scholarly journals Relative Biological Effectiveness (RBE) for Development of Lung Fibrosis After Single Dose Carbon Ion Radiotherapy (CIRT)

2019 ◽  
Vol 105 (1) ◽  
pp. E644-E645
Author(s):  
C. Zhou ◽  
M. Moustafa ◽  
Z. Zhou ◽  
B. Jones ◽  
S. Brons ◽  
...  
Keyword(s):  
Single Dose ◽  
Lung Fibrosis ◽  
Relative Biological Effectiveness ◽  
Carbon Ion Radiotherapy ◽  
Carbon Ion ◽  
Biological Effectiveness

scholarly journals Multi-institutional Retrospective Analysis of Carbon-ion Radiotherapy for Patients with Locally Advanced Adenocarcinoma of the Uterine Cervix

2021 ◽  
Author(s):  
Noriyuki Okonogi ◽  
Ken Ando ◽  
Kazutoshi Murata ◽  
Masaru Wakatsuki ◽  
Shin-ei Noda ◽  
...  
Keyword(s):  
Uterine Cervix ◽  
Tumor Response ◽  
Relative Biological Effectiveness ◽  
Locally Advanced ◽  
Carbon Ion Radiotherapy ◽  
Organ Function ◽  
Carbon Ion ◽  
Biological Effectiveness ◽  
Rapid Regression

The clinical significance of carbon-ion radiotherapy (CIRT) for adenocarcinoma (AC) of the uterine cervix has been assessed in several single-institutional studies. To validate the significance, we conducted a multi-institutional survey of CIRT for locally advanced AC (LAAC) of the uterine cervix. We retrospectively analyzed the clinical outcomes of patients with stage IIB–IVA LAAC of the uterine cervix who underwent chemo-CIRT or CIRT alone between April 2010 and April 2016. Patients received 74.4 Gy (relative biological effectiveness [RBE]) in 20 fractions of CIRT or 55.2 Gy (RBE) in 16 fractions of CIRT plus 3 sessions of brachytherapy. Patients aged ≤70 years with adequate bone marrow and organ function were administered cisplatin weekly (40 mg/m2 per week for up to 5 weeks). Fifty-five patients were enrolled in this study. The median follow-up period was 67.5 months. The 5-year overall survival (OS) and local control (LC) rates were 68.6% and 65.2%, respectively. Multivariate analysis showed that the initial tumor response within 6 months was significantly associated with LC and OS. The present study represents promising outcomes of CIRT or chemo-CIRT for LAAC of the uterine cervix, especially in the cases showing initial rapid regression of the tumor.

scholarly journals Multi-Institutional Retrospective Analysis of Carbon-Ion Radiotherapy for Patients with Locally Advanced Adenocarcinoma of the Uterine Cervix

Cancers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2713
Author(s):  
Noriyuki Okonogi ◽  
Ken Ando ◽  
Kazutoshi Murata ◽  
Masaru Wakatsuki ◽  
Shin-ei Noda ◽  
...  
Keyword(s):  
Uterine Cervix ◽  
Tumor Response ◽  
Relative Biological Effectiveness ◽  
Locally Advanced ◽  
Carbon Ion Radiotherapy ◽  
Organ Function ◽  
Carbon Ion ◽  
Biological Effectiveness ◽  
Rapid Regression

The clinical significance of carbon-ion radiotherapy (CIRT) for adenocarcinoma (AC) of the uterine cervix has been assessed in several single-institutional studies. To validate the significance, we conducted a multi-institutional survey of CIRT for locally advanced AC (LAAC) of the uterine cervix. We retrospectively analyzed the clinical outcomes of patients with stage IIB–IVA LAAC of the uterine cervix who underwent chemo-CIRT or CIRT alone between April 2010 and April 2016. Patients received 74.4 Gy (relative biological effectiveness [RBE]) in 20 fractions of CIRT or 55.2 Gy (RBE) in 16 fractions of CIRT plus three sessions of brachytherapy. Patients aged ≤ 70 years with adequate bone marrow and organ function were administered cisplatin weekly (40 mg/m2 per week for up to 5 weeks). Fifty-five patients were enrolled in this study. The median follow-up period was 67.5 months. The 5-year overall survival (OS) and local control (LC) rates were 68.6% and 65.2%, respectively. Multivariate analysis showed that the initial tumor response within 6 months was significantly associated with LC and OS. The present study represents promising outcomes of CIRT or chemo-CIRT for LAAC of the uterine cervix, especially in the cases showing initial rapid regression of the tumor.

