...  
Keyword(s):  
Kinetic Model ◽  
Relative Biological Effectiveness ◽  
Ion Beams ◽  
Biological Effectiveness

scholarly journals Relative Biological Effectiveness (RBE) for Development of Lung Fibrosis After Single Dose Carbon Ion Radiotherapy (CIRT)

2019 ◽  
Vol 105 (1) ◽  
pp. E644-E645
Author(s):  
C. Zhou ◽  
M. Moustafa ◽  
Z. Zhou ◽  
B. Jones ◽  
S. Brons ◽  
...  
Keyword(s):  
Single Dose ◽  
Lung Fibrosis ◽  
Relative Biological Effectiveness ◽  
Carbon Ion Radiotherapy ◽  
Carbon Ion ◽  
Biological Effectiveness

scholarly journals Proton RBE dependence on dose in the setting of hypofractionation

2020 ◽  
Vol 93 (1107) ◽  
pp. 20190291 ◽  
Author(s):  
Thomas Friedrich
Keyword(s):  
Relative Biological Effectiveness ◽  
Review Article ◽  
Carbon Ion Therapy ◽  
Carbon Ion ◽  
Ion Therapy ◽  
Therapy Costs ◽  
Biological Effectiveness ◽  
Dose Dependent ◽  
Higher Doses ◽  
Patient Burden

Hypofractionated radiotherapy is attractive concerning patient burden and therapy costs, but many aspects play a role when it comes to assess its safety. While exploited for conventional photon therapy and carbon ion therapy, hypofractionation with protons is only rarely applied. One reason for this is uncertainty in the described dose, mainly due to the relative biological effectiveness (RBE), which is small for protons, but not negligible. RBE is generally dose-dependent, and for higher doses as used in hypofractionation, a thorough RBE evaluation is needed. This review article focuses on the RBE variability in protons and associated issues or implications for hypofractionation.

scholarly journals Relation between Lineal Energy Distribution and Relative Biological Effectiveness for Photon Beams according to the Microdosimetric Kinetic Model

2011 ◽  
Vol 52 (1) ◽  
pp. 75-81 ◽  
Author(s):  
Hiroyuki OKAMOTO ◽  
Tatsuaki KANAI ◽  
Yuki KASE ◽  
Yoshitaka MATSUMOTO ◽  
Yoshiya FURUSAWA ◽  
...  
Keyword(s):  
Kinetic Model ◽  
Energy Distribution ◽  
Relative Biological Effectiveness ◽  
Photon Beams ◽  
Lineal Energy ◽  
Biological Effectiveness

scholarly journals The relative biological effectiveness of carbon ion radiation therapy for early stage lung cancer

2020 ◽  
Vol 153 ◽  
pp. 265-271 ◽  
Author(s):  
Jeho Jeong ◽  
Vicki T. Taasti ◽  
Andrew Jackson ◽  
Joseph O. Deasy
Keyword(s):  
Lung Cancer ◽  
Radiation Therapy ◽  
Relative Biological Effectiveness ◽  
Early Stage ◽  
Early Stage Lung Cancer ◽  
Carbon Ion ◽  
Biological Effectiveness ◽  
Stage Lung Cancer
Sign in / Sign up

Export Citation Format

Share Document