Single-dose relative biological effectiveness and toxicity studies under conditions of hypothermia and hyperbaric oxygen

1986 ◽  
Vol 59 (707) ◽  
pp. 1099-1103 ◽  
Author(s):  
E. R. Hering ◽  
G. Blekkenhorst ◽  
G. G. Harrison ◽  
D. Morrell ◽  
J. Korrubel ◽  
...  
Keyword(s):  
Single Dose ◽  
Hyperbaric Oxygen ◽  
Relative Biological Effectiveness ◽  
Toxicity Studies ◽  
Biological Effectiveness

scholarly journals An empirical model to predict survival curve and relative biological effectiveness after helium and carbon ion irradiation based solely on the cell survival after photon irradiation

2020 ◽  
Author(s):  
David B. Flint ◽  
Scott J. Bright ◽  
Conor H. McFadden ◽  
Teruaki Konishi ◽  
Daisuke Ohsawa ◽  
...  
Keyword(s):  
Cell Survival ◽  
Cell Lines ◽  
Empirical Model ◽  
Linear Correlation ◽  
Relative Biological Effectiveness ◽  
Ion Irradiation ◽  
Survival Curve ◽  
Carbon Ion ◽  
Wide Range ◽  
Biological Effectiveness

ABSTRACTPurposeTo develop an empirical model to predict radiosensitivity and relative biological effectiveness (RBE) after helium (He) and carbon (C) ion irradiation with or without DNA repair inhibitors.MethodsWe characterized survival in eight human cancer cell lines exposed to 6 MV photons and to He- and C-ions with linear energy transfer (LET) values of 2.2-60.5 keV/μm to verify that the radiosensitivity parameters (D5%, D10%, D20%, D37%, D50% and SF2Gy) correlate linearly between photon and ion radiation with or without DNA-PKcs or ATR inhibitors. Then, we parameterized the LET response of the parameters governing these linear correlations up to LET values of 225 keV/μm using the data in the Particle Irradiation Data Ensemble (PIDE) v3.2 database, creating a model that predicts a cell’s ion radiosensitivity, RBE and ion survival curve for a given LET on the basis of the cell’s photon radiosensitivity. We then trained this model using the PIDE database as a training dataset, and validated it by predicting the radiosensitivity of the cell lines we exposed to He- and C- ions with LET ranging from 2.2-60.5 keV/μm.ResultsRadiosensitivity to ions depended linearly with radiosensitivity of photons in the range of investigated LET values and the slopes and intercepts of these linear relationships within the PIDE database vary exponentially and linearly, respectively. Our model predicted ion radiosensitivity (e.g., D10%) within 5.1–21.3%, RBED10% within 5.0-17.1%, and ion mean inactivation dose within 6.7-25.1% for He- and C-ion LET ranging from 2.2-60.5 keV/μm.ConclusionsRadiosensitivity to He- and C-ions depend linearly with radiosensitivity to photons and can be used to predict ion radiosensitivity, RBE and cell survival curves for clinically relevant LET values from 2.2–60.5 keV/μm, with or without drug treatment.SUMMARYWe present a new empirical model capable of predicting clonogenic cell survival of cell lines exposed to helium and carbon ion beams. Our model is based on an observed linear correlation between radiosensitivity to ions and photons across a wide range of LET values. This linear correlation can be used to predict ion RBE, radiosensitivity, and the cell survival curve for a given LET all based on a cell’s photon survival curve.

scholarly journals Proton RBE dependence on dose in the setting of hypofractionation

2020 ◽  
Vol 93 (1107) ◽  
pp. 20190291 ◽  
Author(s):  
Thomas Friedrich
Keyword(s):  
Relative Biological Effectiveness ◽  
Review Article ◽  
Carbon Ion Therapy ◽  
Carbon Ion ◽  
Ion Therapy ◽  
Therapy Costs ◽  
Biological Effectiveness ◽  
Dose Dependent ◽  
Higher Doses ◽  
Patient Burden

Hypofractionated radiotherapy is attractive concerning patient burden and therapy costs, but many aspects play a role when it comes to assess its safety. While exploited for conventional photon therapy and carbon ion therapy, hypofractionation with protons is only rarely applied. One reason for this is uncertainty in the described dose, mainly due to the relative biological effectiveness (RBE), which is small for protons, but not negligible. RBE is generally dose-dependent, and for higher doses as used in hypofractionation, a thorough RBE evaluation is needed. This review article focuses on the RBE variability in protons and associated issues or implications for hypofractionation.

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